Assistant Professor, Medicine, Emory University School of Medicine
Cardiology
Dr. Charles D. Searles, MD
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Dr. Charles D. Searles is an expert in the field of Cardiology. He attended Georgetown University School of Medicine. Georgetown University School of Medicine is ranked 49/84 in Research/PrimaryCare. Charles Searles has written publications. He has 30 publications published with PubMed. The lastest publication is: 'The identification and characterization of a GABAergic system in the cholinergic neuroblastoma x glioma hybrid clone NG108-15.'
Publications
- Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology.
- TNF-α alters the release and transfer of microparticle-encapsulated miRNAs from endothelial cells.
- Shear sensitive microRNAs and atherosclerosis.
- MiRNA-155 targets myosin light chain kinase and modulates actin cytoskeleton organization in endothelial cells.
- miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export.
- Coronary heart disease alters intercellular communication by modifying microparticle-mediated microRNA transport.
- Using information theory to assess the communicative capacity of circulating microRNA.
- miR181a protects against angiotensin II-induced osteopontin expression in vascular smooth muscle cells.
- Intracellular and Extracellular miRNAs in Regulation of Angiogenesis Signaling.
- In vitro quantification of specific microRNA using molecular beacons.
- MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity.
- Laminar shear stress modulates phosphorylation and localization of RNA polymerase II on the endothelial nitric oxide synthase gene.
- Nebivolol in high-risk, obese African Americans with stage 1 Hypertension: effects on blood pressure, vascular compliance, and endothelial function.
- Molecular beacons can assess changes in expression and 3'-polyadenylation of human eNOS mRNA.
- Statin treatment and 3' polyadenylation of eNOS mRNA.
- Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression.
- Laminar shear stress and 3' polyadenylation of eNOS mRNA.
- Actin cytoskeleton organization and posttranscriptional regulation of endothelial nitric oxide synthase during cell growth.
- The nitric oxide pathway and oxidative stress in Heart failure.
- An accurate, precise method for general labeling of extracellular vesicles.
- Hypoxia Mediates Mutual Repression between microRNA-27a and PPARγ in the Pulmonary Vasculature.
- The Use of Molecular Beacons to Detect and Quantify MicroRNA.
- Endothelial mechanotransduction, nitric oxide and vascular inflammation.
- The interaction of nitric oxide, bradykinin, and the angiotensin II type 2 receptor: lessons learned from transgenic mice.
- Posttranscriptional regulation of endothelial nitric oxide synthase during cell growth.
- The effect of aluminum on markers for synaptic neurotransmission, cyclic AMP, and neurofilaments in a neuroblastoma x glioma hybridoma (NG108-15).
- The identification and characterization of a GABAergic system in the cholinergic neuroblastoma x glioma hybrid clone NG108-15.
- Effects of anticonvulsants on cholinergic and GABAergic properties in the neuronal cell clone NG108-15.
- MicroRNA Expression Profile in CAD Patients and the Impact of ACEI/ARB.
Schools
Georgetown University
Emory
Conditions Treated
- Angina and Acute Coronary Syndrome
- Aortic Ectasia
- Aortic Valve Disease
- Arrhythmias (incl. Atrial Fibrillation)
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Doctors Specialties
- Cardiology
Accepted Insurances
Education
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Emory University -
Georgetown University School of Medicine
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