ACS and Hardis Professor and Chairperson, Genomic Medicine Institute,
Director, Center for Personalized Genetic Healthcare,
Director, Cancer Genetics Clinical Services,
CLEVELAND CLINIC;
Professor and Vice Chair, Department of Genetics and Genome
Medical Genetics
Charis practices Medical Genetics. She went to medical school at University of Chicago Pritzker School of Medicine. University of Chicago Pritzker School of Medicine has a rank of 10 in research and a 19 in primary care She received awards:"American Medical Womens Association Exceptional Mentor Award", "James Ewing Lectureship", "American Medical Association Women Physicians Section Mentorship Recognition", "Highly Influential Biomedical Researchers (dead or alive) in the World", "Cleveland Magazines Best Doctors", "Deans Distinguished Lecturer", "Whos Who", "US News and World Report Top Doctor, Medical Oncology (Cancer Genetics)", "The 50 Best Cleveland Clinic Doctors Ever", "CMS Meaningful Use Stage 1 Certification", "Fellow", "Man of the Year", "Americas Top Physicians", "Elected Member", "America's Top Doctors", "America's Top Doctors for Cancer", "Best Doctors in the World", "Best Doctors", "Crains Cleveland Business Health Care Hero Nominee", "Distinguished Lecturership", "Top 10 Innovations for 2008", "Top Doctors in America", "John Peter Minton, MD, PhD Hero of Hope Research Medal of Honor", "Innovator Award", "Local Legend from Ohio", "Mortar Board and Sphinx Faculty Recognition Award", "The Donald V. Unverferth Award for Sustained Scholarly Excellence and Extraordinary Mentorship by a Faculty Member", "American Association for Cancer Research-Women in Cancer Research Distinguished Scientists Database", "American Thyroid Association Van Meter Award for Outstanding Research on the Thyroid Gland and Related Topics", "Fellowship", "Stephanie Spielman Breast Cancer Research Award", "Doris Duke Distinguished Clinical Scientist Award", "William C. and Joan E. Davis Professorship in Cancer Research", "Barr Investigatorship", "Patterson Fellowship", "The First Lawrence and Susan Marx Investigatorship in Human Cancer Genetics", "Lucille P. Markey Charitable Trust Young Scientist Award", "Johanna Wood Fellowship", "Cancer Research Campaign - Dana-Farber Cancer Institute Fellowship in Human Cancer Genetics", "Upjohn Travel Award", "Alpha Omega Alpha", "Sigma Xi, Full Membership", "American Heart Association - Borg-Warner Medical Student Research Fellowship", "National Institutes of Health Summer Research Fellowship", "Phi Beta Kappa", "Sigma Xi, Associate Membership", "Sigma Xi Science Prize Competition, Honorable Mention", "Sigma Xi Certificate of Merit for Excellence in Undergraduate Scientific Research", "Far East Scholarship", "Dean's Letter of Commendation for Excellence in Gross Anatomy and Microbiology", "Edmondson Summer Research Fellowship", "Yim Chan Merit Scholarship", "Dean's List", "Promoted Fellow", "Inaugural Lawrence and Susan Marx Investigator in Human Cancer Genetics", "Whos Who in Medicine and Healthcare", "Highly Influential Biomedical Researcher (Dead or Alive), 2013", "Women Physicians Section Mentorship Recognition", "Dean's Distinguished Lecturer", "The 2012 John S. Diekhoff Award for Excellence in Graduate Mentoring", "Lerner Research Institute Award for Excellence in Science", "The Lemuel Herrera Distinguished Lecturer", "Maria and Sam Miller Professional Excellence Award for Scientific Achievement in Clinical Research", "Cleveland Clinic Genomic Medicine Institute highlighted as Model for Future Genomic Medicine Institutes", "Cleveland Clinic Genomic Medicine Institute named as Institution of the Month", "John Peter Minton, MD, PhD Hero of Hope Research Medal of Honor (in the area of Clinical Research) in recognition of significant contributions to the advancement of cancer research in Ohio", "The Endocrine Society / Pfizer, Inc. International Finalist Award for Excellence in Published Clinical Research in J Clin Endocrinol Metab in 2005", "Ernst Oppenheimer Memorial Award for Outstanding Achievements in Endocrine Research", "Women in Cancer Research Distinguished Scientists Database", "Mortar Board and Sphinx Faculty Recognition Award for the single faculty mentor who has most greatly influenced a graduating undergraduate students academic career", "Local Legend from Ohio for women physicians who have demonstrated commitment, originality, innovation and/or creativity in their fields of medicine", "Elected Fellow", "Doris Duke Distinguished Clinical Scientist Award 2002-2009" and "Harry de Lozier Memorial Lecturership". Charis is a published MD. She has 102 papers published. The most current publication "The Urinary Microbiome Differs Significantly between Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Controls as Well as between Patients with Diffe..." She accepts Medicare payments and is registered with Medicare.gov.
