Professor of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine; Director, Cardiac Anesthesia Division, Director, Integrated Vascular Biology Laboratory
Anesthesiology
Dr. Dan E. Berkowitz, MD
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Dan E. Berkowitz practices Anesthesiology. Berkowitz is also a published MD. He has 91 publication published. The most recent publication is: Endotoxin-induced alteration in the expression of leptin and beta3-adrenergic receptor in adipose tissue. He is registered with Medicare and accepts Medicare payments.
Publications
- 2,3-Diphosphoglycerate Concentrations in Autologous Salvaged Versus Stored Red Blood Cells and in Surgical Patients After Transfusion.
- Role of senescence marker p16(INK4a) measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adu...
- Seeking a blood pressure-independent measure of vascular properties.
- NEDDylation promotes endothelial dysfunction: A role for HDAC2.
- Soluble Guanylate Cyclase Is Required for Systemic Vasodilation But Not Positive Inotropy Induced by Nitroxyl in the Mouse.
- Melanopsin mediates light-dependent relaxation in blood vessels.
- Impaired Red Blood Cell Deformability after Transfusion of Stored Allogeneic Blood but Not Autologous Salvaged Blood in Cardiac Surgery Patients.
- Contribution of arginase activation to vascular dysfunction in cigarette smoking.
- New insights provided by a comparison of impaired deformability with erythrocyte oxidative stress for sickle cell disease.
- Increased tissue transglutaminase activity contributes to central vascular stiffness in eNOS knockout mice.
- Decreased erythrocyte deformability after transfusion and the effects of erythrocyte storage duration.
- A physiologic and biochemical profile of clinically rejected lungs on a normothermic ex vivo lung perfusion platform.
- Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age.
- Inhaled hydrogen sulfide improves graft function in an experimental model of lung transplantation.
- Hydrogen sulfide decreases reactive oxygen in a model of lung transplantation.
- Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve.
- Nitric oxide regulates tissue transglutaminase localization and function in the vasculature.
- Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels.
- Upregulation of Inducible Nitric Oxide Synthase Contributes to Attenuated Cutaneous Vasodilation in Essential Hypertensive Humans.
- Nitric oxide regulates non-classical secretion of tissue transglutaminase.
- HZE (56)Fe-Ion Irradiation Induces Endothelial Dysfunction in Rat Aorta: Role of Xanthine Oxidase.
- S-Nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase.
- Review article: implications of vascular aging.
- Restoring leptin signaling reduces hyperlipidemia and improves vascular stiffness induced by chronic intermittent hypoxia.
- Vascular stiffness and increased pulse pressure in the aging cardiovascular system.
- β2-adrenergic receptor-coupled phosphoinositide 3-kinase constrains cAMP-dependent increases in cardiac inotropy through phosphodiesterase 4 activation.
- Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries.
- Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases in vascular stiffness.
- Dietary inhibition of xanthine oxidase attenuates radiation-induced endothelial dysfunction in rat aorta.
- Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.
- Simulated microgravity-induced aortic remodeling.
- Sildenafil inhibits superoxide formation and prevents endothelial dysfunction in a mouse model of secondhand smoke induced erectile dysfunction.
- Increased oxidant activity mediates vascular dysfunction in vibration injury.
- Selective fluorescent labeling of S-nitrosothiols (S-FLOS): a novel method for studying S-nitrosation.
- Arginase and vascular aging.
- Perioperative blood pressure management: does central vascular stiffness matter?
- Endothelial arginase II: a novel target for the treatment of atherosclerosis.
- Mitochondrial arginase II constrains endothelial NOS-3 activity.
- Pulse pressure is an age-independent predictor of stroke development after cardiac surgery.
- Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction.
- Microgravity and cardiac atrophy: no sex discrimination.
- Microgravity-induced changes in aortic stiffness and their role in orthostatic intolerance.
- Myocyte nitroso-redox imbalance in sepsis: NO simple answer.
- Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness.
- Oxidized low-density lipoprotein-dependent endothelial arginase II activation contributes to impaired nitric oxide signaling.
- Response to Does Arginase Activity In Vitro Represent That In Vivo?
- Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism.
- Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity.
- Knockdown of arginase I restores NO signaling in the vasculature of old rats.
- Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity.
- Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice.
- Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling.
- Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction.
- Apurinic/apyrimidinic endonuclease 1 regulates endothelial NO production and vascular tone.
- Enhanced vasodilatory responses to milrinone in catecholamine-precontracted small pulmonary arteries.
- Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels.
- Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice.
- Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases.
- Estrogen has opposing effects on vascular reactivity in obese, insulin-resistant male Zucker rats.
- Impaired pulmonary artery contractile responses in a rat model of microgravity: role of nitric oxide.
- Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction.
- Sildenafil Citrate-Restored eNOS and PDE5 Regulation in Sickle Cell Mouse Penis Prevents Priapism Via Control of Oxidative/Nitrosative Stress.
- Localization of messenger RNA for three distinct alpha 2-adrenergic receptor subtypes in human tissues. Evidence for species heterogeneity and implications for human p...
- Endothelins. Biochemistry and pathophysiologic actions.
- Hypotension resistant to therapy with alpha receptor agonists complicating cardiopulmonary bypass: lithium as a potential cause.
- Weight loss is not associated with hyperleptinemia in humans with pancreatic cancer.
- Molecular biology in cardiovascular anesthesiology: the brave new frontier.
- Expression of alpha 1-adrenergic receptor subtype mRNA in rat tissues and human SK-N-MC neuronal cells: implications for alpha 1-adrenergic receptor subtype classifica...
- Constitutive nitric oxide synthase is expressed and nitric oxide-mediated relaxation is preserved in retrieved human aortocoronary vein grafts.
- Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age.
- Endothelial arginase II and atherosclerosis.
- Beta-3 adrenoceptor (beta-3AR) expression in leptin treated OB/OB mice.
- Effect of leptin deficiency on metabolic rate in ob/ob mice.
- P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction.
- Leptin repletion restores depressed {beta}-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy.
- Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway.
- Single exposure gamma-irradiation amplifies xanthine oxidase activity and induces endothelial dysfunction in rat aorta.
- Endogenous circulating sympatholytic factor in orthostatic intolerance.
- Phosphodiesterase-5A (PDE5A) is localized to the endothelial caveolae and modulates NOS3 activity.
- Single exposure to radiation produces early anti-angiogenic effects in mouse aorta.
- Leptin prevents respiratory depression in obesity.
- Hindlimb unweighting affects rat vascular capacitance function.
- Leptin is essential in maintaining normal vascular compliance independent of body weight.
- Endotoxin-induced alteration in the expression of leptin and beta3-adrenergic receptor in adipose tissue.
- Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.
- OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling.
- Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans.
- beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility.
- The effects of hindlimb unweighting on the capacitance of rat small mesenteric veins.
- Reduction of obesity, as induced by leptin, reverses endothelial dysfunction in obese (Lep(ob)) mice.
Schools
University Of The Witwatersrand Medical School
Long Island Jewish Mc
Duke University
Doctors Specialties
- Anesthesiology
Accepted Insurances
Education
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Duke University Hospital -
North Shore-Long Island Jewish Health System -
University of the Witwatersrand
Hospital
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Johns Hopkins Bayview Medical Center -
Johns Hopkins Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1689639585 |
| Last Name Of The Provider | BERKOWITZ |
| First Name Of The Provider | DAN |
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