Professor of Medicine, Beth Israel Deaconess Medical Center
Endocrinology
Dr. Christos S. Mantzoros, MD
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Christos S. Mantzoros, MD works in the field of Endocrinology. He studied medicine at Wayne State University School of Medicine. Wayne State University School of Medicine has a rank of 63 in research and a 85 in primary care He over the years received 4 awards: "Elected Member", "Fellow (FACP)", "Whos Who in Medicine and Healthcare" and "Fellow (FACE)". Christos Mantzoros is a published doctor as well. He has 101 publications published. The latest was: Differential effects of oral and intravenous lipid administration on key molecules related to energy homeostasis.
Publications
- Research advances in metabolism 2015.
- Early life adversity and/or posttraumatic stress disorder severity are associated with poor diet quality, including consumption of trans fatty acids, and fewer hours o...
- Cord blood irisin levels are positively correlated with birth weight in newborn infants.
- Exercising insulin sensitivity: AMPK turns on autophagy!
- New research developments and insights from Metabolism.
- Incretin therapy and Beta cell function.
- Posttraumatic stress disorder, alone or additively with early life adversity, is associated with obesity and cardiometabolic risk.
- From leptin to other adipokines in health and disease: facts and expectations at the beginning of the 21st century.
- Leptin in health and disease: facts and expectations at its twentieth anniversary.
- The role of leptin in regulating bone metabolism.
- 20 years of leptin: From the discovery of the leptin gene to leptin in our therapeutic armamentarium.
- Leptin and the brain: influences on brain development, cognitive functioning and psychiatric disorders.
- Leptin in nonalcoholic fatty liver disease: A narrative review.
- Lack of day/night variation in fibroblast growth factor 21 levels in young healthy men.
- Irisin in response to exercise in humans with and without metabolic syndrome.
- IGF1 and IGFBP3 in acute respiratory distress syndrome.
- New-Onset Diabetes and Statins: Throw the Bath Water Out, But, Please, Keep the Baby!
- Exercise-Induced Irisin Secretion Is Independent of Age or Fitness Level and Increased Irisin May Directly Modulate Muscle Metabolism Through AMPK Activation.
- The Effect of Leptin Replacement on Parathyroid Hormone, RANKL-Osteoprotegerin Axis, and Wnt Inhibitors in Young Women With Hypothalamic Amenorrhea.
- Alpha linolenic acid and oleic acid additively down-regulate malignant potential and positively cross-regulate AMPK/S6 axis in OE19 and OE33 esophageal cancer cells.
- 20 YEARS OF LEPTIN: Role of leptin in human reproductive disorders.
- Leptin therapy alters appetite and neural responses to food stimuli in brain areas of leptin sensitive subjects without altering brain structure.
- Attachment and the metabolic syndrome in midlife: the role of interview-based discourse patterns.
- Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk.
- Leptin: A hormone linking activation of neuroendocrine axes with neuropathology.
- Identification, and saturable nature, of signaling pathways induced by metreleptin in humans: comparative evaluation of in vivo, ex vivo and in vitro administration.
- Stress- and PTSD-associated obesity and metabolic dysfunction: A growing problem requiring further research and novel treatments.
- Leptin in congenital and HIV-associated lipodystrophy.
- Potential cardioprotective action of GLP-1: from bench to bedside.
- Can a Selective PPARγ Modulator Improve Glycemic Control in Patients With Type 2 Diabetes With Fewer Side Effects Compared With Pioglitazone?
- Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events.
- Omentin-1 levels are reduced by pharmacologic doses of leptin, but remain unaffected by energy deprivation and display no day-night variation.
- Irisin in response to acute and chronic whole-body vibration exercise in humans.
- Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans.
- Cohort Profile: Project Viva.
- Levels of circulating selenoprotein P, Fibroblast Growth Factor (FGF) 21, and FGF23 in relation to the metabolic syndrome in young children.
- Necessity for timely noninvasive diagnosis of nonalcoholic fatty liver disease.
- Diet quality is associated with circulating C-reactive protein but not irisin levels in humans.
- Irisin in patients with nonalcoholic fatty liver disease.
- Chemerin levels as predictor of acute coronary events: A case-control study nested within the veterans affairs normative aging study.
- Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans.
- Gender dimorphism and lack of day/night variation or effects of energy deprivation on undercarboxylated osteocalcin levels in humans.
- Advances in metabolism.
- Diet patterns, adipokines, and metabolism: Where are we and what is next?
- Detailed assessments of childhood adversity enhance prediction of central obesity independent of gender, race, adult psychosocial risk and health behaviors.
- Irisin in humans: recent advances and questions for future research.
- Cord blood levels of osteopontin as a phenotype marker of gestational age and neonatal morbidities.
- Relations of Plasma Total and High-Molecular-Weight Adiponectin to New-Onset Heart Failure in Adults â¥65 Years of Age (from the Cardiovascular Health Study).
- Regulation of cell proliferation and malignant potential by irisin in endometrial, colon, thyroid and esophageal cancer cell lines.