Publications
- Germline PARP4 mutations in patients with primary thyroid and Breast cancers.
- Germline Heterozygous Variants in SEC23B Are Associated with Cowden Syndrome and Enriched in Apparently Sporadic Thyroid Cancer.
- Germline and somatic SDHx alterations in apparently sporadic differentiated thyroid Cancer.
- Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder.
- Pituitary adenoma with paraganglioma/pheochromocytoma (3PAs) and succinate dehydrogenase defects in human and mice.
- KLLN epigenotype-phenotype associations in Cowden syndrome.
- Cowden syndrome-associated germline SDHD variants alter PTEN nuclear translocation through SRC-induced PTEN oxidation.
- Communicating with Biobank Participants: Preferences for Receiving and Providing Updates to Researchers.
- Pulmonary arterial hypertension in a patient with Cowden syndrome and the PTEN mutation.
- Germline PTEN, SDHB-D, and KLLN alterations in endometrial Cancer patients with cowden and cowden-like syndromes: An international, multicenter, prospective study.
- Molecular and phenotypic abnormalities in individuals with germline heterozygous PTEN mutations and autism.
- PTEN Hamartoma Tumor Syndrome: Clinical Risk Assessment and Management Protocol.
- Exome sequencing in familial colorectal Cancer: searching for needles in haystacks.
- Transient abnormal myelopoiesis of a newborn not associated with chromosome 21 abnormalities or GATA1 mutations.
- Inflammatory disease of the aorta: Patterns and classification of giant Cell aortitis, Takayasu arteritis, and nonsyndromic aortitis.
- Nuclear KLLN expression associates with improved relapse-free survival for prostate Carcinoma.
- TERT and BRAF in Thyroid Cancer: Teaming Up for Trouble.
- Equality in Lynch Syndrome Screening: Why Should We Hold Patients With Endometrial Cancer to a Different Standard?
- Genetics of cognition in epilepsy.
- Germline Alterations in RASAL1 in Cowden Syndrome Patients Presenting with Follicular Thyroid Cancer and in Individuals with Apparently Sporadic Epithelial Thyroid Can...
- Time studies of the tasks associated with comprehensive Cancer genetics counseling.
- A Twin Study of Heritable and Shared Environmental Contributions to Autism.
- How to spot heritable Breast cancer: A primary care physician's guide.
- Activation of AR sensitizes breast Carcinomas to NVP-BEZ235's therapeutic effect mediated by PTEN and KLLN upregulation.
- Long-term prognosis of patients with pediatric pheochromocytoma.
- Increased prevalence of eosinophilic gastrointestinal Disorders (EGID) in pediatric PTEN hamartoma tumor syndromes (PHTS).
- Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis.
- The impact of pregnancy on Breast cancer survival in women who carry a BRCA1 or BRCA2 mutation.
- RASAL1 in Thyroid Cancer: Wisdom From an Old Foe.
- PTEN germline mutations in patients initially tested for other hereditary Cancer syndromes: would use of risk assessment tools reduce genetic testing?
- Demographic and clinical correlates of autism symptom domains and autism spectrum diagnosis.
