Professor of Pediatrics, University Colorado
Pediatric Hematology & Oncology
Dr. Daniel R. Ambruso, MD
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Daniel R. Ambruso is an expert in the field of Pediatric Hematology & Oncology. He studied medicine at University of Rochester School of Medicine and Dentistry. He received awards:"Regional Top Doctor". Daniel R. Ambruso is a published doctor and has 95 publications published. The lastest was: 'In vivo treatment with granulocyte colony-stimulating factor results in divergent effects on neutrophil functions measured in vitro.'
Publications
- Red cell exchange transfusion halts progressive proliferative Sickle cell retinopathy in a teenaged patient with hemoglobin SC disease.
- Effect of Cord Blood Processing on Transplant Outcomes after Single Myeloablative Umbilical Cord Blood Transplantation.
- One size will never fit all: the future of research in pediatric transfusion medicine.
- Spectra Optia granulocyte apheresis collections result in higher collection efficiency of viable, functional neutrophils in a randomized, crossover, multicenter trial.
- Hydroxyethyl starch and granulocyte transfusions: considerations of utility and toxicity profile for patients and donors.
- Transfusion complications in thalassemias.
- Proteomic analysis of the supernatant of red blood Cell units: the effects of storage and leucoreduction.
- How do we teach pediatric topics in transfusion medicine: curriculum development, learners, and instructional strategies.
- Platelet Vascular Endothelial Growth Factor is a Potential Mediator of Transfusion-Related Acute Lung Injury.
- A case of autoimmune hemolytic Anemia with anti-D specificity in a 1-year-old child.
- Peroxiredoxin-6 and NADPH oxidase activity.
- The effects of premature delivery on subsequent development of the rat.
- Hyperzincemia in a patient with pyoderma gangrenosum.
- The rise in the total iron-binding capacity after iron overdose.
- Failure of a pan-reactive anti-T Cell antibody, OKT 3, to prevent graft versus host disease in severe combined immunodeficiency.
- Transfusion-associated transmission of human T-lymphotropic virus types I and II: experience of a regional blood center.
- Microchimerism and tolerance following intrauterine transplantation and transfusion for alpha-thalassemia-1.
- Reduced mobilization of CD34+ stem Cells in advanced human immunodeficiency virus type 1 disease.
- Changes in human immunodeficiency virus type 1 virus load during mobilization and harvesting of hemopoietic progenitor Cells. Adult AIDS Clinical Trials Group 285 Stud...
- Racial and ethnic composition of volunteer cord blood donors: comparison with volunteer unrelated marrow donors.
- Parvovirus-associated aplastic crisis in a patient with red blood Cell glucose-6-phosphate dehydrogenase deficiency.
- Successful allogeneic hematopoietic stem Cell transplantation (HSCT) for Shwachman-Diamond syndrome.
- Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils.
- In vivo treatment with granulocyte colony-stimulating factor does not delay apoptosis in human neutrophils by increasing the expression of the vacuolar proton ATPase.
- CP-64131, an aminobenzazepine with cytokine-like properties, stimulates human neutrophil functions through the p38-MAPK pathway.
- NADPH oxidase activity of neutrophil specific granules: requirements for cytosolic components and evidence of assembly during Cell activation.
- Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophages.
- Formyl-Met-Leu-Phe induces calcium-dependent tyrosine phosphorylation of Rel-1 in neutrophils.
- Lysophosphatidylcholines prime the NADPH oxidase and stimulate multiple neutrophil functions through changes in cytosolic calcium.
- Transfusion-related acute lung injury: definition and review.
- Oxidase activity in cord blood neutrophils: a balance between increased membrane associated cytochrome b558 and deficient cytosolic components.
- Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors.
- A 29-kDa protein associated with p67phox expresses both peroxiredoxin and phospholipase A2 activity and enhances superoxide anion production by a Cell-free system of N...
- Peroxiredoxin 6 translocates to the plasma membrane during neutrophil activation and is required for optimal NADPH oxidase activity.
- Extended red blood cell antigen matching for transfusions in Sickle cell disease: a review of a 14-year experience from a single center (CME).
- Generation of neutrophil priming activity by cell-containing blood components treated with pathogen reduction technology and stored in Platelet additive solutions.
- Long term G-CSF-induced remission of ulcerative colitis-like inflammatory bowel Disease in a patient with glycogen storage Disease Ib and evaluation of associated neut...
- Phthalate esters used as plasticizers in packed red blood Cell storage bags may lead to progressive toxin exposure and the release of pro-inflammatory cytokines.
- Evidence of knowledge acquisition in a cognitive flexibility-based computer learning environment.
- Consensus recommendations of pediatric transfusion medicine objectives for clinical pathology residency training programs.
- Lack of antibody formation to Platelet neoantigens after transfusion of riboflavin and ultraviolet light-treated Platelet concentrates.
- The effect of storage on the accumulation of oxidative biomarkers in donated packed red blood Cells.
- Pediatric transfusion medicine: development of a critical mass.
- West Nile viremic blood donors and risk factors for subsequent West Nile fever.
- Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial Cells in a two-ev...
- Hemolytic Disease of the newborn caused by a high titer anti-group B IgG from a group A mother.
