Professor, Diagnostic Radiology, Mayo Medical School
Radiology
Dr. Clifford R. Jack, MD
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Clifford Jack works in the field of Radiology. He researched medicine at Wayne State University School of Medicine. Wayne State University School of Medicine has a rank of 63 in research and a 85 in primary care Dr. Clifford R. Jack is a published physician. He has 99 publications published. The most current publication "Regional T1 relaxation time constants in Ex vivo human brain: Longitudinal effects of formalin exposure."
Publications
- Regional β-amyloid burden does not correlate with cognitive or language deficits in Alzheimer's disease presenting as aphasia.
- Cascading network failure across the Alzheimer's disease spectrum.
- Regional T1 relaxation time constants in Ex vivo human brain: Longitudinal effects of formalin exposure.
- Suspected non-Alzheimer disease pathophysiology - concept and controversy.
- Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia.
- Obesity, Insulin Resistance, and Incident Small Vessel Disease on Magnetic Resonance Imaging: Atherosclerosis Risk in Communities Study.
- Characterizing White Matter Tract Degeneration in Syndromic Variants of Alzheimer's Disease: A Diffusion Tensor Imaging Study.
- MRI-based brain atrophy rates in ADNI phase 2: acceleration and enrichment considerations for clinical trials.
- Association of Alzheimer's disease GWAS loci with MRI markers of brain aging.
- Protective variant for hippocampal atrophy identified by whole exome sequencing.
- Accelerated vs. unaccelerated serial MRI based TBM-SyN measurements for clinical trials in Alzheimer's disease.
- Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 β-Amyloid Measures Across the Spectrum of Alzheimer Disease.
- Age, Sex, and APOE ε4 Effects on Memory, Brain Structure, and β-Amyloid Across the Adult Life Span.
- Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly.
- Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer's disease spectrum.
- Working memory and language network dysfunctions in logopenic aphasia: a task-free fMRI comparison with Alzheimer's dementia.
- Clinical and neuroimaging biomarkers of amyloid-negative logopenic primary progressive aphasia.
- Predicting the risk of mild cognitive impairment in the Mayo Clinic Study of Aging.
- HarP: The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation. A standard of reference from a global working group.
- Brain amyloidosis ascertainment from cognitive, imaging, and peripheral blood protein measures.
- Amyloid-related imaging abnormalities-haemosiderin (ARIA-H) in patients with Alzheimer's disease treated with bapineuzumab: a historical, prospective secondary analysis.
- Brain atrophy over time in genetic and sporadic frontotemporal dementia: a study of 198 serial magnetic resonance images.
- Vascular imaging abnormalities and cognition: mediation by cortical volume in nondemented individuals: atherosclerosis risk in communities-neurocognitive study.
- Measuring the effects of aging and sex on regional brain stiffness with MR elastography in healthy older adults.
- Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies.
- Connectivity network measures predict volumetric atrophy in mild cognitive impairment.
- Does MRI scan acceleration affect power to track brain change?
- Diffusion weighted imaging-based maximum density path analysis and classification of Alzheimer's disease.
- Comparing 3T and 1.5T MRI for Mapping Hippocampal Atrophy in the Alzheimer's Disease Neuroimaging Initiative.
- The transitional association between β-amyloid pathology and regional brain atrophy.
- PART and SNAP.
- White matter integrity determined with diffusion tensor imaging in older adults without dementia: influence of amyloid load and neurodegeneration.
- Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging.
- FASTKD2 is associated with memory and hippocampal structure in older adults.
- The evolution of primary progressive apraxia of speech.
- Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50-89 years: a cross-sectional study.
- Functional connectivity in autosomal dominant and late-onset Alzheimer disease.
- Empowering imaging biomarkers of Alzheimer's disease.
- Seemingly unrelated regression empowers detection of network failure in dementia.
- Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment.
- Mapping ventricular expansion onto cortical gray matter in older adults.
- Coalition Against Major Diseases/European Medicines Agency biomarker qualification of hippocampal volume for enrichment of clinical trials in predementia stages of Alz...
- Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial.
- Serum cholesterol and variant in cholesterol-related gene CETP predict white matter microstructure.
- Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer's disease in veterans, using the Alzheimer's Disease Neuroimaging Initiative.
- APOE ε4 influences β-amyloid deposition in primary progressive aphasia and speech apraxia.
- TDP-43 in Alzheimer's disease is not associated with clinical FTLD or Parkinsonism.
