Chairman Department of Neurology, Yale School of Medicine, Gilbert H. Glaser Professor of Neurology and Immunobiology and Professor Emeritus, Harvard Medical School
Neurology
Dr. David A. Hafler, MD
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Doctor David A. Hafler, MD practices Neurology. He attended University of Miami Miller School of Medicine. University of Miami Miller School of Medicine is ranked 45 in research and 0 in primary care medicine He received 4 awards: "CMS Meaningful Use Stage 1 Certification", "America's Top Doctors", "Boston Magazine" and "Boston Herald". Dr. David A. Hafler is a published doctor and has 91 publications published. The lastest was: 'Monoallelic expression of the human FOXP2 speech gene.'
Publications
- Systems immunology reveals markers of susceptibility to West Nile virus infection.
- TLR7 induces anergy in human CD4(+) T Cells.
- Prolonged Pro-Inflammatory Cytokine Production in Monocytes Following Influenza Vaccination is Modulated by IL-10 in Older Adults.
- Monoallelic expression of the human FOXP2 speech gene.
- Genetic and epigenetic fine mapping of causal autoimmune disease variants.
- Enhanced suppressor function of TIM-3(+) FoxP3(+) regulatory T Cells.
- Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.
- Regulatory T Cells in autoimmune neuroinflammation.
- Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses.
- Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms.
- pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires.
- Common genetic variants modulate pathogen-sensing responses in human dendritic Cells.
- A gene pathway analysis highlights the role of Cellular adhesion molecules in multiple sclerosis susceptibility.
- The plasticity of human Treg and Th17 Cells and its role in autoimmunity.
- Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects.
- The CD226/CD155 Interaction Regulates the Proinflammatory (Th1/Th17)/Anti-Inflammatory (Th2) Balance in Humans.
- Clinical relevance and functional consequences of the TNFRSF1A Multiple sclerosis locus.
- Analysis of immune-related loci identifies 48 new susceptibility variants for Multiple sclerosis.
- Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing- remitting Multiple sclerosis.
- PhIP-Seq characterization of autoantibodies from patients with Multiple sclerosis, type 1 diabetes and rheumatoid arthritis.
- Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 Cells.
- Immune-mediated disease genetics: the shared basis of pathogenesis.
- Polyfunctional responses by human T Cells result from sequential release of cytokines.
- The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+ T Cell Proliferation.
- Increased Frequencies of Myelin Oligodendrocyte Glycoprotein/MHC Class II-Binding CD4 Cells in Patients with Multiple Sclerosis.
- Identification of T helper type 1-like, Foxp3(+) regulatory T Cells in human autoimmune disease.
- Immunology. An innate role for IL-17.
- CD2 costimulation reveals defective activity by human CD4+CD25 hi regulatory Cells in patients with multiple sclerosis.
- Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery.
- A randomized controlled double-masked trial of albuterol add-on therapy in patients with Multiple sclerosis.
- TGF-beta induces IL-9 production from human Th17 Cells.
- Genome-wide association study in a high-risk isolate for Multiple sclerosis reveals associated variants in STAT3 gene.
- RNA interference screen in primary human T Cells reveals FLT3 as a modulator of IL-10 levels.
- On-chip activation and subsequent detection of individual antigen-specific T Cells.
- Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry.
- Engineered interleukin-2 antagonists for the inhibition of regulatory T Cells.
- Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 Cells.
- Age-dependent B Cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis.
- De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot.
- Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T Cells.
- Antibodies produced by clonally expanded plasma Cells in multiple sclerosis cerebrospinal fluid.
- Automated high-dimensional flow cytometric data analysis.
- IL-17-producing human peripheral regulatory T Cells retain suppressive function.
- The role of the CD58 locus in Multiple sclerosis.
- Soluble IL-2RA levels in Multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses.
- TIMs: central regulators of immune responses.
- Multiple sclerosis and regulatory T Cells.
- Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies.
- Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss.
- TIM-4 expressed on APCs induces T Cell expansion and survival.
- Lack of TIM-3 immunoregulation in Multiple sclerosis.
- Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation.
- The developing mosaic of autoimmune disease risk.
- Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.
- Allelic variant in CTLA4 alters T Cell phosphorylation patterns.
- Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune Cells.
- A second major histocompatibility complex susceptibility locus for Multiple sclerosis.
- Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein.
- A local antigen-driven humoral response is present in the inflammatory myopathies.
- New therapeutic approaches for Multiple sclerosis.
- Alterations in CD46-mediated Tr1 regulatory T Cells in patients with multiple sclerosis.
- A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.
- Dysregulated T Cell expression of TIM3 in multiple sclerosis.
- The purification and functional analysis of human CD4+CD25high regulatory T Cells.
- MHC class II expression identifies functionally distinct human regulatory T Cells.
- Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T Cells.
- Loss of IL-4 secretion from human type 1a diabetic pancreatic draining lymph node NKT Cells.
- A whole-genome admixture scan finds a candidate locus for Multiple sclerosis susceptibility.
- Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein.
- Characterization of in vivo expanded OspA-specific human T-Cell clones.
- Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T Cells.
- High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic Multiple sclerosis model.
- Suppressor T Cells in human diseases.
- Cross-reactive TCR responses to self antigens presented by different MHC class II molecules.
- PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T Cells.
- T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 Cells and in cerebrospinal fluid-derive...
- An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T Cells.
- A high-density admixture map for disease gene discovery in african americans.
- Methods for high-density admixture mapping of disease genes.
- Loss of functional suppression by CD4+CD25+ regulatory T Cells in patients with multiple sclerosis.
- Human CD4+CD25+ regulatory T Cells.
- Rapamycin-resistant proliferation of CD8+ T Cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-...
- Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T Cell function.
- Activated CD8+ T Cells in secondary progressive MS secrete lymphotoxin.
- Inhibition of human CD4(+)CD25(+high) regulatory T Cell function.
- Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T Cells.
- GAD65-reactive T Cells are activated in patients with autoimmune type 1a diabetes.
- Degeneracy, as opposed to specificity, in immunotherapy.
- Microbial reprogramming inhibits Western diet-associated obesity.
- Models of Somatic Hypermutation Targeting and Substitution Based on Synonymous Mutations from High-Throughput Immunoglobulin Sequencing Data.
Schools
University Of Miami School Of Medicine
Johns Hopkins Hospital
Ny Hospcornell Med Center
Harvard Med School
Procedures Preformed
- Lumbar Puncture
Conditions Treated
- Ataxia
- Giant Cell Arteritis
- Multiple Sclerosis (MS)
- Sleep Apnea
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Doctors Specialties
- Neurology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- America's Top Doctors
- Boston Magazine
- Boston Herald
Education
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New York Presbyterian Hospital - Cornell Campus -
Johns Hopkins University -
University of Miami Miller School of Medicine
Hospital
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Yale-New Haven Hospital
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