Professor, Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
Infectious Disease
Dr. Dan H. Barouch, MD
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Dan H. Barouch practices Infectious Disease. He researched medicine at Harvard Medical School. Harvard Medical School is a top medical university. Harvard Medical School is ranked 1 in research and 12 in primary care medicine Barouch is a published doctor and has 101 publications published. The lastest was: 'SIV Infection-Mediated Changes in Gastrointestinal Bacterial Microbiome and Virome Are Associated with Immunodeficiency and Prevented by Vaccination.'
Publications
- Immunization of HIV-1-infected Persons with Autologous Dendritic Cells Transfected with mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Cl...
- Transient CD4+ T cell depletion results in the delayed development of functional vaccine-elicited antibody responses.
- Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology.
- Attenuation of Replication-Competent Adenovirus Serotype 26 Vaccines by Vectorization.
- Antigen-specific NK cell memory in rhesus macaques.
- Induction of HIV-1-specific mucosal immune responses following intramuscular recombinant adenovirus serotype 26 HIV-1 vaccination of humans.
- Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection.
- A method for high-throughput, sensitive analysis of IgG Fc and Fab glycosylation by capillary electrophoresis.
- Generation and Evaluation of Clade C Simian-Human Immunodeficiency Virus Challenge Stocks.
- A Multivalent Clade C HIV-1 Env Trimer Cocktail Elicits a Higher Magnitude of Neutralizing Antibodies than Any Individual Component.
- Quantification of the epitope diversity of HIV-1-specific binding antibodies by peptide microarrays for global HIV-1 vaccine development.
- Accelerating HIV-1 Vaccine Efficacy Trials.
- Construction and Evaluation of Novel Rhesus Monkey Adenovirus Vaccine Vectors.
- Common Features of Mucosal and Peripheral Vaccine-Elicited Antibody Responses in Rhesus Monkeys.
- A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 vaccine.
- Late Endosomal Trafficking of Alternative Serotype Adenovirus Vaccine Vectors Augments Antiviral Innate Immunity.
- Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys.
- Design of Lipid Nanocapsule Delivery Vehicles for Multivalent Display of Recombinant Env Trimers in HIV Vaccination.
- Characterization and Immunogenicity of a Novel Mosaic M HIV-1 gp140 Trimer.
- Longitudinal Requirement for CD4+ T Cell Help for Adenovirus Vector-Elicited CD8+ T Cell Responses.
- Hexon Hypervariable Region-Modified Adenovirus 5 Vectors Display Reduced Hepatotoxicity but Induce T Lymphocyte Phenotypes Similar to Ad5 Vectors.
- A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 Vaccine: Evidence for transient t cell responses in peripheral blo...
- The Immune Space: A Concept and Template for Rationalizing Vaccine Development.
- First-in-Human Evaluation of a Hexon Chimeric Adenovirus Vector Expressing HIV-1 Env (IPCAVD 002).
- Augmented replicative capacity of the boosting antigen improves the protective efficacy of heterologous prime-boost vaccine regimens.
- Comparison of multiple adjuvants on the stability and immunogenicity of a clade C HIV-1 gp140 trimer.
- Adenovirus Serotype 26 and 35 Vectors Induce SIV-Specific T Lymphocyte Responses in Foreskin in Rhesus Monkeys.
- The Canarypox Vector ALVAC Induces Distinct Cytokine Responses Compared to the Vaccinia-Based Vectors MVA and NYVAC in Rhesus Monkeys.
- The quest for an HIV-1 vaccine--moving forward.
- Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys.
- Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys.
- Nonreplicating vectors in HIV vaccines.
- Generation of effector memory T cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccination.
- A global approach to HIV-1 vaccine development.
- Comparative characterization of transfection- and infection-derived simian immunodeficiency virus challenge stocks for in vivo nonhuman primate studies.
- Attenuated Listeria monocytogenes Vector Primes More Potent SIV-Specific Mucosal Immunity than DNA Vaccines in Mice.
- Comparative analysis of simian immunodeficiency virus Gag-specific effector and memory CD8(+) T cells induced by different adenovirus vectors.
- Hepatitis C genotype 1 mosaic vaccines are immunogenic in mice and induce stronger T-cell responses than natural strains.
- Characterization of humoral and cellular immune responses elicited by a recombinant adenovirus serotype 26 HIV-1 Env vaccine in healthy adults (IPCAVD 001).
- First-in-human evaluation of the safety and immunogenicity of a recombinant adenovirus serotype 26 HIV-1 Env vaccine (IPCAVD 001).
- Polymer multilayer tattooing for enhanced DNAÂ vaccination.
- Alternative serotype adenovirus vaccine vectors elicit memory T cells with enhanced anamnestic capacity compared to Ad5 vectors.
- Full-length HIV-1 immunogens induce greater magnitude and comparable breadth of T lymphocyte responses to conserved HIV-1 regions compared with conserved-region-only H...
- Accelerated Heterologous Adenovirus Prime-Boost SIV Vaccine in Neonatal Rhesus Monkeys.
- Preexisting adenovirus seropositivity is not associated with increased HIV-1 acquisition in three HIV-1 vaccine efficacy trials.
- Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys.
- Focus and breadth of cellular immune responses elicited by a heterologous insert prime-boost vaccine regimen in rhesus monkeys.
