Infectious Diseases Consultations, Ben Taub General Hospital
Infectious Disease
Dr. David J. Tweardy, MD
David Tweardy practices Infectious Disease. He graduated from Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School has a rank of 1 in research and a 12 in primary care He received awards:"Whos Who in America", "Who's Who in Medicine and Healthcare", "Who's Who in Science and Engineering", "Best Doctors in America", "A. L. Bortree lecturer", "Physician Scientist Award", "Aesculapian Club", "Sigma Xi", "Research Apprenticeship Award" and "Whos Who in Medicine and Healthcare". Doctor David J. Tweardy, MD has written publications. He has 100 publications published with PubMed. The lastest publication is: 'Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils.'
Publications
- Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO.
- Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer.
- Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity.
- STAT3 Signaling Is Activated Preferentially in Tumor-Initiating Cells in Claudin-Low Models of Human Breast Cancer.
- Chaperonin-containing TCP-1 complex directly binds to the cytoplasmic domain of the LOX-1 receptor.
- Modulation of STAT3 folding and function by TRiC/CCT chaperonin.
- Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer.
- RESTORATION OF LUNG SURFACTANT PROTEIN D BY IL-6 PROTECTS AGAINST SECONDARY PNEUMONIA FOLLOWING HEMORRHAGIC SHOCK.
- Stat3 Activation Links a C/EBPδ to Myostatin Pathway to Stimulate Loss of Muscle Mass.
- Modulation of the unfolded protein response during hepatocyte and cardiomyocyte apoptosis in trauma/hemorrhagic shock.
- Intrinsic molecular characteristics of inhibiting STAT3 activation and dimerization through targeting the phosphotyrosine binding site within the SH2 domain-A molecula...
- FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report.
- Increased apoptosis of peripheral blood neutrophils is associated with reduced incidence of infection in trauma patients with hemorrhagic shock.
- Selective small molecule stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model.
- Nanoscale surface modification favors benign biofilm formation and impedes adherence by pathogens.
- Severe Pulmonary Involvement in a Case Attributed to Domestically Acquired Seoul Hantavirus in the United States.
- Lethal human neutropenic entercolitis caused by Clostridium chauvoei in the United States: Tip of the iceberg?
- Intracranial tuberculomas in adults: A report of twelve consecutive patients in Houston, Texas.
- Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and apoptosis induction by a novel small molecule Stat3 inhibitor.
- IL-6-Mediated Activation of Stat3? Prevents Trauma/Hemorrhagic Shock-Induced Liver Inflammation.
- Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}.
- Substance P signaling contributes to granuloma formation in Taenia crassiceps infection, a murine model of cysticercosis.
- "Personalizing" academic medicine: opportunities and challenges in implementing genomic profiling.
- Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3.
- Chemical probes that competitively and selectively inhibit Stat3 activation.
- SH2 domain binding to phosphopeptide ligands: potential for drug targeting.
- Substance P is required for the pathogenesis of EMCV infection in mice.
- Increased expression of type-1 fimbriae by nonpathogenic Escherichia coli 83972 results in an increased capacity for catheter adherence and bacterial interference.
- T40214/PEI complex: a potent therapeutics for prostate cancer that targets STAT3 signaling.
- Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3.
- Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha.
- Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end.
- Conditional overexpression of Stat3alpha in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene ...
- Aberrant chromatin remodeling by retinoic acid receptor alpha fusion proteins assessed at the single-cell level.
- Substance P is responsible for physiological alterations such as increased chloride ion secretion and glucose malabsorption in cryptosporidiosis.
- Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock.
- Interleukin-6 treatment reverses apoptosis and blunts susceptibility to intraperitoneal bacterial challenge following hemorrhagic shock.
- Unique structural determinants for Stat3 recruitment and activation by the granulocyte colony-stimulating factor receptor at phosphotyrosine ligands 704 and 744.
- Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer.
- Enhancing or eliminating signals for cell survival to treat disease.
- Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.
- Induction of IL-6 within the rodent intestinal muscularis after intestinal surgical stress.
- Functional significance of inflammatory mediators in a murine model of resuscitated hemorrhagic shock.
- G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through i...
- Increased susceptibility to liver injury after hemorrhagic shock in rats chronically fed ethanol: role of nuclear factor-kappa B, interleukin-6, and granulocyte colony...
- Reduced intranuclear mobility of APL fusion proteins accompanies their mislocalization and results in sequestration and decreased mobility of retinoid X receptor alpha.
- Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif.
- Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock.
- Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells.
- Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.
