Director, Preventive Cardiology
Internal Medicine
Dr. Daniel J. Rader, MD
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Daniel Rader is an expert in the field of Internal Medicine. He received 6 awards: "Philadelphia Magazine", "America's Top Doctors", "CMS Meaningful Use Stage 1 Certification", "Elected Member", "Women's Health" and "Super Doctor". Daniel Rader has written publications. He has 101 publications published with PubMed. The lastest publication is: 'Therapeutic Targets of Triglyceride Metabolism as Informed by Human Genetics.'
Publications
- Cholesteryl Ester Transfer Protein Inhibition With Anacetrapib Increases Fractional Clearance Rates of High-Density Lipoprotein Apolipoprotein A-I and Plasma Cholester...
- Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.
- Therapeutic Targets of Triglyceride Metabolism as Informed by Human Genetics.
- Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study.
- Nonstatin Low-Density Lipoprotein-Lowering Therapy and Cardiovascular Risk Reduction-Statement From ATVB Council.
- A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation.
- Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib.
- Potent peroxisome proliferator-activated receptor-α agonist treatment increases cholesterol efflux capacity in humans with the metabolic syndrome.
- Tribbles-1: a novel regulator of hepatic lipid metabolism in humans.
- Microsomal Triglyceride Transfer Protein Transfers and Determines Plasma Concentrations of Ceramide and Sphingomyelin but Not Glycosylceramide.
- HDL-cholesterol and cardiovascular disease: rethinking our approach.
- Serum lipid expression correlates with function and regeneration following living donor liver transplantation.
- Serum Fractalkine (CX3CL1) and Cardiovascular Outcomes and Diabetes: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.
- Triglyceride-rich lipoproteins and coronary artery disease risk: new insights from human genetics.
- Macrophage Sortilin Promotes LDL Uptake, Foam Cell Formation, and Atherosclerosis.
- Knockout of Adamts7, A Novel CAD Locus in Humans, Reduces Atherosclerosis in Mice.
- Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction.
- Effects of niacin, statin, and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 levels in patients with dyslipidemia.
- Accelerating the pace of atherosclerosis research.
- Exome Sequencing in Suspected Monogenic Dyslipidemias.
- Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.
- Sortilin and lipoprotein metabolism: making sense out of complexity.
- Dyslipidaemia: Cardiovascular prevention-end of the road for niacin?
- High-density lipoproteins in the prevention of cardiovascular disease: changing the paradigm.
- Spotlight on HDL biology: new insights in metabolism, function and translation.
- AAV Vectors Expressing LDLR Gain-of-Function Variants Demonstrate Increased Efficacy in Mouse Models of Familial Hypercholesterolemia.
- CPAP, weight loss, or both for obstructive sleep apnea.
- A novel ApoA-I truncation (ApoA-IMytilene) associated with decreased ApoA-I production.
- Genetics of lipid traits: Genome-wide approaches yield new biology and clues to causality in coronary artery disease.
- New Therapies for Coronary Artery Disease: Genetics Provides a Blueprint.
- Lipoproteins as biomarkers and therapeutic targets in the setting of acute coronary syndrome.
- Relation of Serum Lipids and Lipoproteins with Progression of CKD: The CRIC Study.
- Apolipoprotein a-I and cholesterol efflux: the good, the bad, and the modified.
- Genetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis.
- Differential Association of Plasma Angiopoietin-Like Proteins 3 and 4 With Lipid and Metabolic Traits.
- Lomitapide and Mipomersen: Two First-in-Class Drugs for Reducing Low-Density Lipoprotein Cholesterol in Patients With Homozygous Familial Hypercholesterolemia.
- Catch 5/8: Opposing effects of ABCG5/8 function on myocardial infarction and gallstone disease.
- Decreased cholesterol efflux capacity and atherogenic lipid profile in young women with PCOS.
- Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.
- Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci.
- Statin Therapy in Heart Failure: Is It Time for a Second Look?
- Psoriasis is associated with decreased plasma adiponectin levels independently of cardiometabolic risk factors.
- Higher plasma CXCL12 levels predict incident myocardial infarction and death in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort study.
- Monogenic causes of elevated HDL cholesterol and implications for development of new therapeutics.
- Discovery and refinement of loci associated with lipid levels.
- Common variants associated with plasma triglycerides and risk for coronary artery disease.
- Genetics of lipid traits and relationship to coronary artery disease.
- Biodistribution of AAV8 vectors expressing human LDL receptor in a mouse model of homozygous familial hypercholesterolemia.
- Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia.
- Candidate Gene Association Study of Coronary Artery Calcification in Chronic Kidney Disease: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort).
- Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium.
- A coding variant in SR-BI (I179N) significantly increases atherosclerosis in mice.
- The Addition of Niacin to Statin Therapy Improves High-density Lipoprotein Cholesterol Levels but not Metrics of Functionality.
- Measurement of apo(a) kinetics in human subjects using a microfluidic device with tandem mass spectrometry.
- Lymphatics as a new active player in reverse cholesterol transport.
- Anti-oxidative and cholesterol efflux capacities of high-density lipoprotein are reduced in ischaemic cardiomyopathy.
- Microsomal transfer protein inhibition in humans.
- Apolipoprotein E-mediated cell cycle arrest linked to p27 and the Cox2-dependent repression of miR221/222.
