Physician

Obstetrics & Gynecology

David Clarke practices Obstetrics & Gynecology. He attended Wayne State University School of Medicine. Wayne State University School of Medicine is ranked 63/85 in Research/PrimaryCare. He has 1 awards "Fellow (FACOG)". Dr. David E. Clarke, PHD is also a published doctor. He has 83 publication published. The most recent publication is: Increased sensitivity of E. coli to novobiocin, EDTA and the anticalmodulin drug W7 following overproduction of DjlA requires a functional transmembrane domain.

Publications

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• Exotic non-abelian anyons from conventional fractional quantum Hall states.
• HdfR is a regulator in Photorhabdus luminescens that modulates metabolism and symbiosis with the nematode Heterorhabditis.
• An affinity purification procedure to isolate oxidized p53.
• Mapping a Noncovalent Protein-Peptide Interface by Top-Down FTICR Mass Spectrometry Using Electron Capture Dissociation.
• Complete genome sequence of the Crohn's disease-associated adherent-invasive Escherichia coli strain HM605.
• Effects on quality of life, anti-cancer responses, breast conserving surgery and survival with neoadjuvant docetaxel: a randomised study of sequential weekly versus th...
• Degradation of the extracellular matrix components by bacterial-derived metalloproteases: Implications for inflammatory bowel diseases.
• Identification of Two Reactive Cysteine Residues in the Tumor Suppressor Protein p53 Using Top-Down FTICR Mass Spectrometry.
• The development of evidence based guidelines for clinical practice portfolios.
• Pilot testing of guidelines to support good practice in the development of professional portfolios.
• The Regulation of Secondary Metabolism and Mutualism in the Insect Pathogenic Bacterium Photorhabdus luminescens.
• Dissecting the immune response to the entomopathogen Photorhabdus.
• Probing the tri-trophic interaction between insects, nematodes and Photorhabdus.
• A metabolic switch is involved in lifestyle decisions in Photorhabdus luminescens.
• Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation.
• The serine palmitoyltransferase from Sphingomonas wittichii RW1: An interesting link to an unusual acyl carrier protein.
• The Rcs phosphorelay: more than just a two-component pathway.
• The role of iron uptake in pathogenicity and symbiosis in Photorhabdus luminescens TT01.
• Implementing arbitrary phase gates with Ising anyons.
• Binding a heparin derived disaccharide to defensin inspired peptides: insights to antimicrobial inhibition from gas-phase measurements.
• Online quench-flow electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry for elucidating kinetic and chemical enzymatic reaction mechanisms.
• Conformational preferences of linear beta-defensins are revealed by ion mobility-mass spectrometry.
• Subdivision of the bacterioferritin comigratory protein family of bacterial peroxiredoxins based on catalytic activity.
• Identification of genes involved in the mutualistic colonization of the nematode Heterorhabditis bacteriophora by the bacterium Photorhabdus luminescens.
• Elevated levels of sigma S inhibit biofilm formation in Escherichia coli: a role for the Rcs phosphorelay.
• Dissection of the DNA mimicry of the bacteriophage T7 Ocr protein using chemical modification.
• Dying and necrotic neutrophils are anti-inflammatory secondary to the release of alpha-defensins.
• Efficient production of human beta-defensin 2 (HBD2) in Escherichia coli.
• Preparation of isotopically labelled recombinant beta-defensin for NMR studies.
• Interrogating the molecular details of the peroxiredoxin activity of the Escherichia coli bacterioferritin comigratory protein using high-resolution mass spectrometry.
• Comparative functional analysis of the RcsC sensor kinase from different Enterobacteriaceae.
• Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity.
• Photorhabdus: a model for the analysis of pathogenicity and mutualism.
• Motility is required for the competitive fitness of entomopathogenic Photorhabdus luminescens during insect infection.
• Plant host and sugar alcohol induced exopolysaccharide biosynthesis in the Burkholderia cepacia complex.
• The importance of the Rcs phosphorelay in the survival and pathogenesis of the enteropathogenic yersiniae.
• Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3.
• Bacterial biosynthesis of a multipotent stilbene.
• A type II polyketide synthase is responsible for anthraquinone biosynthesis in Photorhabdus luminescens.
• Maturation of McjA precursor peptide into active microcin MccJ25.
• Covalent dimer species of beta-defensin Defr1 display potent antimicrobial activity against multidrug-resistant bacterial pathogens.
• Mutualism and pathogenesis in Xenorhabdus and Photorhabdus: two roads to the same destination.
• The yjbEFGH locus in Escherichia coli K-12 is an operon encoding proteins involved in exopolysaccharide production.
• An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition.