- The development of a clinical screening instrument for tumour predisposition syndromes in childhood Cancer patients.
- A Time Study of Cancer Genetic Counselors Using a Genetic Counselor-Only Patient Care Model Versus a Traditional Combined Genetic Counselor Plus Medical Geneticist Car...
- Renal Cancer in von Hippel-Lindau disease and related syndromes.
- Population-based universal screening for lynch syndrome: ready, set... How?
- Epidemiology of autosomal-dominant polycystic kidney Disease: an in-depth clinical study for south-western Germany.
- The incidence of endometrial Cancer in women with BRCA1 and BRCA2 mutations: an international prospective cohort study.
- Germline and somatic KLLN alterations in Breast cancer dysregulate G2 arrest.
- Cowden syndrome-related mutations in PTEN associate with enhanced proteasome activity.
- Androgen receptor-induced tumor suppressor, KLLN, inhibits breast cancer growth and transcriptionally activates p53/p73-mediated apoptosis in breast Carcinomas.
- Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation.
- Molecular genetics to genomic medicine practice: at the heart of value-based delivery of healthcare.
- Biochemical screening and PTEN mutation analysis in individuals with autism spectrum Disorders and macrocephaly.
- Germline BAP1 mutation predisposes to familial clear-Cell renal Cell carcinoma.
- Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenoCarcinoma.
- When Overgrowth Bumps Into Cancer: The PTEN-Opathies.
- Implementing genomic medicine in the clinic: the future is here.
- Implementation of Tumor Testing for Lynch Syndrome in Endometrial Cancers at a Large Academic Medical Center.
- Implementation of universal microsatellite instability and immunohistochemistry screening for diagnosing lynch syndrome in a large academic medical center.
- cgaTOH: Extended Approach for Identifying Tracts of Homozygosity.
- Cognitive characteristics of PTEN hamartoma tumor syndromes.
- Brothers with germline PTEN mutations and persistent hypoglycemia, macrocephaly, developmental delay, short stature, and coagulopathy.
- Prevalence of Germline PTEN, BMPR1A, SMAD4, STK11, and ENG Mutations in Patients with Moderate-Load Colorectal Polyps.
- Transcription Factor KLLN Inhibits Tumor Growth by AR Suppression, Induces Apoptosis by TP53/TP73 Stimulation in Prostate Carcinomas, and Correlates With Cellular Diff...
- Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes.
- Upper and Lower Gastrointestinal Findings in PTEN Mutation-Positive Cowden Syndrome Patients Participating in an Active Surveillance Program.
- The clinical consequences of hemizygosity across 2 MB of 10q23 are restricted to Cowden syndrome.
- Should patients with Cowden syndrome undergo prophylactic Thyroidectomy?
- Utility of PTEN Protein Dosage in Predicting for Underlying Germline PTEN Mutations among Patients Presenting with Thyroid Cancer and Cowden-Like Phenotypes.
- Characteristics of intracranial aneurysms in the else kroner-fresenius registry of autosomal dominant polycystic kidney Disease.
- PTEN Lipid Phosphatase Activity and Proper SubCellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndr...
- Breastfeeding and the risk of Breast cancer in BRCA1 and BRCA2 mutation carriers.
- Vitamin E protects against lipid peroxidation and rescues tumorigenic phenotypes in cowden/cowden-like patient-derived lymphoblast Cells with germline SDHx variants.
- Obesity, diabetes mellitus, and Cancer.
- Engaging basic scientists in translational research: identifying opportunities, overcoming obstacles.
- The prevalence of hereditary hemorrhagic telangiectasia in juvenile polyposis syndrome.
- Oophorectomy after menopause and the risk of Breast cancer in BRCA1 and BRCA2 mutation carriers.
- Lifetime Cancer Risks of PTEN Mutation Carriers--Response.
- PTEN hamartoma tumor syndrome and Gorham-Stout phenomenon.
- Evil lurks in the heart of man: cardiac paraganglioma presenting as recurrent dyspnoea and chronic cough.