- Amplification of the proinflammatory transcription factor cascade increases with severity of uncontrolled hemorrhage in swine.
- The effect of recombinant factor VIIa on noncoagulopathic pigs with grade V liver injuries.
- Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy.
- Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways.
- A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock.
- Molecular cloning and characterization of a cDNA for human granulocyte colony-stimulating factor (G-CSF) from a glioblastoma multiforme cell line and localization of t...
- Human granulocyte colony-stimulating factor (G-CSF), the premier granulopoietin: biology, clinical utility, and receptor structure and function.
- Modulation of human G-CSF receptor mRNA and protein in normal and leukemic myeloid cells by G-CSF and retinoic acid.
- Function of hematopoietin receptor subunits in hepatic cells and fibroblasts.
- Cytokine induction of interferon regulatory factor-1 in hepatocytes.
- A dual mechanism of immunosuppression by FK-506. Differential suppression of IL-4 and IL-10 levels in T helper 2 cells.
- HLA and ethnic associations among systemic sclerosis patients with anticentromere antibodies.
- Severe systemic sclerosis with anti-topoisomerase I antibodies is associated with an HLA-DRw11 allele.
- Molecular cloning, characterization, and tissue distribution of rat lipopolysaccharide binding protein. Evidence for extrahepatic expression.
- Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases.
- Granulocyte colony-stimulating factor receptor mRNA upregulation is an immediate early marker of myeloid differentiation and exhibits dysfunctional regulation in leuke...
- Lectin-induced apoptosis of tumour cells.
- Granulocyte-macrophage colony-stimulating factor augmentation of T-cell receptor-dependent and T-cell receptor-independent thymocyte proliferation.
- Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer.
- TGF-alpha and EGFR in head and neck cancer.
- Induction of hepatocyte lipopolysaccharide binding protein in models of sepsis and the acute-phase response.
- Effect of granulocyte-macrophage colony-stimulating factor on lymphokine-activated killer cell induction.
- Granulocyte colony-stimulating factor rapidly activates a distinct STAT-like protein in normal myeloid cells.
- Retinoic acid normalizes the increased gene transcription rate of TGF-alpha and EGFR in head and neck cancer cell lines.
- Augmentation of TNF cytotoxicity by protein kinase C inhibitors: role of arachidonic acid and manganese superoxide dismutase.
- Making sense of the combined effect of interleukin-2 and interleukin-4 on lymphocytes using a mathematical model.
- Quantitative immunohistochemical analysis of transforming growth factor-alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head...
- Granulocyte colony-stimulating factor activation of Stat3 alpha and Stat3 beta in immature normal and leukemic human myeloid cells.
- Granulocyte colony-stimulating factor (G-CSF) production in hemorrhagic shock requires both the ischemic and resuscitation phase.
- TCR-gamma genes are rearranged but not transcribed in IL-7R alpha-deficient mice.
- Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epitheli...
- Hemorrhagic shock induces G-CSF expression in bronchial epithelium.
- Somatostatin negatively regulates parasite burden and granulomatous responses in cysticercosis.
- G-CSF instillation into rat lungs mediates neutrophil recruitment, pulmonary edema, and hypoxia.
- Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock.
- Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithe...
- Asynchronous modulation of transforming growth factor alpha and epidermal growth factor receptor protein expression in progression of premalignant lesions to head and ...
- Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival.
- IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections.
- Increased expression of the differentiation-defective granulocyte colony-stimulating factor receptor mRNA isoform in acute myelogenous leukemia.
- Normalization of EGFR mRNA levels following restoration of wild-type p53 in a head and neck squamous cell carcinoma cell line.
- Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter.
- Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer.
- Activation of STAT proteins in the lung of rats following resuscitation from hemorrhagic shock.
- Stat3 and G-CSF-induced myeloid differentiation.
- Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury.
- Activation of STAT proteins following ischemia reperfusion injury demonstrates a distinct IL-6 and G-CSF mediated profile.
- Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.
- Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils.
Schools
Harvard Medical School
Case Western Res University Clevelan
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Awards
- Who’s Who in America
- Who's Who in Medicine and Healthcare
- Who's Who in Science and Engineering
- Best Doctors in America
- A. L. Bortree lecturer
- Physician Scientist Award
- Aesculapian Club
- Sigma Xi
- Research Apprenticeship Award
- Whos Who in Medicine and Healthcare
Education
-
Case Western Reserve University - University Hospitals -
Harvard Medical School
Hospital
-
Texas Children's Hospital
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