Physician
Radiology
Dr. David Leake, MD
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David Leake is an expert in the field of Radiology. He has 1 awards "Top MD". David Leake is a published doctor. He has 84 publications published. The most current publication "Vitamin C protects human arterial smooth muscle cells against atherogenic lipoproteins: effects of antioxidant vitamins C and E on oxidized LDL-induced adaptive increa..."
Publications
- Macrophage antioxidant protection within atherosclerotic plaques.
- A moderate reduction in extracellular pH protects macrophages against apoptosis induced by oxidized low density lipoprotein.
- A novel method for production of lipid hydroperoxide- or oxysterol-rich low-density lipoprotein.
- Mechanism of the antioxidant to pro-oxidant switch in the behavior of dehydroascorbate during LDL oxidation by copper(II) ions.
- In vitro antioxidant activity of coffee compounds and their metabolites.
- Aqueous peroxyl radical exposure to THP-1 cells causes glutathione loss followed by protein oxidation and cell death without increased caspase-3 activity.
- Common variants of apolipoprotein A-IV differ in their ability to inhibit low density lipoprotein oxidation.
- Low density lipoprotein undergoes oxidation within lysosomes in cells.
- Ascorbate does not protect macrophages against apoptosis induced by oxidised low density lipoprotein.
- Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men.
- Saturated fat-induced changes in Sf 60-400 particle composition reduces uptake of LDL by HepG2 cells.
- Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2.
- Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal.
- Oxidation affects the flow-induced aggregation of low density lipoprotein and its inhibition by albumin.
- Mechanisms by which cysteine can inhibit or promote the oxidation of low density lipoprotein by copper.
- Degree of oxidation of low density lipoprotein affects expression of CD36 and PPARgamma, but not cytokine production, by human monocyte-macrophages.
- Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL: important role of uric acid.
- Effects of oxidised low density lipoprotein on dendritic cells: a possible immunoregulatory component of the atherogenic micro-environment?
- Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses.
- Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages.
- Measurement of copper-binding sites on low density lipoprotein.
- Flavonoids and the oxidation of low-density lipoprotein.
- Evidence for oxidised low density lipoprotein in synovial fluid from rheumatoid arthritis patients.
- Vitamin C protects human vascular smooth muscle cells against apoptosis induced by moderately oxidized LDL containing high levels of lipid hydroperoxides.
- Induction of antioxidant stress proteins in vascular endothelial and smooth muscle cells: protective action of vitamin C against atherogenic lipoproteins.
- Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: ...
- Quantitative immunohistochemical detection of oxidized low density lipoprotein in the rabbit arterial wall.
- Vitamin C protects human arterial smooth muscle cells against atherogenic lipoproteins: effects of antioxidant vitamins C and E on oxidized LDL-induced adaptive increa...
- Human serum, cysteine and histidine inhibit the oxidation of low density lipoprotein less at acidic pH.
- Non-oxidative modification of low density lipoprotein by ruptured myocytes.
- The effects of pH on the oxidation of low-density lipoprotein by copper and metmyoglobin are different.
- Does an acidic pH explain why low density lipoprotein is oxidised in atherosclerotic lesions?
- Modulation of vascular tone by low density lipoproteins: effects on L-arginine transport and nitric oxide synthesis.
- The effects of ascorbate and dehydroascorbate on the oxidation of low-density lipoprotein.
- Practical approaches to low density lipoprotein oxidation: whys, wherefores and pitfalls.
- Non-oxidative modification of native low-density lipoprotein by oxidized low-density lipoprotein.
- High-resolution mapping of the frequency of lipid deposits in thoracic aortae from cholesterol-fed and heritable hyperlipidaemic rabbits.
- Oxidation of low density lipoprotein by iron or copper at acidic pH.
- Transition metal ions within human atherosclerotic lesions can catalyse the oxidation of low density lipoprotein by macrophages.
- Induction of the antioxidant stress proteins heme oxygenase-1 and MSP23 by stress agents and oxidised LDL in cultured vascular smooth muscle cells.
- Oxidisability of low density lipoproteins in patients with carotid or femoral artery atherosclerosis.
- The effects of free radical scavengers on the oxidation of low-density lipoproteins by macrophages.
- Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper.
- Iron released from transferrin at acidic pH can catalyse the oxidation of low density lipoprotein.
