Associate Professor, Pediatrics, Children's Hospital, Harvard Medical School
Pediatric Hematology & Oncology
Dr. Colin Sieff, MD
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Colin Sieff works in the field of Pediatric Hematology & Oncology. He over the years received 1 awards: "Elected Member". Colin Sieff is a published physician as well. He has 97 publications published. The latest was: Phase I/II trial of PIXY321 (granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein) for treatment of inherited and acquired marrow failure synd...
Publications
- Altered translation of GATA1 in Diamond-Blackfan Anemia.
- Diagnosis and treatment of pediatric acquired aplastic Anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC).
- Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan Anemia.
- Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan an...
- Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan Anemia.
- Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan Anemia patients.
- Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan Anemia.
- Ribosomal protein S24 gene is mutated in Diamond-Blackfan Anemia.
- Defective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan Anemia.
- Investigation of a putative role for FLVCR, a cytoplasmic heme exporter, in Diamond-Blackfan Anemia.
- An RNA interference model of RPS19 deficiency in Diamond-Blackfan Anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexametha...
- Accumulation of an intron-retained mRNA for granulocyte macrophage-colony stimulating factor receptor common beta chain in neutrophils of myelodysplastic syndromes.
- Cellular Immune defects to Epstein-Barr virus-determined antigens in young males.
- Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative Diseases by clinical, virological, and immunopathol...
- Changes in Cell surface antigen expression during hemopoietic differentiation.
- Monoclonal antiglycophorin as a probe for erythroleukemias.
- Antigen expression on normal and leukaemic erythroid precursors.
- Acquired pure red-Cell aplasia associated with an increase of T Cells bearing receptors for the Fc of IgG.
- Pure red Cell aplasia.
- Comparative antigenic phenotypes of normal and leukemic hemopoietic precursor Cells analysed with a "library" of monoclonal antibodies.
- In vitro tests for distinguishing possible immune-mediated aplastic Anemia from transfusion-induced sensitization.
- The collection and evaluation of peripheral blood progenitor Cells sufficient for repetitive cycles of high-dose chemotherapy support.
- In vitro enhancement of erythropoiesis by steel factor in Diamond-Blackfan Anemia and treatment of other congenital cytopenias with recombinant interleukin 3/granulocy...
- Synergistic effects of interleukin-11 with other growth factors on the expansion of murine hematopoietic progenitors and maintenance of stem Cells in liquid culture.
- Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft-versus-host Disease and ex...
- Selective transgene expression for detection and elimination of contaminating carcinoma Cells in hematopoietic stem Cell sources.
- Preapheresis peripheral blood CD34+ mononuclear Cell counts as predictors of progenitor Cell yield.
- Subtyping analysis of Fanconi Anemia by immunoblotting and retroviral gene transfer.
- Phase I/II trial of PIXY321 (granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein) for treatment of inherited and acquired marrow failure synd...
- One-day ex vivo culture allows effective gene transfer into human nonobese diabetic/severe combined Immune-deficient repopulating cells using high-titer vesicular stom...
- Pure red-Cell aplasia.
- Essential role for the p55 tumor necrosis factor receptor in regulating hematopoiesis at a stem Cell level.
- Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP.
- Diamond-Blackfan Anemia.
- Maturation and lineage-specific expression of the coxsackie and adenovirus receptor in hematopoietic Cells.
- Congenital bone marrow failure syndromes.
- Evidence for linkage of familial Diamond-Blackfan Anemia to chromosome 8p23.3-p22 and for non-19q non-8p disease.
- The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor.
- Hematopoietic Cell proliferation and differentiation.
- Dye efflux studies suggest that hematopoietic stem Cells expressing low or undetectable levels of CD34 antigen exist in multiple species.
- Identification of distinct elements of the stromal microenvironment that control human hematopoietic stem/progenitor Cell growth and differentiation.
- The beta c component of the granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin 3 (IL-3)/IL-5 receptor interacts with a hybrid GM-CSF/erythropoietin ...
- Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor.
- A constitutively activated chimeric cytokine receptor confers factor-independent growth in hematopoietic Cell lines.
- Human granulocyte-macrophage colony-stimulating factor receptor signal transduction requires the proximal cytoplasmic domains of the alpha and beta subunits.
