Assistant Professor, Emergency Medicine, Yale University School of Medicine
Emergency Medicine
Dr. Charles R. Wira III, MD
Dr. Charles R. Wira III works in the field of Emergency Medicine. He graduated from Geisel School of Medicine at Dartmouth. Geisel School of Medicine at Dartmouth is ranked 37/29 in Research/PrimaryCare. Charles R. Wira III, MD is also published. He has 68 publications published. The lastest publication: "Risk rtPA: An iOS mobile application based on TURN for predicting 90-day outcome after IV thrombolysis.' He is registered with Medicare and accepts Medicare payments.
Publications
- Missed Ischemic Stroke Diagnosis in the Emergency Department by Emergency Medicine and Neurology Services.
- On- versus Off-Hour Patient Cohorts at a Primary Stroke Center: Onset-to-Treatment Duration and Clinical Outcomes after IV Thrombolysis.
- Risk rtPA: An iOS mobile application based on TURN for predicting 90-day outcome after IV thrombolysis.
- The role of sex hormones in immune protection of the female reproductive tract.
- Cohort-Based Identification of Predictors of Symptomatic Intracerebral Hemorrhage After IV Thrombolysis.
- Modest Association between the Discharge Modified Rankin Scale Score and Symptomatic Intracerebral Hemorrhage after Intravenous Thrombolysis.
- Early Identification and Management of Patients with Severe Sepsis and Septic Shock in the Emergency Department.
- Effects of Tenofovir on Cytokines and Nucleotidases in HIV-1 Target Cells and the Mucosal Tissue Environment in the Female Reproductive Tract.
- Comparison of 8 Scores for predicting Symptomatic Intracerebral Hemorrhage after IV Thrombolysis.
- Innate Immunity in the Vagina (Part II): Anti-HIV Activity and Antiviral Content of Human Vaginal Secretions.
- Estradiol Regulation of Constitutive and Keratinocyte Growth Factor-Induced CCL20 and CXCL1 Secretion by Mouse Uterine Epithelial Cells.
- Phenotype and susceptibility to HIV infection of CD4(+) Th17 cells in the human female reproductive tract.
- Regulation of Mucosal Immunity in the Female Reproductive Tract: The Role of Sex Hormones in Immune Protection Against Sexually Transmitted Pathogens.
- The Role of Sex Hormones and the Tissue Environment in Immune Protection Against HIV in the Female Reproductive Tract.
- Meta-analysis of Protocolized Goal-Directed Hemodynamic Optimization for the Management of Severe Sepsis and Septic Shock in the Emergency Department.
- The shock index as a predictor of vasopressor use in emergency department patients with severe sepsis.
- The immune system in menopause: Pros and cons of hormone therapy.
- A multiplexed assay to detect antimicrobial peptides in biological fluids and cell secretions.
- Innate and adaptive anti-HIV immune responses in the female reproductive tract.
- Innate Immunity in the Vagina (Part I): Estradiol Inhibits HBD2 and Elafin Secretion by Human Vaginal Epithelial Cells.
- Immunobiology of Genital Tract Trauma: Endocrine Regulation of HIV Acquisition in Women Following Sexual Assault or Genital Tract Mutilation.
- Estrogen receptor ? antagonists mediate changes in CCL20 and CXCL1 secretions in the murine female reproductive tract.
- Pathogen recognition in the human female reproductive tract: expression of intracellular cytosolic sensors NOD1, NOD2, RIG-1, and MDA5 and response to HIV-1 and Neisse...
- Cardiac complications in acute ischemic stroke.
- Effect of Estradiol and Pathogen Associated Molecular Patterns (PAMP) on Class II-Mediated Antigen Presentation and Immunomodulatory Molecule Expression in the Mouse F...
- Modulation of Hepatocyte Growth Factor Secretion in Human Female Reproductive Tract Stromal Fibroblasts by Poly (I:C) and Estradiol.
- The impact of cardiac contractility on cerebral blood flow in ischemia.
- 2010 Workshop: Mucosal immunity in the male and female reproductive tract and prevention of HIV transmission.
- Human uterine epithelial cell secretions regulate dendritic cell differentiation and responses to TLR ligands.
- Anti-HIV activity in cervical-vaginal secretions from HIV-positive and -negative women correlate with innate antimicrobial levels and IgG antibodies.
