Physician
Pathology
Dr. Carole A. Vogler, MD
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Carole Vogler is an expert in the field of Pathology. She researched medicine at University of Missouri-Columbia School of Medicine. Carole Vogler is a published doctor and has 97 publications published. The lastest was: 'Hypertrophic cardiomyopathy in a newborn infant.' Carole Vogler accepts Medicare.
Publications
- Disease correction by combined neonatal intracranial AAV and systemic lentiviral gene therapy in Sanfilippo Syndrome type B mice.
- The final frontier - crossing the blood-brain barrier.
- Deceptively benign low-grade fibromyxoid sarcoma: array-comparative genomic hybridization decodes the diagnosis.
- Bone marrow transplantation augments the effect of brain- and spinal cord-directed adeno-associated virus 2/5 gene therapy by altering inflammation in the murine model...
- Replacing the enzyme alpha-L-iduronidase at birth ameliorates symptoms in the brain and periphery of dogs with mucopolysaccharidosis type I.
- Early versus late treatment of spinal cord compression with long-term intrathecal enzyme replacement therapy in canine mucopolysaccharidosis type I.
- Lentiviral-transduced human mesenchymal stem cells persistently express therapeutic levels of enzyme in a xenotransplantation model of human disease.
- Attenuation of murine lysosomal storage disease by allogeneic neonatal bone marrow transplantation using costimulatory blockade and donor lymphocyte infusion without m...
- Transplanted ER-MP12hi20-58med/hi myeloid progenitors produce resident macrophages from marrow that are therapeutic for lysosomal storage disease.
- Intravitreal gene therapy reduces lysosomal storage in specific areas of the CNS in mucopolysaccharidosis VII mice.
- Viral infections of the fetus and the neonate.
- Glomerular membranopathy in children with IgA nephropathy and Henoch Schönlein purpura.
- Glomerular basement membrane and lamina densa in infants and children: an ultrastructural evaluation.
- Placental pathology for the surgical pathologist.
- Role of influenza B virus in hepatic steatosis and mitochondrial abnormalities in a mouse model of Reye syndrome.
- Bone marrow transplantation in type IIa glycogen storage disease.
- Hypertrophic cardiomyopathy in a newborn infant.
- Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns.
- Sclerosing cholangitis, inflammatory bowel disease, and glomerulonephritis: a case report of a rare triad.
- Valproate use associated with persistent hyperammonemia and mitochondrial injury in a child with Down's syndrome.
- Microangiopathic glomerulopathy in children with sickle cell anemia.
- Renal pathology in the pediatric transplant patient.
- Pericardial cysts in children: surgical or conservative approach?
- Clinicopathologic conference: neurologic dysfunction in a premature infant.
- Electron microscopy in the diagnosis of lysosomal storage diseases.
- Gene therapy for lysosomal storage disease: a no-brainer? Transplants of fibroblasts secreting high levels of beta-glucuronidase decrease lesions in the brains of mice...
- Glycosylation-independent targeting enhances enzyme delivery to lysosomes and decreases storage in mucopolysaccharidosis type VII mice.
- A teenage boy with late onset hemophagocytic lymphohistiocytosis with predominant neurologic disease and perforin deficiency.
- Adenovirus-mediated gene transfer and expression of human beta-glucuronidase gene in the liver, spleen, and central nervous system in mucopolysaccharidosis type VII mice.
- Murine model (Galns(tm(C76S)slu)) of MPS IVA with missense mutation at the active site cysteine conserved among sulfatase proteins.
- Correction of murine mucopolysaccharidosis VII by a human beta-glucuronidase transgene.
- Clinical and pathologic findings in two new allelic murine models of polycystic kidney disease.
- New strategies for enzyme replacement therapy for lysosomal storage diseases.
- Brain-directed gene therapy for lysosomal storage disease: going well beyond the blood- brain barrier.
- Murine mucopolysaccharidosis type VII. Characterization of a mouse with beta-glucuronidase deficiency.
