Physician
Otolaryngology (ENT)
Dr. David A. Brian, MD
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David Brian practices Otolaryngology (ENT). He studied medicine at Jefferson Medical College. He over the years received 1 awards: "Fellow (FAAO-HNS)". David Brian is a published doctor and has 70 publications published. The lastest was: 'Coronavirus genomic and subgenomic minus-strand RNAs copartition in membrane-protected replication complexes.'
Publications
- Dependence of Coronavirus RNA Replication on an NH2-terminal Partial Nonstructural Protein 1 in cis.
- Reselection of a genomic upstream open reading frame in mouse hepatitis coronavirus 5'-untranslated-region mutants.
- An Optimal cis-Replication Stem-Loop IV in the 5' Untranslated Region of the Mouse Coronavirus Genome Extends 16 Nucleotides into Open Reading Frame 1.
- Subgenomic messenger RNA amplification in coronaviruses.
- Bovine coronavirus nonstructural protein 1 (p28) is an RNA binding protein that binds terminal genomic cis-replication elements.
- An RNA stem-loop within the bovine coronavirus nsp1 coding region is a cis-acting element in defective interfering RNA replication.
- 5'-proximal hot spot for an inducible positive-to-negative-strand template switch by coronavirus RNA-dependent RNA polymerase.
- Bovine coronavirus 5'-proximal genomic acceptor hotspot for discontinuous transcription is 65 nucleotides wide.
- Stem-loop IV in the 5' untranslated region is a cis-acting element in bovine coronavirus defective interfering RNA replication.
- Common RNA replication signals exist among group 2 coronaviruses: evidence for in vivo recombination between animal and human coronavirus molecules.
- Stem-loop III in the 5' untranslated region is a cis-acting element in bovine coronavirus defective interfering RNA replication.
- Detection of coronavirus RNA and antigen in multiple sclerosis brain.
- Nucleotide sequence of the porcine transmissible gastroenteritis coronavirus matrix protein gene.
- Bovine coronavirus hemagglutinin protein.
- Methylation of high-molecular-weight subunit RNA of feline leukemia virus.
- Properties of feline leukemia virus. III. Analysis of the RNA.
- Bovine coronavirus structural proteins.
- TempOral regulation of RNA synthesis of bovine coronavirus.
- Sequencing DNA amplified directly from a bacterial colony.
- Molecular cloning of complementary DNA from a pneumopathic strain of bovine viral diarrhea virus and its diagnostic application.
- Sequencing PCR DNA amplified directly from a bacterial colony.
- A PCR-enhanced method for determining the 5' end sequence of mRNAs.
- Oligonucleotide fingerprints of antigenically related bovine coronavirus and human coronavirus OC43.
- The Coronaviridae now comprises two genera, coronavirus and torovirus: report of the Coronaviridae Study Group.
- Antigenic relationships among proteins of bovine coronavirus, human respiratory coronavirus OC43, and mouse hepatitis coronavirus A59.
- TempOral regulation of bovine coronavirus RNA synthesis.
- Sequence analysis of the porcine transmissible gastroenteritis coronavirus nucleocapsid protein gene.
- Nucleotide sequence between the peplomer and matrix protein genes of the porcine transmissible gastroenteritis coronavirus identifies three large open reading frames.
- Coronavirus cell-associated RNA-dependent RNA polymerase.
- Diagnosis of porcine and bovine enteric coronavirus infections using cloned cDNA probes.
- Recommendations of the Coronavirus Study Group for the nomenclature of the structural proteins, mRNAs, and genes of coronaviruses.
- The amino-terminal signal peptide on the porcine transmissible gastroenteritis coronavirus matrix protein is not an absolute requirement for membrane translocation and...
- Synthesis and processing of the bovine enteric coronavirus haemagglutinin protein.
- Glycosylation of the bovine coronavirus hemagglutinin protein.
- Sequence analysis of the bovine coronavirus nucleocapsid and matrix protein genes.
- Deduced amino acid sequence and potential O-glycosylation sites for the bovine coronavirus matrix protein.
- RNA-dependent RNA polymerase activity in coronavirus- infected cells.
