Associate Professor, Pediatrics, Children's Hospital, Harvard Medical School
Pediatric Nephrology
Dr. David M. Briscoe, MD
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David M. Briscoe, MD is an expert in the field of Pediatric Nephrology. He received awards:"Elected Member". David Briscoe is a published physician as well. He has 77 publications published. The latest was: Interactions between T lymphocytes and endothelial cells in allograft rejection.
Publications
- Microfluidic mazes to characterize T-cell exploration patterns following activation in vitro.
- Chronic allograft rejection: a fresh look.
- Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction.
- DEPTOR regulates vascular endothelial cell activation, proinflammatory and angiogenic responses.
- Differential activation of human T cells to allogeneic endothelial cells, epithelial cells and fibroblasts in vitro.
- VEGF-C, VEGF-A and related angiogenesis factors as biomarkers of allograft vasculopathy in cardiac transplant recipients.
- Subsets of human CD4(+) T regulatory cells express the peripheral homing receptor CXCR3.
- Cost-related immunosuppressive medication nonadherence among kidney transplant recipients.
- Effect of vascular endothelial growth factor and its receptor KDR on the transendothelial migration and local trafficking of human T cells in vitro and in vivo.
- Cutting edge: Vascular endothelial growth factor-mediated signaling in human CD45RO+ CD4+ T cells promotes Akt and ERK activation and costimulates IFN-gamma production.
- Calcineurin inhibitors activate the proto-oncogene Ras and promote protumorigenic signals in renal cancer cells.
- Calcineurin inhibitors modulate CXCR3 splice variant expression and mediate renal cancer progression.
- CD40-induced signaling in human endothelial cells results in mTORC2- and Akt-dependent expression of vascular endothelial growth factor in vitro and in vivo.
- Overexpression of vascular endothelial growth factor and the development of post-transplantation cancer.
- Every allograft needs a silver lining.
- Heme oxygenase-1 modulates the expression of the anti-angiogenic chemokine CXCL-10 in renal tubular epithelial cells.
- The effects of mTOR-Akt interactions on anti-apoptotic signaling in vascular endothelial cells.
- Organ-specific differences in the function of MCP-1 and CXCR3 during cardiac and skin allograft rejection.
- Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: relevance for the development of human breast cancer.
- Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.
- Angiogenesis and endothelial cell repair in renal disease and allograft rejection.
- Vascular endothelial growth factor-induced signaling pathways in endothelial cells that mediate overexpression of the chemokine IFN-gamma-inducible protein of 10 kDa i...
- Vascular endothelial growth factor antagonist modulates leukocyte trafficking and protects mouse livers against ischemia/reperfusion injury.
- Function of the vascular endothelial growth factor receptors Flt-1 and Flk-1/KDR in the alloimmune response in vivo.
- CD40: a mediator of pro- and anti-inflammatory signals in renal tubular epithelial cells.
- Vascular endothelial growth factor impairs the functional ability of dendritic cells through Id pathways.
- TNP-470, an angiogenesis inhibitor, attenuates the development of allograft vasculopathy.
- CD40-induced transcriptional activation of vascular endothelial growth factor involves a 68-bp region of the promoter containing a CpG island.
- The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-k...
- Proinflammatory functions of vascular endothelial growth factor in alloimmunity.
- Proangiogenic function of CD40 ligand-CD40 interactions.
- Expression patterns of vascular endothelial growth factor in human cardiac allografts: association with rejection.
- P-glycoprotein and alloimmune T-cell activation.
- Long-term care of pediatric renal transplant patients: from bench to bedside.
- A rendezvous before rejection: where do T cells meet transplant antigens?
- Microfluidic platform for the quantitative analysis of leukocyte migration signatures.
- Detection of sinus-induced orbital mycosis with standardized orbital ultrasonography: a case report.
- The use of standardized orbital ultrasound in the diagnosis of sinus induced infections of the orbit in children: a preliminary report.