- NADPH oxidase is not essential for low density lipoprotein oxidation by human monocyte-derived macrophages.
- The oxidation of low density lipoprotein by cells or iron is inhibited by zinc.
- Ascorbic acid can either increase or decrease low density lipoprotein modification.
- The effect of inhibitors of free radical generating-enzymes on low-density lipoprotein oxidation by macrophages.
- Acidic pH enables caeruloplasmin to catalyse the modification of low-density lipoprotein.
- Acidic pH increases the oxidation of LDL by macrophages.
- Oxidation of low density lipoprotein by bovine and porcine aortic endothelial cells and porcine endocardial cells in culture.
- Hydroxypyridinones and desferrioxamine inhibit macrophage-mediated LDL oxidation by iron but not by copper.
- Oxidised low density lipoproteins and atherogenesis.
- CD4-positive T-lymphocytes can oxidatively modify low density lipoprotein.
- The modification of low density lipoprotein by the flavonoids myricetin and gossypetin.
- Oxidised low density lipoproteins convert oxyhaemoglobin from ruptured erythrocytes to reactive ferryl forms.
- The interaction between ruptured erythrocytes and low-density lipoproteins.
- The effect of EDTA on the oxidation of low density lipoprotein.
- The oxidative modification of low density lipoprotein by human lymphocytes.
- Free radicals and low-density lipoprotein oxidation by macrophages.
- Modification of low-density lipoproteins by flavonoids.
- The oxidative modification of low-density lipoproteins by macrophages.
- Failure of platelet-derived growth factor plus insulin to stimulate sustained proliferation of Swiss 3T3 cells. Requirement for hydrocortisone, prostaglandin E1, lipop...
- Macrophage proteases can modify low density lipoproteins to increase their uptake by macrophages.
- Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages.
- Alpha-tocopherol consumption during low-density-lipoprotein oxidation.
- The role of oxidative modification and antioxidants in LDL metabolism and atherosclerosis.
- The effect of macrophage stimulation on the uptake of acetylated low-density lipoproteins.
- Macrophages possess both neutral and acidic protease activities toward low density lipoproteins.
- The effects of acetylated low-density lipoproteins on fluid-phase pinocytosis by macrophages.
- The modification of low density lipoproteins by macrophages by oxidation or proteolysis.
- Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.
- Properties and subcellular localization of elastase-like activities of arterial smooth muscle cells in culture.
- Properties and subcellular localization of adenosine diphosphatase in arterial smooth muscle cells in culture.
- Subcellular fractionation of arterial smooth muscle cells laden with lipid following incubation with low density lipoproteins and chloroquine.
- Properties and subcellular localization of acid phosphatase activity in cultured arterial smooth muscle cells.
- Lipid accumulation in arterial smooth muscle cells in culture. Morphological and biochemical changes caused by low density lipoproteins and chloroquine.
- Subcellular localization of adenosine diphosphatase in cultured pig arterial endothelial cells.
- Modification of the rate of pinocytosis in arterial smooth muscle cells in culture.
- Quantitative studies of pinocytosis by arterial endothelial and smooth muscle cells in culture.
- Proteolytic degradation of low density lipoproteins by arterial smooth muscle cells: the role of individual cathepsins.
- Quantitative studies of pinocytic uptake of 125I-labelled polyvinylpyrrolidone by pig aortic smooth-muscle cells in culture.
- A method to measure the pinocytic uptake of 125I-labelled polyvinylpyrrolidone by pig aortic smooth muscle and endothelial cells in culture.
Schools
University Of Texas Medical Branch At Galveston
University of South Florida College of Medicine
University of Texas At Houston Medical School At Houston
Baylor College Of Medicine amp Affiliated Hospitals
Doctors Specialties
- Neuroradiology
- Radiology
Accepted Insurances
Awards
- Top MD
Education
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University of Texas Health Science Center -
University of South Florida -
University of Texas Medical Branch
Hospital
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Seton Medical Center Austin
Drug Facts
| NPI NUMBER | 1093719825 | |
| NPPES Provider LastName | LEAKE | |
| NPPES Provider FirstName | DAVID | |
| NPPES Provider ZIPCode | 787595873 | |
| NPPES Provider State | TX | |
| Specialty Description | Diagnostic Radiology | |
| Total Claim Count | 15.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1093719825 |
| Last Name Of The Provider | LEAKE |
| First Name Of The Provider | DAVID |
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