- Chemerin is expressed mainly in pancreas and liver, is regulated by energy deprivation, and lacks day/night variation in humans.
- Circulating Irisin in Relation to Insulin Resistance and the Metabolic Syndrome.
- Novel concepts in lipoprotein particle metabolism and regulation.
- Differential associations of leptin with adiposity across early childhood.
- GLP-1 promotes angiogenesis in human endothelial cells in a dose-dependent manner, through the Akt, Src and PKC pathways.
- Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cel...
- Adipokines in the HIV/HAART-associated lipodystrophy syndrome.
- Early growth and development of later life metabolic disorders.
- Amylin-induced downregulation of hippocampal neurogenesis is attenuated by leptin in a STAT3/AMPK/ERK-dependent manner in mice.
- Abdominal Obesity, Independent from Caloric Intake, Accounts for the Development of Intestinal Tumors in Apc1638N/+ Female Mice.
- Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals.
- Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: a meta-analysis using primary data of published studies.
- Associations of total and high-molecular-weight adiponectin with all-cause and cardiovascular mortality in older persons: the Cardiovascular Health Study.
- Fibroblast growth factor 21 levels in young healthy females display day and night variations and are increased in response to short-term energy deprivation through a l...
- Effects of trans fatty acids on glucose homeostasis: a meta-analysis of randomized, placebo-controlled clinical trials.
- FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to wei...
- Secretion patterns of circulating osteoprotegerin and response to acute and chronic energy deprivation in young healthy adults.
- Leptin as a modulator of neuroendocrine function in humans.
- Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice.
- The Role of Adiponectin in Cancer: A Review of Current Evidence.
- Selective PPAR? Modulator INT131 Normalizes Insulin Signaling Defects and Improves Bone Mass in Diet-Induced Obese Mice.
- Total and High-Molecular-Weight Adiponectin and Risk of Incident Diabetes in Older People.
- Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular inju...
- Variants of the Adiponectin and Adiponectin Receptor-1 Genes and Posttransplantation Diabetes Mellitus in Renal Allograft Recipients.
- The Emerging Role of Endocrine Disruptors in Pathogenesis of Insulin Resistance: A Concept Implicating Nonalcoholic Fatty Liver Disease.
- IGF1 and IGFBP3 in the Acute Respiratory Distress Syndrome.
- Direct role of adiponectin and adiponectin receptors in endometrial cancer: in vitro and ex vivo studies in humans.
- Insulin resistance in relation to melanoma risk.
- One year of changes for Metabolism, Clinical and Experimental: evolution and intelligent design at work.
- Circulating Adiponectin Is Inversely Associated with Risk of Thyroid Cancer: In Vivo and in Vitro Studies.
- Short-Term Energy Deprivation Alters Activin A and Follistatin But Not Inhibin B Levels of Lean Healthy Women in a Leptin-Independent Manner.
- Circulating clusterin (apolipoprotein J) levels do not have any day/night variability and are positively associated with total and LDL cholesterol levels in young heal...
- Circulating Lipocalin-2 is associated with body fat distribution at baseline, but is not an independent predictor of insulin resistance: the prospective Cyprus Metabol...
- Energy deprivation alters in a leptin- and cortisol-independent manner circulating levels of activin A and follistatin but not myostatin in healthy males.
- The quest for the perfect biomarker of long-term glycemia: new studies, new trials and tribulations.
- Preadipocyte factor-1 levels are higher in women with hypothalamic amenorrhea and are associated with bone mineral content and bone mineral density through a mechanism...
- Dietary walnuts inhibit colorectal cancer growth in mice by suppressing angiogenesis.
- Leptin in human physiology and pathophysiology.
- Drug-drug interactions in HIV medicine: a not so simple and straightforward road to the future.
- Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women.
- Body fat redistribution and metabolic abnormalities in HIV-infected patients on highly active antiretroviral therapy: novel insights into pathophysiology and emerging ...
- Efficacy of metreleptin in obese patients with type 2 diabetes: cellular and molecular pathways underlying leptin tolerance.
- Clusterin (apolipoprotein J): wither link with diabetes and cardiometabolic risk?
- Effects of leptin and adiponectin on pancreatic β-cell function.
- Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study.
- Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer.
- Leptin administration to overweight and obese subjects for six months increases free leptin concentrations but does not alter circulating hormones of the thyroid and I...
- Brain responses to food images during the early and late follicular phase of the menstrual cycle in healthy young women: relation to fasting and feeding.
- Leptin treatment reduces body fat but does not affect lean body mass or the myostatin-follistatin-activin axis in lean hypoleptinemic women.
- Differential effects of oral and intravenous lipid administration on key molecules related to energy homeostasis.
- GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desir...
Schools
University of Athens College of Medicine School of Health Science National amp Kapodistrian
Wayne State University
Harvard Med School
Conditions Treated
- Hyperlipidemia
- Hyperparathyroidism
- Osteoporosis
Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- Elected Member
- Fellow (FACP)
- Whos Who in Medicine and Healthcare
- Fellow (FACE)
Education
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Wayne State University School of Medicine -
University of Athens
Hospital
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Beth Israel Deaconess Medical Center
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