- Adenovirus Serotype 5 Neutralizing Antibodies Target Both Hexon and Fiber Following Vaccination and Natural Infection.
- Ad5-Specific Neutralizing Antibodies Target Multiple Hexon Hypervariable Regions.
- Durable mucosal simian immunodeficiency virus-specific effector memory T lymphocyte responses elicited by recombinant adenovirus vectors in rhesus monkeys.
- Vitamin a deficiency impairs vaccine-elicited gastrointestinal immunity.
- Pillars article: phenotypic analysis of antigen-specific T lymphocytes. Science. 1996. 274: 94-96.
- Mosaic HIV-1 Gag Antigens Can Be Processed and Presented to Human HIV-Specific CD8+ T Cells.
- International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations.
- Multiple innate immune pathways contribute to the immunogenicity of recombinant adenovirus vaccine vectors.
- Robust vaccine-elicited cellular immune responses in breast milk following systemic simian immunodeficiency virus DNA prime and live virus vector boost vaccination of ...
- Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys.
- TLR4 ligands augment antigen-specific CD8+ T lymphocyte responses elicited by a viral vaccine vector.
- Mucosal trafficking of vector-specific CD4+ T lymphocytes following vaccination of rhesus monkeys with adenovirus serotype 5.
- Novel adenovirus vector-based vaccines for HIV-1.
- Route of adenovirus-based HIV-1 vaccine delivery impacts the phenotype and trafficking of vaccine-elicited CD8+ T lymphocytes.
- Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus mon...
- Breadth of neutralizing antibodies elicited by stable, homogeneous clade A and clade C HIV-1 gp140 envelope trimers in guinea pigs.
- Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys.
- HIV-1 vaccine development after STEP.
- Protective efficacy of a single immunization of a chimeric adenovirus vector-based vaccine against simian immunodeficiency virus challenge in rhesus monkeys.
- Power to detect the effects of HIV vaccination in repeated low-dose challenge experiments.
- Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans.
- Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer.
- Trafficking of antigen-specific CD8+ T lymphocytes to mucosal surfaces following intramuscular vaccination.
- HIV vaccine trial canceled.
- A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys.
- Differential antigen requirements for protection against systemic and intranasal vaccinia virus challenges in mice.
- Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electr...
- Bovine adenovirus vectored vaccine for avian influenza.
- Magnitude and phenotype of cellular immune responses elicited by recombinant adenovirus vectors and heterologous prime-boost regimens in rhesus monkeys.
- Adenovirus serotype 5 hexon mediates liver gene transfer.
- HIV-1 vaccine candidate ineffective.
- Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D.
- HIV-1 vaccine development: progress and prospects.
- Immunogenicity of heterologous recombinant adenovirus prime-boost vaccine regimens is enhanced by circumventing vector cross-reactivity.
- Modulation of DNA vaccine-elicited CD8+ T-lymphocyte epitope immunodominance hierarchies.
- Age dependence of adenovirus-specific neutralizing antibody titers in individuals from sub-Saharan Africa.
- Immunogenicity of recombinant fiber-chimeric adenovirus serotype 35 vector-based vaccines in mice and rhesus monkeys.
- Use of molecular beacons for rapid, real-time, quantitative monitoring of cytotoxic T-lymphocyte epitope mutations in simian immunodeficiency virus.
- Immunogenicity of heterologous prime-boost regimens involving recombinant adenovirus serotype 11 (Ad11) and Ad35 vaccine vectors in the presence of anti-ad5 immunity.
- A human T-cell leukemia virus type 1 regulatory element enhances the immunogenicity of human immunodeficiency virus type 1 DNA vaccines in mice and nonhuman primates.
- Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein.
- Replication-defective adenovirus serotype 5 vectors elicit durable cellular and humoral immune responses in nonhuman primates.
- Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes.
- Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants.
- Adenovirus vector-based vaccines for human immunodeficiency virus type 1.
- Fitness costs limit viral escape from cytotoxic T lymphocytes at a structurally constrained epitope.
- Recruitment and expansion of dendritic cells in vivo potentiate the immunogenicity of plasmid DNA vaccines.
- Recombinant poxvirus boosting of DNA-primed rhesus monkeys augments peak but not memory T lymphocyte responses.
- Immunogenicity of recombinant adenovirus serotype 35 vaccine in the presence of pre-existing anti-Ad5 immunity.
- Neutralizing antibodies and CD8+ T lymphocytes both contribute to immunity to adenovirus serotype 5 vaccine vectors.
- Structural constraints on viral escape from HIV- and SIV-specific cytotoxic T-lymphocytes.
- Simian-human immunodeficiency virus escape from cytotoxic T-lymphocyte recognition at a structurally constrained epitope.
- SIV Infection-Mediated Changes in Gastrointestinal Bacterial Microbiome and Virome Are Associated with Immunodeficiency and Prevented by Vaccination.
Schools
Harvard Medical School
Massachusetts General Hospital
MghBrigham and Wpmen39s Hospital
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Blue Card PPO
- BlueConnect HMO
- Blue with Managed Care Behavioral Health HMO
- Preferred Blue PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- First Health (Coventry Health Care) PPO
- Choice Care PPO
- MultiPlan PPO
- PHCS Network PPO
- Tufts PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Education
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Massachusetts General Hospital -
Harvard Medical School
Hospital
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Brigham and Women's Hospital -
Beth Israel Deaconess Medical Center
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