Professor of Medicine, Washington University St Louis
Endocrinology
Dr. Clay F. Semenkovich, MD
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Doctor Clay F. Semenkovich, MD is an expert in the field of Endocrinology. He studied medicine at Washington University School of Medicine in St. Louis. He received 4 awards: "America's Top Doctors", "CMS Meaningful Use Stage 1 Certification", "St. Louis Magazine: Top Doctors" and "Elected Member". Doctor Clay F. Semenkovich, MD is a published doctor and has 99 publications published. The lastest was: 'Low density lipoprotein receptor activity in homozygous familial hypercholesterolemia fibroblasts.' He accepts Medicare payments and is registered with Medicare.gov.
Publications
- Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function.
- Peroxisomal Lipid synthesis regulates inflammation by sustaining neutrophil membrane phosphoLipid composition and viability.
- A Calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.
- Structural Distinction of Diacyl-, Alkylacyl, and Alk-1-Enylacyl Glycerophosphocholines as [M - 15](-) Ions by Multiple-Stage Linear Ion-Trap Mass Spectrometry With El...
- Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling.
- Peroxisome Proliferator Activated Receptor-δ: The Middle Child Vies for Attention.
- Insulin-Regulated Protein Palmitoylation Impacts Endothelial Cell Function.
- Interleukins and atherosclerosis: a Dysfunctional family grows.
- Gut microbiota from twins discordant for obesity modulate Metabolism in mice.
- Nutrient-dependent phosphorylation channels Lipid synthesis to regulate PPAR?
- Fatty acid synthase and liver triglyceride Metabolism: Housekeeper or messenger?
- Genetic effects at pleiotropic Loci are context-dependent With consequences for the maintenance of genetic variation in populations.
- Fatty acid synthase modulates homeostatic responses to myocardial stress.
- Skeletal Muscle Lipid Flux: Running Water Carries No Poison.
- The importance of context to the genetic architecture of Diabetes-related traits is revealed in a genome-wide scan of a LG/J × SM/J murine model.
- Common sense treatment for common lipid Disorders.
- Endocrinology in 2011: new options for intractable problems.
- De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation.
- Diet-dependent genetic and genomic imprinting effects on Obesity in mice.
- Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter.
- Deletion of Tis7 protects mice from high-fat diet-induced weight gain and blunts the intestinal adaptive response postresection.
- Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum Lipids in a LG/JxSM/J murine model.
- Macrophage fatty-acid synthase deficiency decreases diet-induced atherosclerosis.
- p53 is required for chloroquine-induced atheroprotection but not insulin sensitization.
- Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic Abnormalities induced by a Western diet.
- Calpain-10 is a component of the Obesity-related quantitative trait locus Adip1.
- Identification of a physiologically relevant endogenous ligand for PPARalpha in liver.
- Calpain-10 is a component of the Obesity-related quantitative trait locus, Adip1.
- Inactivation of hypothalamic FAS protects mice from diet-induced Obesity and inflammation.
- Getting away from glucose: stop sugarcoating Diabetes.
- Why we should put clothes on mice.
- Decreased fetal size is associated With beta-cell hyperfunction in early life and failure With age.
- Altered hepatic triglyceride content after partial hepatectomy Without impaired liver regeneration in multiple murine genetic models.
- Insulin resistance and atherosclerosis.
- Requirement for p38 mitogen-activated protein kinase activity in neointima formation after vascular injury.
- Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking.
- Lysosomal Dysfunction results in altered energy balance.
- Respiratory uncoupling in skeletal muscle delays death and diminishes age-related Disease.
- Macrophage beta3 integrin suppresses Hyperlipidemia-induced inflammation by modulating TNFalpha expression.
- Absence of peroxisome proliferator-activated receptor-alpha abolishes hypertension and attenuates atherosclerosis in the Tsukuba hypertensive mouse.
- Retention of low-density lipoprotein in atherosclerotic lesions of the mouse: evidence for a role of lipoprotein lipase.
- Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
- Attenuated free cholesterol loading-induced apoptosis but preserved phosphoLipid composition of peritoneal macrophages from mice that do not express group VIA phosphol...
- Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis.
- Bone weighs in on Obesity.
- Grb2 is required for atherosclerotic lesion formation.
- The ABCs of beta-cell dysfunction in type 2 Diabetes.
- An afferent vagal nerve pathway links hepatic PPARalpha activation to glucocorticoid-induced insulin resistance and hypertension.
- Mechanisms underlying the resistance to diet-induced Obesity in germ-free mice.
- PPARalpha activation elevates blood pressure and does not correct glucocorticoid-induced insulin resistance in humans.
- ATM-dependent suppression of stress signaling reduces vascular disease in metabolic Syndrome.
- Fast predators or fast food, the fit still survive.
- PPARalpha: savior or savage?
- Targeted intestinal overexpression of the immediate early gene tis7 in transgenic mice increases triglyceride absorption and adiposity.
- TZDs and Diabetes: testing the waters.