- A low-affinity human granulocyte-macrophage colony-stimulating factor/murine erythropoietin hybrid receptor functions in murine Cell lines.
- The production of steel factor mRNA in Diamond-Blackfan anaemia long-term cultures and interactions of steel factor with erythropoietin and interleukin-3.
- A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain.
- Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor.
- Clonality in juvenile chronic myelogenous leukemia.
- Expression and function of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit.
- [Regulation of hematopoiesis].
- The response of a child with primary sideroblastic Anemia to cyclophosphamide.
- Familial myelofibrosis.
- Monosomy 7 in childhood: a myeloproliferative disorder.
- Acute myeloid leukaemia in childhood: treatment in the United Kingdom.
- Purification of fetal hematopoietic progenitors and demonstration of recombinant multipotential colony-stimulating activity.
- Human recombinant granulocyte-macrophage colony-stimulating factor: a multilineage hematopoietin.
- Allogeneic bone-marrow transplantation in infantile malignant osteopetrosis.
- Isolation of a human stromal Cell strain secreting hemopoietic growth factors.
- Stromal Cell-associated erythropoiesis.
- Differential binding of erythroid and myeloid progenitors to fibroblasts and fibronectin.
- New hats for hematopoietic hormones.
- Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor Cell.
- Biology and clinical aspects of the hematopoietic growth factors.
- A phase I/II trial of recombinant granulocyte-macrophage colony-stimulating factor for children with aplastic Anemia.
- Interleukin-1, tumor necrosis factor, and the production of colony-stimulating factors by cultured mesenchymal Cells.
- Combinations of purified recombinant colony-stimulating factors are required for optimal hematopoietic differentiation.
- The sources and actions of the human colony stimulating factors.
- Hematopoiesis in vitro coexists with natural killer lymphocytes.
- Combinations of recombinant colony-stimulating factors are required for optimal hematopoietic differentiation in serum-deprived culture.
- Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-Cell tumor lines.
- Granulocyte-macrophage colony-stimulating factor and interleukin-3 mRNAs are produced by a small fraction of blood mononuclear Cells.
- Decreased hematopoietic accessory Cell function following bone marrow transplantation.
- Membrane antigen expression during hemopoietic differentiation.
- Hematopoietic growth factors.
- Human colony-stimulating factors and stromal Cell function.
- Human recombinant granulocyte-macrophage colony-stimulating factor increases Cell-to-Cell adhesion and surface expression of adhesion-promoting surface glycoproteins o...
- The biology of the colony stimulating factors.
- The biological activities and uses of recombinant granulocyte-macrophage and multi-colony stimulating factors.
- Interleukin 1 induces cultured human endothelial Cell production of granulocyte-macrophage colony-stimulating factor.
- Stimulation of human hematopoietic colony formation by recombinant gibbon multi-colony-stimulating factor or interleukin 3.
- The production of hematopoietic growth factors by endothelial accessory Cells.
- The role of endothelial Cells in hematopoiesis.
- Dependence of highly enriched human bone marrow progenitors on hemopoietic growth factors and their response to recombinant erythropoietin.
- RNA and protein evidence for haplo-insufficiency in Diamond-Blackfan anaemia patients with RPS19 mutations.
- Pathogenesis of the erythroid failure in Diamond Blackfan anaemia.
- Recent insights into the pathogenesis of Diamond-Blackfan anaemia.
- Genetic variants in the noncoding region of RPS19 gene in Diamond-Blackfan Anemia: potential implications for phenotypic heterogeneity.
- Gamma-interferon alters globin gene expression in neonatal and adult erythroid Cells.
- Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host Disease in patients with hematologic ...
- Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host Disease.
- Successful haploidentical mismatched bone marrow transplantation in severe combined immunodeficiency: T Cell removal using CAMPATH-I monoclonal antibody and E-rosetting.
- Selective expression of Cell surface antigens on human haemopoietic progenitor Cells.
- Expression of Cell-surface HLA-DR, HLA-ABC and glycophorin during erythroid differentiation.
- Mapping Cell surface antigen expression of haemopoietic progenitor Cells using monoclonal antibodies.
Conditions Treated
- Anemia
- Coagulation Disorders (incl. Hemophilia)
- Immune Thrombocytopenic Purpura (ITP)
- Neutropenia
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Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- Elected Member
Hospital
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Dana-Farber Cancer Institute
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