Aldo R. Castaneda Professor of Cardiovascular Research, Boston Children's Hospital
Internal Medicine
Dr. David E. Clapham, MD
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David Clapham practices Internal Medicine. He graduated from Emory University School of Medicine. Emory University School of Medicine is ranked 23/42 in Research/PrimaryCare. He has 2 awards "Elected Member" and "Investigator". Dr. David E. Clapham is a published MD. He published 100 publications, including: 'Naturally Produced Defensive Alkenal Compounds Activate TRPA1.'
Publications
- The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex.
- Naturally Produced Defensive Alkenal Compounds Activate TRPA1.
- Insights into the early evolution of animal calcium signaling machinery: A unicellular point of view.
- Early Evolution of the Eukaryotic Ca2+ Signaling Machinery: Conservation of the CatSper Channel Complex.
- The TRPM7 Chanzyme Is Cleaved to Release a Chromatin-Modifying Kinase.
- Structurally distinct ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility.
- Decreased Anxiety-Like Behavior and Gαq/11-Dependent Responses in the Amygdala of Mice Lacking TRPC4 Channels.
- Therapeutic Restoration of Spinal Inhibition via Druggable Enhancement of Potassium-Chloride Cotransporter KCC2-Mediated Chloride Extrusion in Peripheral Neuropathic P...
- Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1.
- Performance of a Redesigned HIV Selectest Enzyme-Linked Immunosorbent Assay Optimized To Minimize Vaccine-Induced Seropositivity in HIV Vaccine Trial Participants.
- Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1.
- TRPV3 Channels Mediate Strontium-Induced Mouse-Egg Activation.
- Direct recording and molecular identification of the calcium channel of primary cilia.
- Primary cilia are specialized calcium signalling organelles.
- EMRE is an Essential Component of the Mitochondrial Calcium Uniporter Complex.
- The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation.
- Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity.
- Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization.
- Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.
- Sperm patch-clamp.
- Rheotaxis guides Mammalian sperm.
- mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na(+) Channels to Adapt to Metabolic State.
- Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen.
- Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL.
- Cleavage of TRPM7 Releases the Kinase Domain from the Ion Channel and Regulates Its Participation in Fas-Induced Apoptosis.
- The channel kinase, TRPM7, is required for early embryonic development.
- A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels.
- POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.
- Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system.
- ATP-activated P2X2 current in mouse spermatozoa.
- Ancestral Ca2+ signaling machinery in early animal and fungal evolution.
- The Control of Male Fertility by Spermatozoan Ion Channels.
- TRPM7, the Mg(2+) Inhibited Channel and Kinase.
- International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family.
- An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1.
- Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption.
- TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation.
- Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter.
- Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development.
- Essential role for TRPC5 in amygdala function and fear-related behavior.
- Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst.
- Intracellular calcium strongly potentiates agonist-activated TRPC5 channels.
- A STIMulus Package puts orai calcium channels to work.
- TRPM1 forms ion channels associated with melanin content in melanocytes.
- Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis.
- TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane.
- The MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTP.
- Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons.
- Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta.
- Calcium signaling.
- Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice.
- CatSperbeta, a novel transmembrane protein in the CatSper channel complex.
- KSper, a pH-sensitive K+ current that controls sperm membrane potential.
- SnapShot: mammalian TRP channels.
- All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility.
- Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart.
- The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release.
- Bisandrographolide from Andrographis paniculata activates TRPV4 channels.
- CACNA1H mutations in autism spectrum disorders.
- Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels.
- Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow.
- An introduction to TRP channels.
- International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.
- International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels.
- International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.
- Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism.
- TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.
- TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/T...
- Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.
- SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation.
- The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus.
- A superfamily of voltage-gated sodium channels in bacteria.
- A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway.
- Symmetry, selectivity, and the 2003 Nobel Prize.
- CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm.
- The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.
- Formation of novel TRPC channels by complex subunit interactions in embryonic brain.
- TRPC5 is a regulator of hippocampal neurite length and growth cone morphology.
- Mechanism of persistent protein kinase D1 translocation and activation.
- Real-time imaging of nuclear permeation by EGFP in single intact cells.
- The cation selectivity filter of the bacterial sodium channel, NaChBac.
- Sorting out MIC, TRP, and CRAC ion channels.
- Signal transduction. Hot and cold TRP ion channels.
- A unified nomenclature for the superfamily of TRP cation channels.
- The mother of all endocytosis.
- Antitumor activity of ridaforolimus and potential cell-cycle determinants of sensitivity in sarcoma and endometrial cancer models.
- If you have health you have hope, if you have hope you have everything.
- Specific aspects of gastro-intestinal transit in children for drug delivery design.
- Lignin biosynthesis in transgenic Norway spruce plants harboring an antisense construct for cinnamoyl CoA reductase (CCR).
- Development of an isothermal heat-conduction photocalorimeter.
- A Norway spruce FLOWERING LOCUS T homolog is implicated in control of growth rhythm in conifers.
- Electronic tongue for pharmaceutical analytics: quantification of tastes and masking effects.
- Sparklebunnies are go!
- Spruce embryogenesis.
- LED-array photocalorimetry: instrument design and application to photostability of nifedipine.
- A promoter from the loblolly pine PtNIP1;1 gene directs expression in an early-embryogenesis and suspensor-specific fashion.
- Expression of the viviparous 1 (Pavp1) and p34cdc2 protein kinase (cdc2Pa) genes during somatic embryogenesis in Norway spruce (Picea abies [L.] Karst).
- An efficient protocol for genetic transformation and shoot regeneration of turmeric (Curcuma longa L.) via particle bombardment.
- A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists.
Schools
Emory University
Brigham and Women39s HospHarvard
Brigham and Women39s Hospital
Doctors Specialties
- Cardiology
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
- Investigator
Education
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Brigham and Women's Hospital -
Emory University School of Medicine
Hospital
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Boston Children's Hospital
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