• Nematode symbiont for Photorhabdus asymbiotica.
• The role of the Rcs phosphorelay in Enterobacteriaceae.
• Structural and functional studies of defensin-inspired peptides.
• The regulation of pathogenicity and mutualism in Photorhabdus.
• The gene stlA encodes a phenylalanine ammonia-lyase that is involved in the production of a stilbene antibiotic in Photorhabdus luminescens TT01.
• The exbD gene of Photorhabdus temperata is required for full virulence in insects and symbiosis with the nematode Heterorhabditis.
• The pbgPE operon in Photorhabdus luminescens is required for pathogenicity and symbiosis.
• Structure-activity Relationships in defensin dimers: a novel link between beta-defensin tertiary structure and antimicrobial activity.
• Cloning, expression, purification, crystallization and preliminary X-ray characterization of the full-length single-stranded DNA-binding protein from the hyperthermoph...
• Study of the attachment of Pseudomonas aeruginosa on gold and modified gold surfaces using surface plasmon resonance.
• The RcsC sensor kinase is required for normal biofilm formation in Escherichia coli K-12 and controls the expression of a regulon in response to growth on a solid surf...
• The transmembrane domain of the DnaJ-like protein DjlA is a dimerisation domain.
• Biotinylation in the hyperthermophile Aquifex aeolicus.
• A hexA homologue from Photorhabdus regulates pathogenicity, symbiosis and phenotypic variation.
• The ner gene of Photorhabdus: effects on primary-form-specific phenotypes and outer membrane protein composition.
• Diagnostic efficiency of the Hospital Anxiety and Depression Scale in women with early stage breast cancer.
• Genetic analysis of the RcsC sensor kinase from Escherichia coli K-12.
• Effects of antioxidant pretreatment on the survival of embryonic dopaminergic neurons in vitro and following grafting in an animal model of Parkinson's disease.
• UBA domains mediate protein-protein interactions between two DNA damage-inducible proteins.
• UBA domains of DNA damage-inducible proteins interact with ubiquitin.
• Dosage suppressors of pds1 implicate ubiquitin-associated domains in checkpoint control.
• Philosophy: a key to open the door to critical thinking.
• Apoptosis in primary cultures of E14 rat ventral mesencephala: time course of dopaminergic cell death and implications for neural transplantation.
• Increased sensitivity of E. coli to novobiocin, EDTA and the anticalmodulin drug W7 following overproduction of DjlA requires a functional transmembrane domain.
• Process recording: of what value is examining nursing interaction through assignment work?
• Creation of monosomic derivatives of human cultured cell lines.
• Point mutations in the transmembrane domain of DjlA, a membrane-linked DnaJ-like protein, abolish its function in promoting colanic acid production via the Rcs signal ...
• A novel DnaJ-like protein in Escherichia coli inserts into the cytoplasmic membrane with a type III topology.
• Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols.
• Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13.
• The gene coding for polynucleotide phosphorylase in Photorhabdus sp. strain K122 is induced at low temperatures.
• Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler-Najjar syndrome type 2.
• Cosegregation of intragenic markers with a novel mutation that causes Crigler-Najjar syndrome type I: implication in carrier detection and prenatal diagnosis.
• Differential expression and induction of UDP-glucuronosyltransferase isoforms in hepatic and extrahepatic tIssues of a fish, Pleuronectes platessa: immunochemical and ...
• Isolation and characterisation of a new hepatic bilirubin UDP-glucuronosyltransferase. Absence from Gunn rat liver.
• Pathogenicity of Xenorhabdus luminescens.
• Determination of protein size in chromatography column eluants by on-line photon correlation spectroscopy.
• Purification of two Clostridium bacteriocins by procedures appropriate to hydrophobic proteins.

Schools

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• Philhaven Hospital

• Point Loma College

• Dallas Theological Seminary

• Western Conservative Baptist Seminary

Procedures Preformed

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• Counseling Services
• Marital Counseling
• Marital Therapy
• Psychological Testing
• View All

Conditions Treated

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• Psychological Disorders
• Relationship Issues

Doctors Specialties

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• Clinical Psychology
• Counseling
• Obstetrics
• Gynecology

Accepted Insurances

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Awards

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• Fellow (FACOG)

Education

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• Wayne State University School of Medicine

Hospital

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• St. John Hospital and Medical Center

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