- Hypotension and acute pulmonary insufficiency following transfusion of autologous red blood Cells during surgery: a case report and review of the literature.
- Electron spin echo envelope modulation evidence for carbonate binding to iron(III) and copper(II) transferrin and lactoferrin.
- Assembly and activation of the NADPH:O2 oxidoreductase in human neutrophils after stimulation with phorbol myristate acetate.
- Clinical features of a human Rac2 mutation: a complex neutrophil dysfunction Disease.
- The effect of leukocyte-reduction method on the amount of human cytomegalovirus in blood products: a comparison of apheresis and filtration methods.
- Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.
- Transfusion-related acute lung injury and granulocytes from stored packed RBCs.
- Functional characteristics of neutrophils collected and stored after administration of G-CSF.
- Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation.
- In vivo treatment with granulocyte colony-stimulating factor results in divergent effects on neutrophil functions measured in vitro.
- In vitro release of vascular endothelial growth factor during Platelet aggregation.
- The effects of stem Cell factor and granulocyte colony stimulating factor therapy on the activity of the neutrophil NADPH oxidase enzyme system.
- Plasma and lipids from stored packed red blood Cells cause acute lung injury in an animal model.
- Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann Thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex.
- The association of biologically active lipids with the development of transfusion-related acute lung injury: a retrospective study.
- Neutrophils from patients after burn injury express a deficiency of the oxidase components p47-phox and p67-phox.
- Platelets and neutrophils from healthy term neonates exhibit increased levels of immunoglobulins.
- Analysis of the priming activity of lipids generated during routine storage of Platelet concentrates.
- Compounds biologically similar to Platelet activating factor are present in stored blood components.
- Flow cytometric analysis of residual white blood cell concentration and Platelet activation antigens in double filtered Platelet concentrates.
- Partial characterization of lipids that develop during the routine storage of blood and prime the neutrophil NADPH oxidase.
- Successful treatment of lymphohistiocytic reticulosis with phagocytosis with epipodophyllotoxin VP 16-213.
- Inherited antithrombin III deficiency and cerebral thrombosis in a child.
- Effect of subcutaneous deferoxamine and oral vitamin C on iron excretion in congenital hypoplastic Anemia and refractory Anemia associated with the 5q-syndrome.
- Antithrombin III deficiency: decreased synthesis of a biochemically normal molecule.
- Lactoferrin enhances hydroxyl radical production by human neutrophils, neutrophil particulate fractions, and an enzymatic generating system.
- Delayed marrow aplasia following treatment for thymic hypoplasia: correction by marrow transplant without immunosuppression.
- Defective bactericidal activity and absence of specific granules in neutrophils from a patient with recurrent bacterial infections.
- Oxidative metabolism of cord blood neutrophils: relationship to content and degranulation of cytoplasmic granules.
- WEB2170, a specific Platelet-activating factor antagonist, attenuates neutrophil priming by human serum after clinical burn injury: the 1991 Moyer Award.
- Stored blood components contain agents that prime the neutrophil NADPH oxidase through the Platelet-activating-factor receptor.
- Factor VIII and renal Disease.
- Iron studies in sickle cell Anemia.
- Defective oxidative metabolism in newborn neutrophils: discrepancy between superoxide anion and hydroxyl radical generation.
- Fulminant hepatic neoplasia after androgen therapy.
- Orthotopic liver transplantation for acute fulminant Wilson Disease.
- Infectious and bleeding complications in patients with glycogenosis Ib.
- NADPH-dependent antibacterial activity in subCellular fractions of human neutrophils: interaction with granule constituents.
- Experience with donors matched for minor blood group antigens in patients with sickle cell Anemia who are receiving chronic transfusion therapy.
- Pancytopenia in propionic acidemia: hematologic evaluation and studies of hematopoiesis in vitro.
- Measurement of adenosine triphosphate and 2,3-diphosphoglycerate in stored blood with 31P nuclear magnetic resonance spectroscopy.
- Inhibition of colony-stimulating factor (CSF) production by postburn serum: negative feedback inhibition mediated by lactoferrin.
- Lack of effect of lithium carbonate in patients with glycogenosis Ib.
- Increased activity of the respiratory burst in cord blood neutrophils: kinetics of the NADPH oxidase enzyme system in subCellular fractions.
- Oxidative metabolism in cord blood monocytes and monocyte-derived macrophages.
- Intranasal administration of deferoxamine to iron overloaded patients.
- Comparison of the electron spin echo envelope modulation (ESEEM) for human lactoferrin and transferrin complexes of copper(II) and vanadyl ion.
- Hyponatremia and seizures in young children given DDAVP.
Schools
University Of Rochester School Of Medicine and Dentistry
Case Western Reserve University Metrohealth Program
National Jewish Medical and Research Center
University Of Colorado
Conditions Treated
- Anemia
- Coagulation Disorders (incl. Hemophilia)
- Immune Thrombocytopenic Purpura (ITP)
- Neutropenia
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Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- Regional Top Doctor
Education
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University of Colorado -
Case Western Reserve University - University Hospitals -
University of Rochester School of Medicine and Dentistry
Hospital
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University of Colorado Hospital -
Children's Hospital Colorado
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