- Emerging β-Amyloid Pathology and Accelerated Cortical Atrophy.
- Improved DTI registration allows voxel-based analysis that outperforms Tract-Based Spatial Statistics.
- Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment.
- TDP-43 is a key player in the clinical features associated with Alzheimer's disease.
- (18)F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons.
- Estimating long-term multivariate progression from short-term data.
- Diabetes and Elevated Hemoglobin A1c Levels Are Associated with Brain Hypometabolism but Not Amyloid Accumulation.
- Diffusion tensor imaging comparison of progressive supranuclear palsy and corticobasal syndromes.
- Treatment effects in a transgenic mouse model of Alzheimer's disease: a magnetic resonance spectroscopy study after passive immunization.
- Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias.
- The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.
- Regional proton magnetic resonance spectroscopy patterns in dementia with Lewy bodies.
- Progranulin-associated PiB-negative logopenic primary progressive aphasia.
- Amyloid burden correlates with cognitive decline in Alzheimer's disease presenting with aphasia.
- Biomarker modeling of Alzheimer's disease.
- Staging TDP-43 pathology in Alzheimer's disease.
- Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease.
- Operationalizing hippocampal volume as an enrichment biomarker for amnestic mild cognitive impairment trials: effect of algorithm, test-retest variability, and cut poi...
- Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults.
- Angular versus spatial resolution trade-offs for diffusion imaging under time constraints.
- Midbrain atrophy is not a biomarker of progressive supranuclear palsy pathology.
- Preclinical trials in autosomal dominant AD: Implementation of the DIAN-TU trial.
- The pattern of atrophy in familial Alzheimer disease: Volumetric MRI results from the DIAN study.
- Selective Worsening of Brain Injury Biomarker Abnormalities in Cognitively Normal Elderly Persons With β-Amyloidosis.
- The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception.
- Elevated occipital β-amyloid deposition is associated with widespread cognitive impairment in logopenic progressive aphasia.
- Impaired default network functional connectivity in autosomal dominant Alzheimer disease.
- MRS in Early and Presymptomatic Carriers of a Novel Octapeptide Repeat Insertion in the Prion Protein Gene.
- Identification of functional variants from whole-exome sequencing, combined with neuroimaging genetics.
- Imaging markers for Alzheimer disease: Which vs how.
- Breakdown of Brain Connectivity between Normal Aging and Alzheimer's Disease: A Structural k-Core Network Analysis.
- Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment.
- Microbleeds in the logopenic variant of primary progressive aphasia.
- Mapping creatinine- and cystatin C-related white matter brain deficits in the elderly.
- Neuroimaging comparison of primary progressive apraxia of speech and progressive supranuclear palsy.
- Modeling trajectories of regional volume loss in progressive supranuclear palsy.
- MR Imaging Features of Amyloid-Related Imaging Abnormalities.
- Identification of an atypical variant of logopenic progressive aphasia.
- Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.
- Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia.
- Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers.
- Unbiased tensor-based morphometry: improved robustness and sample size estimates for Alzheimer's disease clinical trials.
- The Effect of Subsyndromal Symptoms of Depression and White Matter Lesions on Disability for Individuals With Mild Cognitive Impairment.
- Corticospinal tract degeneration associated with TDP-43 type C pathology and semantic dementia.
- Frontal asymmetry in behavioral variant frontotemporal dementia: clinicoimaging and pathogenetic correlates.
- A commonly carried genetic variant in the delta opioid receptor gene, OPRD1, is associated with smaller regional brain volumes: Replication in elderly and young popula...
- APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
- Maximizing power to track Alzheimer's disease and MCI progression by LDA-based weighting of longitudinal ventricular surface features.
- Fat-mass-related hormone, plasma leptin, predicts brain volumes in the elderly.
- Focal hemosiderin deposits and ?-amyloid load in the ADNI cohort.
- A quantitative postmortem MRI design sensitive to white matter hyperintensity differences and their relationship with underlying pathology.
Schools
Wayne State University School Of Medicine
Henry Ford Hospital
Mayo Clinic Rochester
Doctors Specialties
- Neuroradiology
- Radiology
Accepted Insurances
Education
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Mayo School of Graduate Medical Education -
Henry Ford Hospital - Wayne State University -
Wayne State University School of Medicine
Hospital
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Mayo Clinic - Rochester, Minnesota
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