- Chromosome 3 status in uveal melanoma: a comparison of fluorescence in situ hybridization and single-nucleotide polymorphism array.
- Elevated plasma succinate in PTEN, SDHB, and SDHD mutation-positive individuals.
- Engaging basic scientists in translational research.
- Estimate of de novo mutation frequency in probands with PTEN hamartoma tumor syndrome.
- Personalised care and the genome.
- A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer Cell lines.
- Biallelic inactivation of the SDHC gene in renal Carcinoma associated with paraganglioma syndrome type 3.
- Personalizing patient care.
- Papillary Renal Cell Carcinoma Is Associated With PTEN Hamartoma Tumor Syndrome.
- Autoimmunity, intestinal lymphoid hyperplasia, and defects in mucosal B-Cell homeostasis in patients with PTEN hamartoma tumor syndrome.
- The risk of Breast cancer in women with a BRCA1 mutation from North America and Poland.
- Prospective comparison of family medical history with personal genome screening for risk assessment of common Cancers.
- PTEN hamartoma of soft tissue: a distinctive lesion in PTEN syndromes.
- Building an innovative model for personalized healthcare.
- Microbiomic subprofiles and MDR1 promoter methylation in head and neck squamous Cell carcinoma.
- Characterization of the colorectal Cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583.
- Integrated analysis reveals critical genomic regions in prostate tumor microenvironment associated with clinicopathologic phenotypes.
- Integrative genomic analysis reveals extended germline homozygosity with lung Cancer risk in the PLCO cohort.
- Specific kinesin expression profiles associated with taxane resistance in Basal-like breast cancer.
- Lifetime Cancer risks in individuals with germline PTEN mutations.
- GATA2 negatively regulates PTEN by preventing nuclear translocation of androgen receptor and by androgen-independent suppression of PTEN transcription in Breast cancer.
- Germline SDHx variants modify Breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53.
- Validation of Proposed DSM-5 Criteria for Autism Spectrum Disorder.
- Incidence and clinical characteristics of thyroid Cancer in prospective series of individuals with Cowden and Cowden-like syndrome characterized by germline PTEN, SDH...
- A large health system's approach to utilization of the genetic counselor CPT(R) 96040 code.
- Differential regulation of PTEN expression by androgen receptor in prostate and Breast cancers.
- Age-related penetrance of hereditary atypical hemolytic uremic syndrome.
- Microenvironmental genomic alterations reveal signaling networks for head and neck squamous Cell carcinoma.
- Multiple endocrine neoplasia type 2: an overview.
- Germline mutations of the TMEM127 gene in patients with paraganglioma of head and neck and extraadRenal abdominal sites.
- The Urinary Microbiome Differs Significantly between Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Controls as Well as between Patients with Diffe...
Schools
U Of Chgo Div Of Bio Sci Pritzker Sch Of Med
Beth Israel Hospital
Dana Farber Cancer InstHar
Conditions Treated
- Anemia
- Basal Cell Carcinoma
- Breast Cancer
- Coagulation Disorders (incl. Hemophilia)
- View All
Doctors Specialties
- Medical Oncology
- Oncology
- Medical Genetics
Accepted Insurances
Awards
- American Medical Women’s Association Exceptional Mentor Award
- James Ewing Lectureship
- American Medical Association Women Physicians’ Section Mentorship Recognition
- Highly Influential Biomedical Researchers (dead or alive) in the World
- Cleveland Magazine’s Best Doctors
- Dean’s Distinguished Lecturer
- Who’s Who
- US News and World Report Top Doctor, Medical Oncology (Cancer Genetics)
- The 50 Best Cleveland Clinic Doctors – Ever
- CMS Meaningful Use Stage 1 Certification
- Fellow
- Man of the Year
- America’s Top Physicians
- Elected Member
- America's Top Doctors