- Maternal genotype affects adult offspring lipid, obesity, and Diabetes phenotypes in LGXSM recombinant inbred strains.
- Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J x SM/J murine model of Obesity.
- "New" hepatic fat activates PPARalpha to maintain glucose, Lipid, and cholesterol homeostasis.
- Alterations in thigh subcutaneous adipose tissue gene expression in protease inhibitor-based highly active antiretroviral therapy.
- PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, Abnormal weight control and hepatic steatosis.
- Pancreatic beta-cell lipoprotein lipase independently regulates islet glucose Metabolism and normal insulin secretion.
- A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related Diabetes.
- Quantitative trait loci for obesity- and Diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains.
- The gut microbiota as an environmental factor that regulates fat storage.
- Genetic evidence for discordance between obesity- and Diabetes-related traits in the LGXSM recombinant inbred mouse strains.
- UCP-mediated energy depletion in skeletal muscle increases glucose transport despite Lipid accumulation and mitochondrial dysfunction.
- Fatty acid Metabolism and vascular disease.
- Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association.
- Alpha2beta1 integrin and development of atherosclerosis in a mouse model: assessment of risk.
- Visceral adiposity, C-peptide levels, and low lipase activities predict HIV-dysLipidemia.
- Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity.
- Transgenic mice expressing lipoprotein lipase in adipose tissue. Absence of the proximal 3'-untranslated region causes translational upregulation.
- Dexamethasone induction of hypertension and Diabetes is PPAR-alpha dependent in LDL receptor-null mice.
- Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperLipidemic mice.
- Amino terminal 38.9% of apolipoprotein B-100 is sufficient to support cholesterol-rich lipoprotein production and atherosclerosis.
- Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities.
- PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells.
- Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice.
- Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. Octo...
- Fatty Acid Synthase Modulates Intestinal Barrier Function through Palmitoylation of Mucin 2.
- Short-term interruption of training affects both fasting and post-prandial lipoproteins.
- Cholesteryl ester storage Disease: complex molecular effects of chronic lovastatin therapy.
- A missense (Asp250----Asn) mutation in the lipoprotein lipase gene in two unrelated families With familial lipoprotein lipase deficiency.
- Structural and functional roles of highly conserved serines in human lipoprotein lipase. Evidence that serine 132 is essential for enzyme catalysis.
- A protein partially expressed on the surface of HepG2 cells that binds lipoproteins specifically is nucleolin.
- In vitro expression and site-specific mutagenesis of the cloned human lipoprotein lipase gene. Potential N-linked glycosylation site asparagine 43 is important for bot...
- Apolipoprotein B mRNA editing. Validation of a sensitive assay and developmental biology of RNA editing in the rat.
- Plasma lipids in patients with type I Diabetes mellitus. Influence of race, gender, and plasma glucose control: lipids do not correlate with glucose control in black w...
- Insulin regulation of lipoprotein lipase activity in 3T3-L1 adipocytes is mediated at posttranscriptional and posttranslational levels.
- Quantitative relationship between plasma lipids and glycohemoglobin in Type I patients. Longitudinal study of 212 patients.
- Lipoprotein lipase and hepatic lipase mRNA tissue specific expression, developmental regulation, and evolution.
- Estrogens induce low-density lipoprotein receptor activity and decrease intracellular cholesterol in human hepatoma cell line Hep G2.
- Induction of adenosine 3',5'-monophosphate-dependent protein kinase subunits during adipogenesis in vitro.
- Demonstration of functional low-density lipoprotein receptors by protein blotting in fibroblasts from a subject With homozygous receptor-negative familial hypercholest...
- The low density lipoprotein receptor on human peripheral blood monocytes and lymphocytes: visualization by ligand blotting and immunoblotting techniques.
- Diversity in expression of heterozygous familial hypercholesterolemia. Characterization of a unique kindred.
- Adverse effects due to morphine sulfate. Challenge to previous clinical doctrine.
- Low density lipoprotein receptor activity in homozygous familial hypercholesterolemia fibroblasts.
Schools
Washington Center School of Medicine
Barnes Jewish Hospital
Washington University
Conditions Treated
- Abnormal Thyroid
- Adrenal Insufficiency
- Calcium Metabolism Disorders
- Cushing's Syndrome
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Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- America's Top Doctors
- CMS Meaningful Use Stage 1 Certification
- St. Louis Magazine: Top Doctors
- Elected Member
Education
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Washington University - Barnes-Jewish Hospital -
Washington University School of Medicine in St. Louis
Hospital
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Barnes-Jewish Hospital
Drug Facts
| NPI NUMBER | 1548286867 | |
| NPPES Provider LastName | SEMENKOVICH | |
| NPPES Provider FirstName | CLAY | |
| NPPES Provider ZIPCode | 631101032 | |
| NPPES Provider State | MO | |
| Specialty Description | Endocrinology | |
| Total Claim Count | 414.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1548286867 |
| Last Name Of The Provider | SEMENKOVICH |
| First Name Of The Provider | CLAY |
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