Associate Professor, Medicine, Case Western Reserve University School of Medicine
Infectious Disease
Dr. David H. Canaday, MD
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David Canaday is an expert in the field of Infectious Disease. He researched medicine at Washington University School of Medicine in St. Louis. David Canaday is a published doctor. He has 48 papers published. The most current publication "Activation of human CD8+ alpha beta TCR+ cells by Mycobacterium tuberculosis via an alternate class I MHC antigen-processing pathway."
Publications
- Productive HIV-1 infection is enriched in CD4(-)CD8(-) double negative (DN) T cells at pleural sites of dual infection with HIV and Mycobacterium tuberculosis.
- Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults.
- Production of CD4(+) and CD8 (+) T Cell Hybridomas.
- Characterization of MHC-II antigen presentation by B cells and monocytes from older individuals.
- Decline of influenza-specific CD8+ T cell repertoire in healthy geriatric donors.
- T cell hybridomas to study MHC-II restricted B-cell receptor-mediated antigen presentation by human B cells.
- Activation of P-TEFb at Sites of Dual HIV/TB Infection, and Inhibition of MTB-Induced HIV Transcriptional Activation by the Inhibitor of CDK9, Indirubin-3'-Monoxime.
- Mycobacterium tuberculosis promotes HIV trans-infection and suppresses major histocompatibility complex class II antigen processing by dendritic cells.
- Mycobacterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and class I MHC antigen cross processing by TLR9.
- Preserved MHC class II antigen processing in monocytes from HIV-infected individuals.
- Human gamma delta T cells: a lymphoid lineage cell capable of professional phagocytosis.
- Parameters underlying distinct T cell-dependent polysaccharide-specific IgG responses to an intact gram-positive bacterium versus a soluble conjugate vaccine.
- Endothelial progenitor cells possess monocyte-like antigen-presenting and T-cell-co-stimulatory capacity.
- Induction of HIV type 1 expression correlates with T cell responsiveness to mycobacteria in patients coinfected with HIV type 1 and Mycobacterium tuberculosis.
- Macrophages pulsed with Streptococcus pneumoniae elicit a T cell-dependent antibody response upon transfer into naive mice.
- Rapid MHC-II antigen presentation of HIV type 1 by human dendritic cells.
- CpG-induced IFNgamma expands TLR4-specific IL-18 responses in vivo.
- Class II MHC antigen presentation defect in neonatal monocytes is not correlated with decreased MHC-II expression.
- Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC function.
- Role of phagosomes and major histocompatibility complex class II (MHC-II) compartment in MHC-II antigen processing of Mycobacterium tuberculosis in human macrophages.
- Mouse endothelial cells cross-present lymphocyte-derived antigen on class I MHC via a TAP1- and proteasome-dependent pathway.
- Mycobacterium tuberculosis heat shock fusion protein enhances class I MHC cross-processing and -presentation by B lymphocytes.
- The purinergic P2X7 receptor is not required for control of pulmonary Mycobacterium tuberculosis infection.
- Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens.
- Prolonged toll-like receptor signaling by Mycobacterium tuberculosis and its 19-kilodalton lipoprotein inhibits gamma interferon-induced regulation of selected genes i...
- Bacterial heat shock proteins enhance class II MHC antigen processing and presentation of chaperoned peptides to CD4+ T cells.
- Bacterial heat shock proteins promote CD91-dependent class I MHC cross-presentation of chaperoned peptide to CD8+ T cells by cytosolic mechanisms in dendritic cells ve...
- The Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits gamma interferon-regulated HLA-DR and Fc gamma R1 on human macrophages through Toll-like receptor 2.
- Antigen processing of the heptavalent pneumococcal conjugate vaccine carrier protein CRM(197) differs depending on the serotype of the attached polysaccharide.
- ATP and control of intracellular growth of mycobacteria by T cells.
- Identification by mass spectrometry of CD8(+)-T-cell Mycobacterium tuberculosis epitopes within the Rv0341 gene product.
- Age-related differences in polyfunctional T cell responses.
- Older Age Is Associated with Peripheral Blood Expansion of Naïve B Cells in HIV-Infected Subjects on Antiretroviral Therapy.
- Mycobacterial Phosphatidylinositol Mannoside 6 (PIM6) Up-Regulates TCR-Triggered HIV-1 Replication in CD4(+) T Cells.
- Membrane permeability changes in gamma-irradiated muscle cells.
- Choosing and preparing antigen-presenting cells.
- Influenza-induced production of interferon-alpha is defective in geriatric individuals.
- Human immunity to M. tuberculosis: T cell subsets and antigen processing.
- T-cell hybridomas from HLA-transgenic mice as tools for analysis of human antigen processing.
- CD4(+) and CD8(+) T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas/Fas ligand-independent mechanism.
- Human natural killer cells mediate killing of intracellular Mycobacterium tuberculosis H37Rv via granule-independent mechanisms.
- Phagocytic antigen processing and effects of microbial products on antigen processing and T-cell responses.
- Activation of human CD8+ alpha beta TCR+ cells by Mycobacterium tuberculosis via an alternate class I MHC antigen-processing pathway.
- Flow analysis of MHC molecules and other membrane proteins in isolated phagosomes.
- Human alveolar T lymphocyte responses to Mycobacterium tuberculosis antigens: role for CD4+ and CD8+ cytotoxic T cells and relative resistance of alveolar macrophages ...
- Preserved MHC-II antigen processing and presentation function in chronic HCV infection.
- Polyfunctional Mycobacterium tuberculosis-specific effector memory CD4+ T cells at sites of pleural TB.
Schools
Washington Center School of Medicine
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
- GEHA
- Medicare MCR
- Tricare
Education
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Case Western Reserve University - University Hospitals -
University of Minnesota -
Washington University School of Medicine in St. Louis
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