- Loci influencing blood pressure identified using a cardiovascular gene-centric array.
- Molecular Mechanisms Responsible for the Differential Effects of ApoE3 and ApoE4 on Plasma Lipoprotein-Cholesterol Levels.
- Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India.
- Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous fami...
- Mighty minipig in fight against cardiovascular disease.
- Implementing genomic medicine in the clinic: the future is here.
- Measurement of waist circumference predicts coronary atherosclerosis beyond plasma adipokines.
- Gene-centric meta-analysis of lipid traits in african, East asian and Hispanic populations.
- Targeting high density lipoproteins in the prevention of cardiovascular disease?
- Effect of interleukin 1ò inhibition in cardiovascular disease.
- Cardiovascular Protection by ApoE and ApoE-HDL Linked to Suppression of ECM Gene Expression and Arterial Stiffening.
- Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase...
- Prediabetic Obese Adolescents have a More Atherogenic Lipoprotein Profile Compared with Normoglycemic Obese Peers.
- Endothelial function and weight loss:Comparison of low-carbohydrate and low-fat diets.
- Approach to the Patient with Extremely Low HDL-Cholesterol.
- Extended-Release Niacin Acutely Suppresses Postprandial Triglyceridemia.
- Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis.
- High-Density Lipoprotein Particle Number: A Better Measure to Quantify High-Density Lipoprotein?
- Sortilin as a Regulator of Lipoprotein Metabolism.
- Measurement of Fractional Synthetic Rates of Multiple Protein Analytes by Triple Quadrupole Mass Spectrometry.
- IL-1 and atherosclerosis: a murine twist to an evolving human story.
- The Evolution and Refinement of Traditional Risk Factors for Cardiovascular Disease.
- Design and synthesis of boronic acid inhibitors of endothelial lipase.
- Mining the LIPG Allelic Spectrum Reveals the Contribution of Rare and Common Regulatory Variants to HDL Cholesterol.
- The anti-oxidative capacity of high-density lipoprotein is reduced in acute coronary syndrome but not in stable coronary artery disease.
- HDL Functionality: How Do We Measure It and Is It Relevant for Everyday Clinical Practice?
- Underdiagnosis and undertreatment of cardiovascular risk factors in patients with moderate to severe psoriasis.
- Adipose modulation of high-density lipoprotein cholesterol: implications for obesity, high-density lipoprotein metabolism, and cardiovascular disease.
- Novel In Vivo Method for Measuring Cholesterol Mass Flux in Peripheral Macrophages.
- A Gaussian copula approach for the analysis of secondary phenotypes in case-control genetic association studies.
- Pharmacologic Suppression of Hepatic ATP-Binding Cassette Transporter 1 Activity in Mice Reduces High-Density Lipoprotein Cholesterol Levels but Promotes Reverse Chole...
- Fluorescent green plaques: light at the end of the catheter?
- Familial hypercholesterolemia: screening, diagnosis and management of pediatric and adult patients: clinical guidance from the National Lipid Association Expert Panel ...
- Familial hypercholesterolemias: prevalence, genetics, diagnosis and screening recommendations from the National Lipid Association Expert Panel on Familial Hypercholest...
- Identification and functional characterization in vivo of a novel functional splice variant of LDLR in rhesus macaques.
- A Genome-wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease.
- A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility.
- Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression.
- Adiponectin Is Associated with Favorable Lipoprotein Profile, Independent of BMI and Insulin Resistance, in Adolescents.
- Familial Hypercholesterolemia: Screening, diagnosis and management of pediatric and adult patients Clinical guidance from the National Lipid Association Expert Panel o...
- Metabolic Syndrome, Components, and Cardiovascular Disease Prevalence in Chronic Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study.
- Dense Genotyping of Candidate Gene Loci Identifies Variants Associated With High-Density Lipoprotein Cholesterol.
Schools
Medical College of Pennsylvania
Yale New Haven Hospital
Doctors Specialties
- Internal Medicine
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Personal Choice PPO
- Regional Pref Network EPO
- Regional Pref Network HMO
- Regional Pref Network HMO+
- Regional Pref Network POS+
- Regional Pref Network PPO
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- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- CoreSource
- Coventry Health America PPO
- Coventry Health Care of Delaware PPO
- First Health (Coventry Health Care) PPO
- Geisinger Health Plan
- Community Blue PPO
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- Horizon Blue Cross Blue Shield HMO
- Horizon Blue Cross Blue Shield POS
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- QualCare PPO
- Tricare
- Choice Plus POS
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- Navigate POS
- Options PPO
- Oxford Liberty
- United Healthcare
Awards
- Philadelphia Magazine
- America's Top Doctors
- CMS Meaningful Use Stage 1 Certification
- Elected Member
- Women's Health
- Super Doctor
Education
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Yale New Haven Children's Center
Hospital
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Hospital of the University of Pennsylvania -
Penn Presbyterian Medical Center
Drug Facts
| NPI NUMBER | 1316979610 | |
| NPPES Provider LastName | RADER | |
| NPPES Provider FirstName | DANIEL | |
| NPPES Provider ZIPCode | 19104 | |
| NPPES Provider State | PA | |
| Specialty Description | Internal Medicine | |
| Total Claim Count | 395.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1316979610 |
| Last Name Of The Provider | RADER |
| First Name Of The Provider | DANIEL |
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