- Infused Fc-tagged beta-glucuronidase crosses the placenta and produces clearance of storage in utero in mucopolysaccharidosis VII mice.
- Pathology of the ear in murine mucopolysaccharidosis type VII. Morphologic correlates of hearing loss.
- Production of MPS VII mouse (Gus(tm(hE540A x mE536A)Sly)) doubly tolerant to human and mouse beta-glucuronidase.
- Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.
- AAV vector integration sites in mouse hepatocellular carcinoma.
- Glycosaminoglycan storage in neuroanatomical regions of mucopolysaccharidosis I dogs following intrathecal recombinant human iduronidase.
- Murine mucopolysaccharidosis VIL: impact of therapies on the phenotype, clinical course, and pathology in a model of a lysosomal storage disease.
- Mouse model of N-acetylgalactosamine-6-sulfate sulfatase deficiency (Galns-/-) produced by targeted disruption of the gene defective in Morquio A disease.
- Mucopolysaccharidosis VII: postmortem biochemical and pathological findings in a young adult with beta-glucuronidase deficiency.
- Defining the pathway for Tat-mediated delivery of beta-glucuronidase in cultured cells and MPS VII mice.
- A murine model of mucopolysaccharidosis VII. Gross and microscopic findings in beta-glucuronidase-deficient mice.
- Active site mutant transgene confers tolerance to human beta-glucuronidase without affecting the phenotype of MPS VII mice.
- A murine model of infantile neuronal ceroid lipofuscinosis-ultrastructural evaluation of storage in the central nervous system and viscera.
- Neuropathology of murine mucopolysaccharidosis type VII.
- Development of sensory, motor and behavioral deficits in the murine model of Sanfilippo syndrome type B.
- Enzyme replacement with recombinant beta-glucuronidase in the newborn mucopolysaccharidosis type VII mouse.
- Acidic amino acid tag enhances response to enzyme replacement in mucopolysaccharidosis type VII mice.
- Electrocardiographic and other cardiac anomalies in beta-glucuronidase-null mice corrected by nonablative neonatal marrow transplantation.
- Overcoming the blood-brain barrier with high-dose enzyme replacement therapy in murine mucopolysaccharidosis VII.
- Transgene produces massive overexpression of human beta -glucuronidase in mice, lysosomal storage of enzyme, and strain-dependent tumors.
- A novel model of murine mucopolysaccharidosis type VII due to an intracisternal a particle element transposition into the beta-glucuronidase gene: clinical and patholo...
- Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors.
- Chemically modified beta-glucuronidase crosses blood-brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII.
- Murine mucopolysaccharidosis type VII: the impact of therapies on the clinical course and pathology in a murine model of lysosomal storage disease.
- Enzyme replacement therapy improves reproductive performance in mucopolysaccharidosis type VII mice but does not prevent postnatal losses.
- Enzyme replacement therapy for murine mucopolysaccharidosis type VII.
- Gene therapy for murine mucopolysaccharidosis type VII.
- Neonatal intramuscular injection with recombinant adeno-associated virus results in prolonged beta-glucuronidase expression in situ and correction of liver pathology i...
- Early onset of lysosomal storage disease in a murine model of mucopolysaccharidosis type VII: undegraded substrate accumulates in many tissues in the fetus and very yo...
- Murine mucopolysaccharidosis type VII: long term therapeutic effects of enzyme replacement and enzyme replacement followed by bone marrow transplantation.
- Syngeneic bone marrow transplantation reduces the hearing loss associated with murine mucopolysaccharidosis type VII.
- Biodistribution and efficacy of donor T lymphocytes in a murine model of lysosomal storage disease.
- Retinal function is improved in a murine model of a lysosomal storage disease following bone marrow transplantation.
- Numerous transcriptional alterations in liver persist after short-term enzyme-replacement therapy in a murine model of mucopolysaccharidosis type VII.
