Professor, Surgery, Vanderbilt University School of Medicine
Vascular Surgery
Dr. Colleen M. Brophy, MD
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Doctor Colleen M. Brophy, MD practices Vascular Surgery. She researched medicine at University of Utah School of Medicine. Colleen Brophy is a published doctor. She published 100 publications, including: 'The small heat shock-related protein-20 is an actin-associated protein.'
Publications
- Preoperative Predictors of 30-Day Mortality and Prolonged Length of Stay after Above-Knee Amputation.
- Race as a predictor of delay from diagnosis to endarterectomy in clinically significant Carotid stenosis.
- Brilliant Blue FCF as an Alternative Dye for Saphenous Vein Graft Marking: Effect on Conduit Function.
- Surgical vein graft preparation promotes cellular dysfunction, oxidative stress, and intimal hyperplasia in human saphenous vein.
- Pressure Control During Preparation of Saphenous Veins.
- Relaxin treatment reverses insulin resistance in mice fed a high-fat diet.
- Intimal thickness associated with endothelial dysfunction in human vein grafts.
- Role of cyclic nucleotide-dependent actin cytoskeletal dynamics: [ca(2+)]I and force suppression in forskolin-pretreated porcine coronary arteries.
- Action of abdominal muscles on rib cage in humans.
- Mining gene-Disease relationships from biomedical literature: weighting protein-protein interactions and connectivity measures.
- Disruption of proximal axillobifemoral bypass graft anastomosis.
- Activation of diacylglycerol in cultured endothelial cells exposed to cyclic strain.
- Focal segmental ischemia of the terminal ileum mimicking Crohn's Disease.
- Liver cell adenoma: diagnosis and treatment of a rare hepatic neoplastic process.
- Hydrocortisone rapidly induces aortic rupture in a genetically susceptible mouse.
- Characterization of an elastase from aneurysmal aorta which degrades intact aortic elastin.
- Angioscopy of arm vein infrainguinal bypass grafts.
- "Pseudoascites" secondary to an amylase-producing serous ovarian cystadenoma. A case study.
- Gastrointestinal Vascular and ischemic syndromes.
- Non-invasive impedance analysis: a new non-invasive test for graft surveillance.
- Decreased tissue inhibitor of metalloproteinases (TIMP) in abdominal aortic aneurysm tissue: a preliminary report.
- Exposure of endothelial cells to cyclic strain induces elevations of cytosolic Ca2+ concentration through mobilization of intracellular and extracellular pools.
- The role of inflammation in nonspecific abdominal aortic aneurysm Disease.
- Peripheral vascular bypass in juvenile-onset diabetes mellitus: are aggressive revascularization attempts justified?
- Angioscopically directed valvulotomy: a new valvulotome and technique.
- Persistent platelet activation by passivated grafts.
- Enhanced arterial contractile responses in diabetic hypercholesterolemic pig Carotid arteries.
- Expression and sequence of the gene for tissue inhibitor of metalloproteinases in patients with abdominal aortic aneurysms.
- Propranolol stimulates the crosslinking of matrix components in skin from the aneurysm-prone blotchy mouse.
- Recanalization of an occluded popliteal Artery following posterior knee dislocation.
- Defecation syncope secondary to functional inferior vena caval obstruction during a Valsalva maneuver.
- Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respi...
- Propranolol delays the formation of aneurysms in the male blotchy mouse.
- Phospholipase C: a putative mechanotransducer for endothelial cell response to acute hemodynamic changes.
- Tissue inhibitor of metalloproteases (TIMP) is matrix associated in aortic tissue: report of a radioimmunoassay.
- Age of onset, pattern of distribution, and histology of aneurysm development in a genetically predisposed mouse model.
- Thrombin contraction of Vascular smooth muscle: implications for vasospasm.
- Primary small bowel malignant tumors. Unrecognized until emergent laparotomy.
- The dynamic regulation of blood vessel caliber.
- Inadequate cerebral perfusion is an unlikely cause of perioperative stroke.
- The impact of balloon embolectomy on the function and morphology of the endothelium.
- Early experience with infectious complications of percutaneous femoral Artery closure devices.
- The paradox of smooth muscle physiology.
- Cyclic nucleotide-dependent vasorelaxation is associated with the phosphorylation of a small heat shock-related protein.
- Kinase activation and smooth muscle contraction in the presence and absence of calcium.
- Nitric oxide is an autocrine feedback inhibitor of Vascular smooth muscle contraction.
- Cyclosporine, but not FK506, selectively induces renal and coronary Artery smooth muscle contraction.
- Renal Artery smooth muscle is refractory to contraction by angiotensin II.
- Cellular mechanisms of cyclic nucleotide-induced vasorelaxation.
- Balloon angioplasty induces heat shock protein 70 in human blood vessels.
- Mitogen-activated protein kinase activation: an alternate signaling pathway for sustained Vascular smooth muscle contraction.
