Physician
Pediatric Infectious Disease
Dr. Bruce S. Klein, MD
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Bruce Klein works in the field of Pediatric Infectious Disease. He researched medicine at Boston University School of Medicine. Boston University School of Medicine has a rank of 30 in research and a 52 in primary care Bruce Klein is a published doctor as well. He has 99 publications published. The latest was: Immunogenicity and protective efficacy of the WI-1 adhesin of Blastomyces dermatitidis. Bruce Klein is registered with Medicare and accepts Medicare payments.
Publications
- Calnexin Induces Expansion of Antigen-Specific CD4(+) T Cells that Confer Immunity to Fungal Ascomycetes via Conserved Epitopes.
- The unappreciated intracellular lifestyle of Blastomyces dermatitidis.
- Adaptive Immunity to Fungi.
- IL-1 receptor but not Toll-like receptor 2 is essential for MyD88-dependent Th17 immunity to Coccidioides infection.
- Vaccine immunity against fungal infections.
- C-Type Lectin Receptors Differentially Induce Th17 Cells and Vaccine Immunity to the Endemic Mycosis of North America.
- Novel Strategies to Enhance Vaccine Immunity against Coccidioidomycosis.
- Development of a Highly Sensitive and Specific Blastomycosis Antibody Enzyme Immunoassay Using Blastomyces dermatitidis Surface Protein BAD-1.
- A large community outbreak of blastomycosis in wisconsin with geographic and ethnic clustering.
- Structure and Function of a Fungal Adhesin that Binds Heparin and Mimics Thrombospondin-1 by Blocking T Cell Activation and Effector Function.
- Fungal glycan interactions with epithelial cells in allergic airway disease.
- Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action.
- Isolation of Blastomyces dermatitidis yeast from lung tissue during murine infection for in vivo transcriptional profiling.
- Identification of the mating-type (MAT) locus that controls sexual reproduction of Blastomyces dermatitidis.
- Chitin Elicits CCL2 from Airway Epithelial Cells and Induces CCR2-Dependent Innate Allergic Inflammation in the Lung.
- Tc17 Cells Mediate Vaccine Immunity against Lethal Fungal Pneumonia in Immune Deficient Hosts Lacking CD4(+) T Cells.
- Dendritic cells in antifungal immunity and vaccine design.
- Fungi Subvert Vaccine T Cell Priming at the Respiratory Mucosa by Preventing Chemokine-Induced Influx of Inflammatory Monocytes.
- Limited model antigen expression by transgenic fungi induces disparate fates during differentiation of adoptively transferred TCR Tg CD4+ T cells: robust activation an...
- Vaccine Immunity to Coccidioidomycosis Occurs by Early Activation of Three Signal Pathways of T Helper Cell Response (Th1, Th2 and Th17).
- A TCR Transgenic Mouse Reactive with Multiple Systemic Dimorphic Fungi.
- Safety, Tolerability, and Immunogenicity of a Recombinant, Genetically Engineered, Live-Attenuated Vaccine against Canine Blastomycosis.
- Blastomyces dermatitidis yeast inhibit nitric oxide production by the alveolar macrophage inducible nitric oxide synthase.
- Non-Rural Point Source Blastomycosis Outbreak Near a Yard Waste Collection Site.
- Dynamic interplay among monocyte-derived, dermal, and resident lymph node dendritic cells during the generation of vaccine immunity to fungi.
- Discordant influence of Blastomyces dermatitidis yeast-phase-specific gene BYS1 on morphogenesis and virulence.
- SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis.
- Insights into Fungal Morphogenesis and Immune Evasion: Fungal conidia, when situated in mammalian lungs, may switch from mold to pathogenic yeasts or spore-forming sph...
- V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis.
- Detection and measurement of two-component systems that control dimorphism and virulence in fungi.
- Differential requirements of T cell subsets for CD40 costimulation in immunity to Blastomyces dermatitidis.
- Global control of dimorphism and virulence in fungi.
- Immunotherapy for fungal infections.
- Calcium binding by the essential virulence factor BAD-1 of Blastomyces dermatitidis.
- CD28 is required for optimal induction, but not maintenance, of vaccine-induced immunity to Blastomyces dermatitidis.
- IL-12 is required for induction but not maintenance of protective, memory responses to Blastomyces dermatitidis: implications for vaccine development in immune-deficie...
- Exploiting type 3 complement receptor for TNF-alpha suppression, immune evasion, and progressive pulmonary fungal infection.
- Sequence elements necessary for transcriptional activation of BAD1 in the yeast phase of Blastomyces dermatitidis.
- Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in ...
- Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts.
- Agrobacterium tumefaciens integrates transfer DNA into single chromosomal sites of dimorphic fungi and yields homokaryotic progeny from multinucleate yeast.
