Physician
Internal Medicine
Dr. Christopher L. Karp, MD
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Dr. Christopher L. Karp is an expert in the field of Internal Medicine. He received awards:"Elected Member". Christopher Karp is a published physician. He has 93 publications published. The most current publication "Interleukin-13: central mediator of allergic asthma."
Publications
- Cnr2 deficiency confers resistance to inflammation-induced preterm birth in mice.
- The aryl hydrocarbon receptor promotes IL-10 production by NK cells.
- ATF3 is a novel regulator of mouse neutrophil migration.
- Foxa3 Induces Goblet Cell Metaplasia and Inhibits Innate Antiviral Immunity.
- Contributions of the Three CYP1 Monooxygenases to Pro-Inflammatory and Inflammation-Resolution Lipid Mediator Pathways.
- The TLR4 antagonist Eritoran protects mice from lethal influenza infection.
- Blockade of chronic type I interferon signaling to control persistent LCMV infection.
- Tracking antigen-specific CD4(+) T cells throughout the course of chronic Leishmania major infection in resistant mice.
- Interferon-? Therapy Prolongs Survival in Rhesus Macaque Models of Ebola and Marburg Hemorrhagic Fever.
- Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation.
- Unstressing intemperate models: how cold stress undermines mouse modeling.
- Cutting Edge: Regulation of TLR4-Driven B Cell Proliferation by RP105 Is Not B Cell Autonomous.
- Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection.
- Therapeutic enhancement of protective immunity during experimental leishmaniasis.
- Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio,...
- Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis.
- Guilt by intimate association: what makes an allergen an allergen?
- Lipopolysaccharide exposure is linked to activation of the acute phase response and growth failure in pediatric Crohn's disease and murine colitis.
- New insights into innate immune mechanisms underlying allergenicity.
- Mice with a selective impairment of IFN-gamma signaling in macrophage lineage cells demonstrate the critical role of IFN-gamma-activated macrophages for the control of...
- Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells.
- Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis.
- Nonredundant roles for B cell-derived IL-10 in immune counter-regulation.
- Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiati...
- Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease.
- Getting to the core of the gut microbiome.
- Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10.
- Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein.
- Endogenous functions of the aryl hydrocarbon receptor (AHR): intersection of cytochrome P450 1 (CYP1)-metabolized eicosanoids and AHR biology.
- Immune activation and IL-12 production during acute/early HIV infection in the absence and presence of highly active, antiretroviral therapy.
- Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse.
- Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6.
- Proapoptotic Bcl-2 family member Bim promotes persistent infection and limits protective immunity.
- Coinfection with HIV and tropical infectious diseases. II. Helminthic, fungal, bacterial, and viral pathogens.
- Coinfection with HIV and tropical infectious diseases. I. Protozoal pathogens.
- Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105.
- Modulation of the IL-12/IFN-gamma axis by IFN-alpha therapy for hepatitis C.
- An adenoviral vector for probing promoter activity in primary immune cells.
- Inhibition of TLR-4/MD-2 signaling by RP105/MD-1.
- Association of CTLA4 polymorphism with regulatory T cell frequency.
- Cystic fibrosis and lipoxins.
- An oily, sustained counter-regulatory response to TB.
- Flt3 ligand treatment reverses endotoxin tolerance-related immunoparalysis.
- Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.
- Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection.
- Chitin checking--novel insights into asthma.
- Biomedicine. Eosinophils in asthma: remodeling a tangled tale.
- The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma.
- Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway.
- Interferon-beta 1a and SARS coronavirus replication.
- C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism.
- I-Tim-izing the pathways of counter-regulation.
- Human immunodeficiency virus-1 RNA levels and CD4 lymphocyte counts, during treatment for active tuberculosis, in South African patients.
- A role for immune complexes in enhanced respiratory syncytial virus disease.
- Cryptosporidiosis stimulates an inflammatory intestinal response in malnourished Haitian children.
- Immune response to engineered tissues and cells: breakout session summary.
- Immunological barriers (opportunities?) to the use of bioengineered tissue: taking note of the innate immune system.
- Immunological concerns with bioengineering approaches.
- Interferon-beta therapy for multiple sclerosis induces reciprocal changes in interleukin-12 and interleukin-10 production.
- A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity.
- The germless theory of allergic disease: revisiting the hygiene hypothesis.
- Natural measles causes prolonged suppression of interleukin-12 production.
- Type I interferons and IL-12: convergence and cross-regulation among mediators of cellular immunity.
- IL-12 suppression during experimental endotoxin tolerance: dendritic cell loss and macrophage hyporesponsiveness.
- Interferon-beta in multiple sclerosis: altering the balance of interleukin-12 and interleukin-10?
- Complement and IL-12: yin and yang.
- Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma.
- Mitogenesis in glioblastoma multiforme cell lines: a role for NGF and its TrkA receptors.
- Interferon beta in multiple sclerosis: is IL-12 suppression the key?
- Receptor mediated subversion of macrophage cytokine production by intracellular pathogens.
- Interleukin-12: amiss in MS.
- Tropical infectious diseases in human immunodeficiency virus-infected patients.
- Measles: immunosuppression, interleukin-12, and complement receptors.
- Paecilomyces lilacinus fungemia in an adult bone marrow transplant recipient.
- Interleukin-13: central mediator of allergic asthma.
- The effect of acute infectious illnesses on plasma human immunodeficiency virus (HIV) type 1 load and the expression of serologic markers of immune activation among HI...
- Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance.
- Mapping of specific and promiscuous HLA-DR-restricted T-cell epitopes on the Plasmodium falciparum 27-kilodalton sexual stage-specific antigen.
- Modulation of cell death by Bcl-XL through caspase interaction.
- Leptin regulates proinflammatory immune responses.
- Inhibition of IL-12 production by thalidomide.
- Inhibition of human interleukin-12 production by pentoxifylline.
- Kupffer cell depletion abolishes induction of interleukin-10 and permits sustained overexpression of tumor necrosis factor alpha messenger RNA in the regenerating rat ...
- Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice.
- Mechanism of suppression of cell-mediated immunity by measles virus.
- Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis.
- Kupffer cell depletion by gadolinium chloride enhances liver regeneration after partial hepatectomy in rats.
- Conjunctival intraepithelial neoplasia. A possible marker for human immunodeficiency virus infection?
- T-cell responses to infected autologous monocytes in patients with cutaneous and mucocutaneous leishmaniasis.
- In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma.
- Lipophosphoglycan masks recognition of the Leishmania donovani promastigote surface by human kala-azar serum.
- Differential colonization with segmented filamentous bacteria and Lactobacillus murinus do not drive divergent development of diet-induced obesity in C57BL/6 mice.
Schools
University of North Carolina At Chapel Hill
Ri Hospital Brown University
Georgetown University Hospital
Johns Hopkins
Niaid
Doctors Specialties
- Infectious Disease Medicine
- Internal Medicine
Accepted Insurances
- Cofinity PPO
Awards
- Elected Member
Education
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Georgetown University Hospital -
Brown University
Hospital
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Cincinnati Children's Hospital Medical Center
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