- Protein kinase C activation during Ca2+-independent Vascular smooth muscle contraction.
- Phosphorylation of HSP20 on serine 157.
- Vascular smooth muscle mechanics in isolated perfused segments of Carotid arteries.
- Impaired cyclic nucleotide-dependent vasorelaxation in human umbilical Artery smooth muscle.
- Localization, macromolecular associations, and function of the small heat shock-related protein HSP20 in rat heart.
- Stress causes decrease in Vascular relaxation linked with altered phosphorylation of heat shock proteins.
- The small heat shock-related protein, HSP20, is phosphorylated on serine 16 during cyclic nucleotide-dependent relaxation.
- Endothelial-dependent vasodilation is associated with increases in the phosphorylation of a small heat shock protein (HSP20).
- Cyclosporine-induced renal Artery smooth muscle contraction is associated with increases in the phosphorylation of specific contractile regulatory proteins.
- Heat shock protein expression in umbilical Artery smooth muscle.
- Phosphorylation of the small heat shock-related protein, HSP20, in Vascular smooth muscles is associated with changes in the macromolecular associations of HSP20.
- The small heat shock-related protein-20 is an actin-associated protein.
- Thrombin-induced vasospasm: cellular signaling mechanisms.
- Small heat shock proteins and vasospasm in human umbilical Artery smooth muscle.
- Functional expression of NOS 1 in Vascular smooth muscle.
- Phosphorylation events associated with cyclic nucleotide-dependent inhibition of smooth muscle contraction.
- Cellular stress inhibits Vascular smooth muscle relaxation.
- Thrombin activates MAPKAP2 kinase in Vascular smooth muscle.
- PI3-kinase/Akt modulates Vascular smooth muscle tone via cAMP signaling pathways.
- The macromolecular associations of heat shock protein-27 in Vascular smooth muscle.
- Detrimental effects of mechanical stretch on smooth muscle function in saphenous Veins.
- Women in academic surgery: the pipeline is busted.
- Inhibition of Mitogen Activated Protein Kinase Activated Protein Kinase II with MMI-0100 reduces intimal hyperplasia ex vivo and in vivo.
- Surgical skin markers impair human saphenous vein graft smooth muscle and endothelial function.
- A novel cell permeant peptide inhibitor of MAPKAP kinase II inhibits intimal hyperplasia in a human saphenous vein organ culture model.
- Transduction of biologically active motifs of the small heat shock-related protein HSP20 leads to relaxation of Vascular smooth muscle.
- Phosphorylation of the heat shock-related protein, HSP20, mediates cyclic nucleotide-dependent relaxation.
- Retroperitoneal repair of abdominal aortic aneurysms offers postoperative benefits to male patients in the Veterans Affairs Health System.
- Treatment with transducible phosphopeptide analogues of the small heat shock-related protein, HSP20, after experimental subarachnoid hemorrhage: prevention and reversa...
- Internalization and intracellular trafficking of a PTD-conjugated anti-fibrotic peptide, AZX100, in human dermal keloid fibroblasts.
- Design of a bioactive cell-penetrating peptide: when a transduction domain does more than transduce.
- The small heat shock protein, HSPB6, in muscle function and Disease.
- Gene expression and functional analyses of primary rat hepatocytes on nanofiber matrices.
- Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor.
- Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function.
- Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts.
- Enhanced skin penetration of P20 phosphopeptide using protein transduction domains.
- The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation.
- Heat shock protein expression in cerebral vessels after subarachnoid hemorrhage.
- cGMP-dependent protein kinase expression restores contractile function in cultured Vascular smooth muscle cells.
- Stress and vascular Disease at the cellular and molecular levels.
- Phosphorylation and activation of a transducible recombinant form of human HSP20 in Escherichia coli.
- Short-term, moderate dosage Vitamin E supplementation may have no effect on platelet aggregation, coagulation profile, and bleeding time in healthy individuals.
- Role of the small heat shock proteins in regulating Vascular smooth muscle tone.
- Comparative study of the skin penetration of protein transduction domains and a conjugated peptide.
- Transduction of phosphorylated heat shock-related protein 20, HSP20, prevents vasospasm of human umbilical Artery smooth muscle.
- Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics.
- Transducible recombinant small heat shock-related protein, HSP20, inhibits vasospasm and platelet aggregation.
Schools
University Of Utah School Of Medicine
Yale New Haven
Conditions Treated
- Carotid Artery Disease
- Peripheral Vascular Disease (PAD, PVD)
- Varicose Veins
Doctors Specialties
- Critical Care Surgery
- Vascular Surgery
Accepted Insurances
Education
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Beth Israel Deaconess Medical Center -
Yale-New Haven Hospital -
University of Utah School of Medicine
Hospital
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Vanderbilt Hospital and Clinics -
Williamson Medical Center
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