Diana, Princess of Wales Professor of Cancer Research, Northwestern University Medical School

Pathology

Charles Clevenger is an expert in the field of Pathology. He researched medicine at Northwestern University Feinberg School of Medicine. Northwestern University Feinberg School of Medicine has a rank of 19 in research and a 29 in primary care He received awards:"Meaningful Use Stage 1 Certification" and "Elected Member". Charles Clevenger is a published MD. He has 70 publications published. The most current publication "Prolactin receptor signal transduction in cells of the immune system." He is registered with Medicare.

Publications

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• Immunoassay and Nb2 lymphoma bioassay prolactin levels and mammographic density in premenopausal and postmenopausal women the Nurses' Health Studies.
• Bioactive prolactin levels and risk of breast cancer: a nested case-control study.
• Comment on "Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast".
• The prolactin receptor transactivation domain is associated with steroid hormone receptor expression and malignant progression of breast cancer.
• Modulation of the nuclear antigen p105 as a function of cell-cycle progression.
• Simultaneous nuclear antigen and DNA content quantitation using paraffin-embedded colonic tissue and multiparameter flow cytometry.
• Expression of maturation-specific nuclear antigens in differentiating human myeloid leukemia cells.
• Identification of a nuclear protein component of interchromatin granules using a monoclonal antibody and immunogold electron microscopy.
• Murine leukemia virus infection in immunocompetent adult mice.
• Colchicine poisoning: report of a fatal case with body fluid analysis by GC/MS and histopathologic examination of postmortem tissues.
• Cyclophilins contribute to Stat3 signaling and survival of multiple myeloma cells.
• Molecular genetic testing from paraffin-embedded tissue distinguishes nonmolar hydropic abortion from hydatidiform mole.
• Flow cytometric analysis of DNA content in Hürthle cell adenomas and carcinomas of the thyroid.
• Prolactin as a second messenger for interleukin 2.
• Corticotropin-releasing factor mRNA in rat thymus and spleen.
• TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues.
• An old epithelial cell never dies, it just agonesces away.
• Detection of bone marrow breast carcinoma metastasis using multiparameter flow cytometry.
• A functional analysis of protooncogene Vav's role in adult human hematopoiesis.
• Requirement of nuclear prolactin for interleukin-2--stimulated proliferation of T lymphocytes.
• Vav is necessary for prolactin-stimulated proliferation and is translocated into the nucleus of a T-cell line.
• Requirement for prolactin during cell cycle regulated gene expression in cloned T-lymphocytes.
• Regulation of interleukin 2-driven T-lymphocyte proliferation by prolactin.
• Role of Bag-1 in the survival and proliferation of the cytokine-dependent lymphocyte lines, Ba/F3 and Nb2.
• Interleukin-2 driven nuclear translocation of prolactin in cloned T-lymphocytes.
• Prolactin induces rapid phosphorylation and activation of prolactin receptor-associated RAF-1 kinase in a T-cell line.
• Stoichiometric structure-function analysis of the prolactin receptor signaling domain by receptor chimeras.
• Role of cyclophilins in somatolactogenic action.
• Modulation of growth factor receptor function by isoform heterodimerization.
• Prolactin as a chemoattractant for human breast carcinoma.
• Translocation and action of polypeptide hormones within the nucleus. Relevance to lactogenic transduction.
• Prolactin receptor signal transduction.
• The protein tyrosine kinase P59fyn is associated with prolactin (PRL) receptor and is activated by PRL stimulation of T-lymphocytes.
• Stabilization of prolactin receptor in breast cancer cells.
• Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells.
• Prolactin as an autocrine/paracrine factor in breast tissue.
• Functional characterization of the intermediate isoform of the human prolactin receptor.
• Identification and characterization of the prolactin-binding protein in human serum and milk.
• Expression of prolactin and its receptor in human breast carcinoma.
• Activation and association of the Tec tyrosine kinase with the human prolactin receptor: mapping of a Tec/Vav1-receptor binding site.
• Role of cyclophilin B in prolactin signal transduction and nuclear retrotranslocation.
• Prolactin receptor signal transduction in cells of the immune system.
• Expression of prolactin and prolactin receptor in human breast carcinoma. Evidence for an autocrine/paracrine loop.
• The kinetics of binding human prolactin, but not growth hormone, to the prolactin receptor vary over a physiologic pH range.
• Ligand-independent dimerization of the human prolactin receptor isoforms: functional implications.
• Negative cross talk between NFAT1 and Stat5 signaling in breast cancer.
• HMGN2 inducibly binds a novel transactivation domain in nuclear PRLr to coordinate Stat5a-mediated transcription.
• Prolactin receptor-integrin cross-talk mediated by SIRP? in breast cancer cells.
• Reproducibility of plasma and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health Studies.
• Cyclophilin B as a co-regulator of prolactin-induced gene expression and function in breast cancer cells.
• New mechanisms for PRLr action in breast cancer.
• Expression of cyclophilin B is associated with malignant progression and regulation of genes implicated in the pathogenesis of breast cancer.
• Role of c-Myb during prolactin-induced signal transducer and activator of transcription 5a signaling in breast cancer cells.
• Energy balance, early life body size, and plasma prolactin levels in postmenopausal women.
• Prolyl isomerase cyclophilin A regulation of Janus-activated kinase 2 and the progression of human breast cancer.
• The isolation of novel mesenchymal stromal cell chemotactic factors from the conditioned medium of tumor cells.
• Quantification of PRL/Stat5 signaling with a novel pGL4-CISH reporter.
• Prolactin stimulates ubiquitination, initial internalization, and degradation of its receptor via catalytic activation of Janus kinase 2.
• From bench to bedside: future potential for the translation of prolactin inhibitors as breast cancer therapeutics.
• Altered expression of prolactin receptor-associated signaling proteins in human breast carcinoma.
• Role of prolactin/prolactin receptor signaling in human breast cancer.
• Signal transduction.
• Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.
• Roles and regulation of stat family transcription factors in human breast cancer.
• Nuclear localization and function of polypeptide ligands and their receptors: a new paradigm for hormone specificity within the mammary gland?
• A novel and functional interaction between cyclophilin A and prolactin receptor.
• The role of prolactin in mammary carcinoma.
• Characterization of a novel and functional human prolactin receptor isoform (deltaS1PRLr) containing only one extracellular fibronectin-like domain.
• The intranuclear prolactin/cyclophilin B complex as a transcriptional inducer.

Schools

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• NWU FIENBERG SCH OF MED

• University Of Pennsylvania

Doctors Specialties

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• Cytopathology
• Pathology

Accepted Insurances

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Awards

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• Meaningful Use Stage 1 Certification
• Elected Member

Education

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• University of Pennsylvania Health System
• Northwestern University Feinberg School of Medicine

Hospital

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• Northwestern Memorial Hospital

Helpful Reviews

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Medicare Facts

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National Provider Identifier [NPI]	1598728933
Last Name Of The Provider	CLEVENGER
First Name Of The Provider	CHARLES
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