Professor and Chief of Pediatric Surgery, Johns Hopkins University Pediatric Surgeon in Chief, Johns Hopkins Hospital Co-Director, Johns Hopkins Childrens Center
General Surgery
Dr. David J. Hackam, MD
Doctor David J. Hackam, MD works in the field of General Surgery. He has 4 awards "Member", "President", "Elected Member" and "Fellow (FACS)". David Hackam is a published doctor and has 100 publications published. The lastest was: 'Bioavailability of oral ciprofloxacin in early postsurgical patients.'
Publications
- Generation of an artificial intestine for the management of short bowel syndrome.
- Evidence-based feeding strategies before and after the development of necrotizing enterocolitis.
- A novel scoring system to predict the development of necrotizing enterocolitis totalis in premature infants.
- Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges.
- Synthetic small intestinal scaffolds for improved studies of intestinal differentiation.
- Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch.
- Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling.
- A Critical Role for TLR4 Induction of Autophagy in the Regulation of Enterocyte Migration and the Pathogenesis of Necrotizing Enterocolitis.
- Lipopolysaccharide Clearance, Bacterial Clearance, and Systemic Inflammatory Responses Are Regulated by Cell Type-Specific Functions of TLR4 during Sepsis.
- Cellular specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury.
- Modeling the interactions of bacteria and Toll-like receptor-mediated inflammation in necrotizing enterocolitis.
- Using a continuum model to predict closure time of gaps in intestinal epithelial cell layers.
- Intestinal Epithelial Toll-like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice.
- WNT1 Inducible Signaling Pathway Protein 1 (WISP1) Contributes to Ventilator-Induced Lung Injury.
- Guts, germs and glucose: understanding the effects of prematurity on the interaction between bacteria and nutrient absorption across the intestine.
- Cloacal exstrophy variant with intravesical phallus: Further description of anatomy and implications for gender reassignment.
- The role of innate immune-stimulated epithelial apoptosis during gastrointestinal inflammatory diseases.
- Danger at the doorstep: Regulation of bacterial translocation across the intestinal barrier by nitric oxide.
- Worms, flies and four-legged friends: the applicability of biological models to the understanding of intestinal inflammatory diseases.
- DNA attenuates enterocyte Toll-like receptor 4-mediated intestinal mucosal injury after remote trauma.
- Intestinal stem cells and their roles during mucosal injury and repair.
- New insights into the pathogenesis and treatment of necrotizing enterocolitis: Toll-like receptors and beyond.
- Continuum model of collective cell migration in wound healing and colony expansion.
- Systemic inflammation and liver injury following hemorrhagic shock and peripheral tissue trauma involve functional TLR9 signaling on bone marrow-derived cells and pare...
- Embryonic mouse blood flow and oxygen correlate with early pancreatic differentiation.
- Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium.
- Endorectal pull-through for Hirschsprung's disease-a multicenter, long-term comparison of results: transanal vs transabdominal approach.
- Extracellular high mobility group box-1 (HMGB1) inhibits enterocyte migration via activation of Toll-like receptor-4 and increased cell-matrix adhesiveness.
- Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis.
- Presence of pneumomediastinum after blunt trauma in children: what does it really mean?
- Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis.
- A role for connexin43 in macrophage phagocytosis and host survival after bacterial peritoneal infection.
- No longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammation.
- Interferon-gamma inhibits enterocyte migration by reversibly displacing connexin43 from lipid rafts.
- Migrating cells retain gap junction plaque structure and function.
- Hypertrophic pyloric stenosis in newborns younger than 21 days: remodeling the path of surgical intervention.
- Increased expression and internalization of the endotoxin coreceptor CD14 in enterocytes occur as an early event in the development of experimental necrotizing enteroc...
- Comparative analysis of chest tube thoracostomy and video-assisted thoracoscopic surgery in empyema and parapneumonic effusion associated with pneumonia in children.
- The role of epithelial Toll-like receptor signaling in the pathogenesis of intestinal inflammation.
- Activated macrophages inhibit enterocyte gap junctions via the release of nitric oxide.
- One-dimensional elastic continuum model of enterocyte layer migration.
- Hypoxia causes an increase in phagocytosis by macrophages in a HIF-1alpha-dependent manner.
- Systemic inflammation and remote organ injury following trauma require HMGB1.
- A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair.
- Toll-like receptor 4 plays a role in macrophage phagocytosis during peritoneal sepsis.
- Interferon-gamma inhibits intestinal restitution by preventing gap junction communication between enterocytes.
- Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling.