- Coronavirus subgenomic replicons as a mechanism for mRNA amplification.
- Structure and expression of the bovine coronavirus hemagglutinin protein.
- Genome of porcine transmissible gastroenteritis virus.
- Nidovirus genome replication and subgenomic mRNA synthesis. Pathways followed and cis-acting elements required.
- Role of subgenomic minus-strand RNA in coronavirus replication.
- Coronavirus genome structure and replication.
- Downstream ribosomal entry for translation of coronavirus TGEV gene 3b.
- Tandem placement of a coronavirus promoter results in enhanced mRNA synthesis from the downstream-most initiation site.
- Precise large deletions by the PCR-based overlap extension method.
- Bovine coronavirus genome.
- Minus-strand copies of replicating coronavirus mRNAs contain antileaders.
- Coronavirus subgenomic minus-strand RNAs and the potential for mRNA replicons.
- Structure and orientation of expressed bovine coronavirus hemagglutinin-esterase protein.
- Deduced sequence of the bovine coronavirus spike protein and identification of the internal proteolytic cleavage site.
- The 9-kDa hydrophobic protein encoded at the 3' end of the porcine transmissible gastroenteritis coronavirus genome is membrane-associated.
- Leader-mRNA junction sequences are unique for each subgenomic mRNA species in the bovine coronavirus and remain so throughout persistent infection.
- Bovine coronavirus mRNA replication continues throughout persistent infection in cell culture.
- Coronavirus genomic and subgenomic minus-strand RNAs copartition in membrane-protected replication complexes.
- The 5' end of coronavirus minus-strand RNAs contains a short poly(U) tract.
- Sequence and expression analysis of potential nonstructural proteins of 4.9, 4.8, 12.7, and 9.5 kDa encoded between the spike and membrane protein genes of the bovine ...
- The major product of porcine transmissible gastroenteritis coronavirus gene 3b is an integral membrane glycoprotein of 31 kDa.
- Bovine coronavirus I protein synthesis follows ribosomal scanning on the bicistronic N mRNA.
- cis Requirement for N-specific protein sequence in bovine coronavirus defective interfering RNA replication.
- The UCUAAAC promoter motif is not required for high-frequency leader recombination in bovine coronavirus defective interfering RNA.
- An intraleader open reading frame is selected from a hypervariable 5' terminus during persistent infection by the bovine coronavirus.
- A cis-acting function for the coronavirus leader in defective interfering RNA replication.
- Evidence for a pseudoknot in the 3' untranslated region of the bovine coronavirus genome.
- The nucleocapsid protein gene of bovine coronavirus is bicistronic.
- Downstream sequences influence the choice between a naturally occurring noncanonical and closely positioned upstream canonical heptameric fusion motif during bovine co...
- A phylogenetically conserved hairpin-type 3' untranslated region pseudoknot functions in coronavirus RNA replication.
- Translation from the 5' untranslated region (UTR) of mRNA 1 is repressed, but that from the 5' UTR of mRNA 7 is stimulated in coronavirus-infected cells.
- A translation-attenuating intraleader open reading frame is selected on coronavirus mRNAs during persistent infection.
Schools
Jefferson Medical College Of Thomas Jefferson University Thomas Jefferson University
Akron Genl Hospital
Bon Secours Hospital
Henry Ford Hospital
Procedures Preformed
- Excision or Destruction of Palate or Uvula Lesion
- Glossectomy
- Intranasal or Sinus Procedure
- Laryngoscopy - Laryngotomy - Laryngectomy - Pharyngolaryngectomy - Pharyngectomy
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Conditions Treated
- Dizziness
- ENT Cancer
- Gastroesophageal Reflux Disease (GERD)
- Oral Cancer
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Doctors Specialties
- Ear, Nose, and Throat
- Otolaryngology (ENT)
Accepted Insurances
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- CoreSource
- Coventry Health Care
- Medicare MCR
Awards
- Fellow (FAAO-HNS)
Education
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Henry Ford Hospital - Wayne State University -
Akron General Medical Center -
Jefferson Medical College
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