- Human CD34+ hematopoietic progenitor cell-directed lentiviral-mediated gene therapy in a xenotransplantation model of lysosomal storage disease.
- Adeno-associated virus 2-mediated gene therapy decreases autofluorescent storage material and increases brain mass in a murine model of infantile neuronal ceroid lipof...
- AAV2/5 vector expressing galactocerebrosidase ameliorates CNS disease in the murine model of globoid-cell leukodystrophy more efficiently than AAV2.
- Prevention of systemic clinical disease in MPS VII mice following AAV-mediated neonatal gene transfer.
- Biodistribution, kinetics, and efficacy of highly phosphorylated and non-phosphorylated beta-glucuronidase in the murine model of mucopolysaccharidosis VII.
- Intracranial injection of recombinant adeno-associated virus improves cognitive function in a murine model of mucopolysaccharidosis type VII.
- Nonablative neonatal marrow transplantation attenuates functional and physical defects of beta-glucuronidase deficiency.
- Engraftment of human CD34+ cells leads to widespread distribution of donor-derived cells and correction of tissue pathology in a novel murine xenotransplantation model...
- Missense models [Gustm(E536A)Sly, Gustm(E536Q)Sly, and Gustm(L175F)Sly] of murine mucopolysaccharidosis type VII produced by targeted mutagenesis.
- Enzyme replacement with recombinant beta-glucuronidase in murine mucopolysaccharidosis type VII: impact of therapy during the first six weeks of life on subsequent lys...
- Treatment of murine mucopolysaccharidosis type VII by syngeneic bone marrow transplantation in neonates.
- Increased life span and correction of metabolic defects in murine mucopolysaccharidosis type VII after syngeneic bone marrow transplantation.
- Reversal of pathology in murine mucopolysaccharidosis type VII by somatic cell gene transfer.
- Enzyme replacement therapy for murine mucopolysaccharidosis type VII leads to improvements in behavior and auditory function.
- Neonatal gene transfer leads to widespread correction of pathology in a murine model of lysosomal storage disease.
- Behavior and therapeutic efficacy of beta-glucuronidase-positive mononuclear phagocytes in a murine model of mucopolysaccharidosis type VII.
- Enzyme replacement in murine mucopolysaccharidosis type VII: neuronal and glial response to beta-glucuronidase requires early initiation of enzyme replacement therapy.
- Therapeutic efficacy of bone marrow transplant, intracranial AAV-mediated gene therapy, or both in the mouse model of MPS IIIB.
- Clinical response to persistent, low-level beta-glucuronidase expression in the murine model of mucopolysaccharidosis type VII.
- Central nervous system-directed AAV2/5-mediated gene therapy synergizes with bone marrow transplantation in the murine model of globoid-cell leukodystrophy.
- Intrathecal enzyme replacement therapy: successful treatment of brain disease via the cerebrospinal fluid.
- A genetically myeloablated MPS VII model detects the expansion and curative properties of as few as 100 enriched murine stem cells.
- In utero fetal liver cell transplantation without toxic irradiation alleviates lysosomal storage in mice with mucopolysaccharidosis type VII.
- Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I.
- Neonatal retroviral vector-mediated hepatic gene therapy reduces bone, joint, and cartilage disease in mucopolysaccharidosis VII mice and dogs.
- Donor cell replacement in mice transplanted in utero is limited by immune-independent mechanisms.
- Donor cell expansion is delayed following nonablative in utero transplantation to treat murine mucopolysaccharidosis type VII.
Schools
University Of MissouriColumbia School Of Medicine
University Tex
Chldns Hospital
Doctors Specialties
- Pediatric Pathology
- Pathology
Accepted Insurances
Education
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Cincinnati Children's Hospital Medical Center -
University of Texas Health Science Center -
University of Missouri-Columbia School of Medicine
Hospital
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SSM Cardinal Glennon Children's Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1063465466 |
| Last Name Of The Provider | VOGLER |
| First Name Of The Provider | CAROLE |
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