- Uterine epithelial cell regulation of DC-SIGN expression inhibits transmitted/founder HIV-1 trans infection by immature dendritic cells.
- Human uterine natural killer cells but not blood natural killer cells inhibit human immunodeficiency virus type 1 infection by secretion of CXCL12.
- Severe angioedema in myxedema coma: a difficult airway in a rare endocrine emergency.
- Estradiol modulation of hepatocyte growth factor by stromal fibroblasts in the female reproductive tract.
- Surviving sepsis in low-income and middle-income countries: new directions for care and research.
- Vascular endothelial growth factor C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface.
- Estradiol regulates expression of estrogen receptor ERalpha46 in human macrophages.
- Estradiol regulates MICA expression in human endometrial cells.
- Antiviral responses of human Fallopian tube epithelial cells to toll-like receptor 3 agonist poly(I:C).
- Innate Immunity in the Female Reproductive Tract: Role of Sex Hormones in Regulating Uterine Epithelial Cell Protection Against Pathogens.
- Estradiol attenuates lipopolysaccharide-induced CXC chemokine ligand 8 production by human peripheral blood monocytes.
- Unique characteristics of NK cells throughout the human female reproductive tract.
- Expression of Toll-like receptors (TLR) and responsiveness to TLR agonists by polarized mouse uterine epithelial cells in culture.
- Lipopolysaccharide-induced IL-1 beta production by human uterine macrophages up-regulates uterine epithelial cell expression of human beta-defensin 2.
- TLRs mediate IFN-gamma production by human uterine NK cells in endometrium.
- IL-1beta-mediated proinflammatory responses are inhibited by estradiol via down-regulation of IL-1 receptor type I in uterine epithelial cells.
- Polarized uterine epithelial cells preferentially present antigen at the basolateral surface: role of stromal cells in regulating class II-mediated epithelial cell ant...
- Effects of estradiol on lipopolysaccharide and Pam3Cys stimulation of CCL20/macrophage inflammatory protein 3 alpha and tumor necrosis factor alpha production by uteri...
- Secretion of monocyte chemotactic protein-1 by human uterine epithelium directs monocyte migration in culture.
- Hepatocyte growth factor regulation of uterine epithelial cell transepithelial resistance and tumor necrosis factor alpha release in culture.
- HIV-1 infection of the female reproductive tract.
- Innate immunity in the human female reproductive tract: antiviral response of uterine epithelial cells to the TLR3 agonist poly(I:C).
- CCL20/macrophage inflammatory protein 3alpha and tumor necrosis factor alpha production by primary uterine epithelial cells in response to treatment with lipopolysacch...
- Recruitment of uterine NK cells: induction of CXC chemokine ligands 10 and 11 in human endometrium by estradiol and progesterone.
- Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tract.
- Unique phenotype of human uterine NK cells and their regulation by endogenous TGF-beta.
- Transmission of HIV-1 by primary human uterine epithelial cells and stromal fibroblasts.
- Synergy between IL-8 and GM-CSF in reproductive tract epithelial cell secretions promotes enhanced neutrophil chemotaxis.
- Effect of Escherichia coli and Lactobacillus rhamnosus on macrophage inflammatory protein 3 alpha, tumor necrosis factor alpha, and transforming growth factor beta rel...
- Effect of mouse uterine stromal cells on epithelial cell transepithelial resistance (TER) and TNFalpha and TGFbeta release in culture.
- Human immunodeficiency virus type 1 infection of human uterine epithelial cells: viral shedding and cell contact-mediated infectivity.
- Antigen presentation by vaginal cells: role of TGFbeta as a mediator of estradiol inhibition of antigen presentation.
- Effect of menstrual status on antibacterial activity and secretory leukocyte protease inhibitor production by human uterine epithelial cells in culture.
- Sex hormones regulate tenofovir-diphosphate in female reproductive tract cells in culture.
- Effect of Tenofovir on Nucleotidases and Cytokines in HIV-1 Target Cells.
- Estradiol regulation of nucleotidases in female reproductive tract epithelial cells and fibroblasts.
- Estradiol Reduces Susceptibility of CD4(+) T Cells and Macrophages to HIV-Infection.
Schools
Dartmouth Medical School
Doctors Specialties
- Emergency Medicine
- Internal Medicine
Accepted Insurances
Education
-
Henry Ford Hospital - Wayne State University -
Geisel School of Medicine at Dartmouth
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