- America's Top Doctors for Cancer
- Best Doctors in the World
- Best Doctors
- Crain’s Cleveland Business Health Care Hero Nominee
- Distinguished Lecturership
- Top 10 Innovations for 2008
- Top Doctors in America
- John Peter Minton, MD, PhD Hero of Hope Research Medal of Honor
- Innovator Award
- Local Legend from Ohio
- Mortar Board and Sphinx Faculty Recognition Award
- The Donald V. Unverferth Award for Sustained Scholarly Excellence and Extraordinary Mentorship by a Faculty Member
- American Association for Cancer Research-Women in Cancer Research Distinguished Scientists Database
- American Thyroid Association Van Meter Award for Outstanding Research on the Thyroid Gland and Related Topics
- Fellowship
- Stephanie Spielman Breast Cancer Research Award
- Doris Duke Distinguished Clinical Scientist Award
- William C. and Joan E. Davis Professorship in Cancer Research
- Barr Investigatorship
- Patterson Fellowship
- The First Lawrence and Susan Marx Investigatorship in Human Cancer Genetics
- Lucille P. Markey Charitable Trust Young Scientist Award
- Johanna Wood Fellowship
- Cancer Research Campaign - Dana-Farber Cancer Institute Fellowship in Human Cancer Genetics
- Upjohn Travel Award
- Alpha Omega Alpha
- Sigma Xi, Full Membership
- American Heart Association - Borg-Warner Medical Student Research Fellowship
- National Institutes of Health Summer Research Fellowship
- Phi Beta Kappa
- Sigma Xi, Associate Membership
- Sigma Xi Science Prize Competition, Honorable Mention
- Sigma Xi Certificate of Merit for Excellence in Undergraduate Scientific Research
- Far East Scholarship
- Dean's Letter of Commendation for Excellence in Gross Anatomy and Microbiology
- Edmondson Summer Research Fellowship
- Yim Chan Merit Scholarship
- Dean's List
- Promoted Fellow
- Inaugural Lawrence and Susan Marx Investigator in Human Cancer Genetics
- Whos Who in Medicine and Healthcare
- Highly Influential Biomedical Researcher (Dead or Alive), 2013
- Women Physicians’ Section Mentorship Recognition
- Dean's Distinguished Lecturer
- The 2012 John S. Diekhoff Award for Excellence in Graduate Mentoring
- Lerner Research Institute Award for Excellence in Science
- The Lemuel Herrera Distinguished Lecturer
- Maria and Sam Miller Professional Excellence Award for Scientific Achievement in Clinical Research
- Cleveland Clinic Genomic Medicine Institute highlighted as Model for Future Genomic Medicine Institutes
- Cleveland Clinic Genomic Medicine Institute named as Institution of the Month
- John Peter Minton, MD, PhD Hero of Hope Research Medal of Honor (in the area of Clinical Research) in recognition of significant contributions to the advancement of cancer research in Ohio
- The Endocrine Society / Pfizer, Inc. International Finalist Award for Excellence in Published Clinical Research in J Clin Endocrinol Metab in 2005
- Ernst Oppenheimer Memorial Award for Outstanding Achievements in Endocrine Research
- Women in Cancer Research Distinguished Scientists Database
- Mortar Board and Sphinx Faculty Recognition Award for the single faculty mentor who has most greatly influenced a graduating undergraduate student’s academic career
- Local Legend from Ohio for women physicians who have demonstrated commitment, originality, innovation and/or creativity in their fields of medicine
- Elected Fellow
- Doris Duke Distinguished Clinical Scientist Award 2002-2009
- Harry de Lozier Memorial Lecturership
Education
-
Beth Israel Deaconess Medical Center
-
University of Chicago Pritzker School of Medicine
-
University of Chicago
Hospital
-
Cleveland Clinic
Helpful Reviews
Give
Anonymous Review
Medicare Facts
| National Provider Identifier [NPI] |
1912985383 |
| Last Name Of The Provider |
ENG |
| First Name Of The Provider |
CHARIS |
| View All |
|
Similar Doctors
Doctor Directory | TOS | twitter | FB | Angel | blog
This Doctor is OpenDoctor Recommended.