Physician

Family Medicine

Doctor Christopher J. Brouillette, MD is an expert in the field of Family Medicine. He over the years received 2 awards: "Diabetes Recognition Program" and "CMS Meaningful Use Stage 1 Certification". Doctor Christopher J. Brouillette, MD is a published doctor and has 47 publications published. The lastest was: 'The lipid-free structure of apolipoprotein A-I: effects of amino-terminal deletions.'

Publications

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• Plasma concentrations of apolipoprotein B are modulated by a gene--diet interaction effect between the LFABP T94A polymorphism and dietary fat intake in French-Canadia...
• The amphipathic alpha helix: a multifunctional structural motif in plasma apolipoproteins.
• The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function.
• Intracellular transport and virion incorporation of vpx requires interaction with other virus type-specific components.
• Lipolytic surface remnants of triglyceride-rich lipoproteins are cytotoxic to macrophages but not in the presence of high density lipoprotein. A possible mechanism of ...
• Thermal stabilities of mutant Escherichia coli tryptophan synthase alpha subunits.
• Amphipathic helix motif: classes and properties.
• Structural models of human apolipoprotein A-I.
• Structure and thermal stability of monomeric bacteriorhodopsin in mixed phospholipid/detergent micelles.
• Down-regulation of cell surface receptors is modulated by polar residues within the transmembrane domain.
• The structure of human lipoprotein A-I. Evidence for the "belt" model.
• Use of synthetic peptide analogues to localize lecithin:cholesterol acyltransferase activating domain in apolipoprotein A-I.
• Stereoselective binding of an enantiomeric pair of stromelysin-1 inhibitors caused by conformational entropy factors.
• Role of amphipathic helixes in HDL structure/function.
• Interdomain communication of T-cell CD4 studied by absorbance and fluorescence difference spectroscopy measurements of urea-induced unfolding.
• Analysis of the binding of hydroxamic acid and carboxylic acid inhibitors to the stromelysin-1 (matrix metalloproteinase-3) catalytic domain by isothermal titration ca...
• Kinetic and calorimetric evidence for two distinct scaffolding protein binding populations within the bacteriophage P22 procapsid.
• Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation.
• Structural models of human apolipoprotein A-I: a critical analysis and review.
• Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding.
• Analysis of the two-state behavior of the thermal unfolding serum retinol binding protein containing a single retinol ligand.
• Crystallization of truncated human apolipoprotein A-I in a novel conformation.
• Human apolipoprotein A-I: structure determination and analysis of unusual diffraction characteristics.
• Structural analysis of apolipoprotein A-I: effects of amino- and carboxy-terminal deletions on the lipid-free structure.
• Truncation of the amino terminus of human apolipoprotein A-I substantially alters only the lipid-free conformation.
• Structural analysis of apolipoprotein A-I: limited proteolysis of methionine-reduced and -oxidized lipid-free and lipid-bound human apo A-I.
• The lipid-free structure of apolipoprotein A-I: effects of amino-terminal deletions.
• Stabilization of active-site loops in NH3-dependent NAD+ synthetase from Bacillus subtilis.
• NH3-dependent NAD+ synthetase from Bacillus subtilis at 1 A resolution.
• His-tag impact on structure.
• A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris.
• Integrated biophysical studies implicate partial unfolding of NBD1 of CFTR in the molecular pathogenesis of F508del cystic fibrosis.
• Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide-binding domain 1.
• Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
• SAR studies for a new class of antibacterial NAD biosynthesis inhibitors.
• Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs).
• Structure of nicotinic acid mononucleotide adenylyltransferase from Bacillus anthracis.
• Structural adaptation of an interacting non-native C-terminal helical extension revealed in the crystal structure of NAD+ synthetase from Bacillus anthracis.
• Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups.
• Förster resonance energy transfer measurements are consistent with a helical bundle model for lipid-free apolipoprotein A-I.
• Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library.
• Engineering mouse apolipoprotein A-I into a monomeric, active protein useful for structural determination.
• Role of inhibitor aliphatic chain in the thermodynamics of inhibitor binding to Escherichia coli enoyl-ACP reductase and the Phe203Leu mutant: a proposed mechanism for...
• Dimethyl sulfoxide at 2.5% (v/v) alters the structural cooperativity and unfolding mechanism of dimeric bacterial NAD+ synthetase.
• Deletion of DnaK's lid strengthens binding to the nucleotide exchange factor, GrpE: a kinetic and thermodynamic analysis.
• Tethered dimers as NAD synthetase inhibitors with antibacterial activity.

Schools

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• Univ Of Fl Coll Of Med

• Florida Hospital Med Center

• Orlando Reg Healthcare Sys

Doctors Specialties

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• Family Medicine

Accepted Insurances

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• Aetna HMO
• Choice Plus POS II
• Assurant Health
• AvMed
• Bakery & Confectionary Union Plan
• Blue Card PPO
• Blue Care HMO
• Blue Select
• BlueDental Choice
• NetworkBlue
• Cigna HMO
• Cigna PPO
• Great West Healthcare-Cigna PPO
• LocalPlus
• Open Access Plus
• CoreSource
• Coventry Health Care
• Employer Group PPO
• First Health (Coventry Health Care) PPO
• GEHA
• Choice Care PPO
• Preferred PPO
• Select HMO
• Medical Mutual of Ohio
• Medicare MCR
• MultiPlan PPO
• Principal Life
• Choice Plus POS
• Navigate HMO
• Navigate POS
• Neighborhood Health Partnership
• Options PPO
• United Healthcare

Awards

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• Diabetes Recognition Program
• CMS Meaningful Use Stage 1 Certification

Education

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• Orlando Health

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