Physician

Oncology

Dr. Christopher A. Klebanoff, MD

Christopher Klebanoff practices Oncology. Christopher Klebanoff has written publications. He has 29 publications published with PubMed. The lastest paper is: 'Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance.'

Publications

Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance.
Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.
Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest.
Immunotherapy: Treatment of aggressive lymphomas with anti-CD19 CAR T cells.
Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells.
BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.
Paths to stemness: building the ultimate antitumour T cell.
Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature.
Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice.
Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies.
Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.
Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells.
Pharmacologic induction of CD8+ T cell memory: better living through chemistry.
Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination.
Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity.
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy.
Interleukin-2-dependent mechanisms of tolerance and immunity in vivo.
Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells.
Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells.
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells.
CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.
Vaccine-stimulated, adoptively transferred CD8+ T cells traffic indiscriminately and ubiquitously while mediating specific tumor destruction.
Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer.
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells.
Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.
Therapeutic cancer vaccines: are we there yet?
CD8+ T-cell memory in tumor immunology and immunotherapy.
Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy.

Schools

Emory University

Doctors Specialties

Medical Oncology
Oncology

Accepted Insurances

Education

National Institutes of Health Clinical Center
Johns Hopkins University

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