- Nitric oxide inhibits enterocyte migration through activation of RhoA-GTPase in a SHP-2-dependent manner.
- The role of the intestinal barrier in the pathogenesis of necrotizing enterocolitis.
- The Ex Utero Intrapartum Treatment (EXIT) procedure: new challenges.
- Laparotomy versus peritoneal drainage for necrotizing enterocolitis and perforation.
- An analysis of proctoscopy vs computed tomography scanning in the diagnosis of rectal injuries in children: which is better?
- Laparoscopic appendectomy in children with perforated Appendicitis.
- Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier.
- Lipopolysaccharide induces cyclooxygenase-2 in intestinal epithelium via a noncanonical p38 MAPK pathway.
- The role of gap junctions in health and disease.
- Laparoscopic splenectomy in children.
- An approach to the writing of a scientific manuscript.
- Increased expression and function of integrins in enterocytes by endotoxin impairs epithelial restitution.
- Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis.
- The timing of delivery of infants with gastroschisis influences outcome.
- Primary vs delayed surgery for spontaneous pneumothorax in children: which is better?
- The role of the glutathione antioxidant system in gut barrier failure in a rodent model of experimental necrotizing enterocolitis.
- Endotoxin differentially modulates the basolateral and apical sodium/proton exchangers (NHE) in enterocytes.
- Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions.
- Factors influencing survival in newborns with congenital diaphragmatic hernia: the relative role of timing of surgery.
- How low can you go? Effectiveness and safety of extracorporeal membrane oxygenation in low-birth-weight neonates.
- Mechanisms of pediatric trauma deaths in Canada and the United States: the role of firearms.
- Effect of age on cervical spine injuries in children after motor vehicle collisions: effectiveness of restraint devices.
- The influence of Down's syndrome on the management and outcome of children with Hirschsprung's disease.
- Utility of radiographic hepatic injury grade in predicting outcome for children after blunt abdominal trauma.
- Cellular, biochemical, and clinical aspects of wound healing.
- The development of animal models for the study of necrotizing enterocolitis.
- Mesenteric inflammatory pseudotumor as a cause of abdominal pain in a teenager: presentation and literature review.
- An unusual cause of rectal bleeding and intestinal obstruction in a child with peripheral vascular malformations.
- Snow-related recreational injuries in children: assessment of morbidity and management strategies.
- The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes.
- Functional expression of Nramp1 in vitro in the murine macrophage line RAW264.7.
- Role of COPI in phagosome maturation.
- Effects of other intra-abdominal injuries on the diagnosis, management, and outcome of small bowel trauma.
- Indirect role for COPI in the completion of FCgamma receptor-mediated phagocytosis.
- Stoma closure and wound infection: an evaluation of risk factors.
- Wound infection during stoma closure.
- Interleukin-1 increases vacuolar-type H+-ATPase activity in murine peritoneal macrophages.
- Characterization and subcellular localization of target membrane soluble NSF attachment protein receptors (t-SNAREs) in macrophages. Syntaxins 2, 3, and 4 are present ...
- Laparoscopic management of intussusception caused by colonic lipomata: a case report and review of the literature.
- Intracellular pH regulation in leukocytes: mechanisms and functional significance.
- Exudative neutrophils show impaired pH regulation compared with circulating neutrophils.
- Enteric duplication in the adult, derived from the foregut, midgut and hindgut: presentation, patterns and literature review.
- Single-stage repair of Hirschsprung's disease: a comparison of 109 patients over 5 years.
- Rho is required for the initiation of calcium signaling and phagocytosis by Fcgamma receptors in macrophages.
- Mechanism of decreased in vitro murine macrophage cytokine release after exposure to carbon dioxide: relevance to laparoscopic surgery.
- Regulation of phagosomal acidification. Differential targeting of Na+/H+ exchangers, Na+/K+-ATPases, and vacuolar-type H+-atpases.
- Host response to laparoscopic surgery: mechanisms and clinical correlates.
- Enterocolitis after the surgical treatment of Hirschsprung's disease: risk factors and financial impact.
- Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification.
- v-SNARE-dependent secretion is required for phagocytosis.
- Bioavailability of oral ciprofloxacin in early postsurgical patients.
- Diagnosis and outcome of Hirschsprung''s disease: does age really matter?
Conditions Treated
- Appendicitis
Doctors Specialties
- Pediatric Surgery
- General Surgery
Accepted Insurances
Awards
- Member
- President
- Elected Member
- Fellow (FACS)
Education
-
University of Western Ontario
Hospital
-
Johns Hopkins Hospital
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