- Persistently raised intraocular pressure following extracapsular cataract extraction.
- Prognosis in Guillain-Barré syndrome.
- Differential regulation of leucocyte L-selectin (CD62L) expression in normal lymphoid and inflamed extralymphoid tissues.
- Alpha 1-VIII collagen is expressed in the rat glomerulus and in resident glomerular cells.
- Consensus statement on the live organ donor.
- Risk factors for mortality in infants and young children on dialysis.
- Water channel vesicles from toad urinary bladder contain a family of proteins present in other tissues.
- P-selectin expression in myocardium of children undergoing cardiopulmonary bypass.
- Antigen-dependent activation of T helper cell subsets by endothelium.
- Role of leukocyte-endothelial cell adhesion molecules in renal inflammation: in vitro and in vivo studies.
- Challenges after pediatric transplantation.
- Outcome of renal transplantation in children less than two years of age.
- Duplex Doppler examination of renal allografts in children: correlation between renal blood flow and clinical findings.
- Immunologic targets for currently available immunosuppressive agents: what is the optimal approach for children?
- mTOR-understanding the clinical effects.
- Effects of tumor necrosis factor, lipopolysaccharide, and IL-4 on the expression of vascular cell adhesion molecule-1 in vivo. Correlation with CD3+ T cell infiltration.
- The problem of chronic rejection: influence of leukocyte-endothelial interactions.
- Pediatric renal transplantation: indications and special considerations. A position paper from the Pediatric Committee of the American Society of Transplant Physicians.
- Endothelial injury: cause and effect of alloimmune inflammation.
- Endothelial cells modify the costimulatory capacity of transmigrating leukocytes and promote CD28-mediated CD4(+) T cell alloactivation.
- Current understanding of chemokine involvement in allograft transplantation.
- Expression of the chemokine receptor CXCR3 and its ligand IP-10 during human cardiac allograft rejection.
- Interactions between T lymphocytes and endothelial cells in allograft rejection.
- Ligation of CD40 induces the expression of vascular endothelial growth factor by endothelial cells and monocytes and promotes angiogenesis in vivo.
- The allogeneic response to cultured human skin equivalent in the hu-PBL-SCID mouse model of skin rejection.
- Expression of vascular cell adhesion molecule-1 in human renal allografts.
- Predictive value of inducible endothelial cell adhesion molecule expression for acute rejection of human cardiac allografts.
- Induced expression of endothelial-leukocyte adhesion molecules in human cardiac allografts.
- Specific MDR1 P-glycoprotein blockade inhibits human alloimmune T cell activation in vitro.
- The role of the graft endothelium in transplant rejection: evidence that endothelial activation may serve as a clinical marker for the development of chronic rejection.
- The CD154-CD40 T-cell co-stimulation pathway in liver ischemia and reperfusion inflammatory responses.
- Angiogenesis in the huPBL-SCID model of human transplant rejection.
- CD40 and CD40 ligand (CD154) are coexpressed on microvessels in vivo in human cardiac allograft rejection.
- Human endothelial cell costimulation of T cell IFN-gamma production.
- Central role for CD40/CD40 ligand (CD154) interactions in transplant rejection.
- Hyporesponsiveness in pediatric recipients.
- Safety and pharmacokinetics of ascending single doses of sirolimus (Rapamune, rapamycin) in pediatric patients with stable chronic renal failure undergoing dialysis.
- Assessing the vascular effects of early erythropoietin use in pediatric renal transplant recipients.
Schools
Royal College of Surgeons In Ireland Medical School
Ea Health Bd Hosps
University Of Colorado
Chldrns Hospital
Doctors Specialties
- Pediatrics
- Pediatric Nephrology
Accepted Insurances
Awards
- Elected Member
Education
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Boston Children's Hospital
Hospital
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Boston Children's Hospital -
South Shore Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1033213699 |
| Last Name Of The Provider | BRISCOE |
| First Name Of The Provider | DAVID |
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