- BAD1, an essential virulence factor of Blastomyces dermatitidis, suppresses host TNF-alpha production through TGF-beta-dependent and -independent mechanisms.
- Reduction of nosocomial infection during pediatric intensive care by protective isolation.
- Kawasaki syndrome: a controlled study of an outbreak in Wisconsin.
- Nosocomial hepatitis A. A multinursery outbreak in Wisconsin.
- Recognition by human V gamma 9/V delta 2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells.
- Comparison of the enzyme immunoassay, immunodiffusion, and complement fixation tests in detecting antibody in human serum to the A antigen of Blastomyces dermatitidis.
- Virulence factors of medically important fungi.
- A laboratory-based surveillance of human blastomycosis in Wisconsin between 1973 and 1982.
- Campylobacter infection associated with raw milk. An outbreak of gastroenteritis due to Campylobacter jejuni and thermotolerant Campylobacter fetus subsp fetus.
- Nosocomial Pseudomonas pickettii bacteremias traced to narcotic tampering. A case for selective drug screening of health care personnel.
- Microbiology. Turning up the heat on Histoplasma capsulatum.
- Protective antifungal memory CD8+ T cells are maintained in the absence of CD4+ T cell help and cognate antigen in mice.
- Flow cytometric quantitation of yeast a novel technique for use in animal model work and in vitro immunologic assays.
- Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice.
- Epidemiologic aspects of blastomycosis, the enigmatic systemic mycosis.
- T-Cell epitopes and human leukocyte antigen restriction elements of an immunodominant antigen of Blastomyces dermatitidis.
- Development of long-term specific cellular immunity after acute Blastomyces dermatitidis infection: assessments following a large point-source outbreak in Wisconsin.
- Indirect regulation of CD4 T-cell responses by tumor necrosis factor receptors in an acute viral infection.
- Role of cell surface molecules of Blastomyces dermatitidis in the pathogenesis and immunobiology of blastomycosis.
- Isolation of Blastomyces dermatitidis in soil associated with a large outbreak of blastomycosis in Wisconsin.
- Serological tests for blastomycosis: assessments during a large point-source outbreak in Wisconsin.
- Genomic cloning, characterization, and functional analysis of the major surface adhesin WI-1 on Blastomyces dermatitidis yeasts.
- Transforming DNA integrates at multiple sites in the dimorphic fungal pathogen Blastomyces dermatitidis.
- Blastomycosis in solid organ transplant recipients.
- Utility of anti-WI-1 serological testing in the diagnosis of blastomycosis in Wisconsin residents.
- Investigation of anti-WI-1 adhesin antibody-mediated protection in experimental pulmonary blastomycosis.
- Role of cell-surface molecules of Blastomyces dermatitidis in host-pathogen interactions.
- Molecular basis of pathogenicity in Blastomyces dermatitidis: the importance of adhesion.
- The WI-1 antigen of Blastomyces dermatitidis yeasts mediates binding to human macrophage CD11b/CD18 (CR3) and CD14.
- Altered expression of surface alpha-1,3-glucan in genetically related strains of Blastomyces dermatitidis that differ in virulence.
- African strains of Blastomyces dermatitidis that do not express surface adhesin WI-1.
- Immunogenicity and protective efficacy of the WI-1 adhesin of Blastomyces dermatitidis.
- Two outbreaks of blastomycosis along rivers in Wisconsin. Isolation of Blastomyces dermatitidis from riverbank soil and evidence of its transmission along waterways.
- Canine antibody response to Blastomyces dermatitidis WI-1 antigen.
- Molecular genetic analysis of Blastomyces dermatitidis reveals new insights about pathogenic mechanisms.
- A C-terminal EGF-like domain governs BAD1 localization to the yeast surface and fungal adherence to phagocytes, but is dispensable in immune modulation and pathogenici...
- Selective expression of the virulence factor BAD1 upon morphogenesis to the pathogenic yeast form of Blastomyces dermatitidis: evidence for transcriptional regulation ...
- Isolation, purification, and radiolabeling of a novel 120-kD surface protein on Blastomyces dermatitidis yeasts to detect antibody in infected patients.
- Immunologic recognition of a 25-amino acid repeat arrayed in tandem on a major antigen of Blastomyces dermatitidis.
- Mutation of the WI-1 gene yields an attenuated blastomyces dermatitidis strain that induces host resistance.
- Development and application of a green fluorescent protein sentinel system for identification of RNA interference in Blastomyces dermatitidis illuminates the role of s...
- The WI-1 adhesin blocks phagocyte TNF-alpha production, imparting pathogenicity on Blastomyces dermatitidis.
- Interleukin 12 as an adjuvant to WI-1 adhesin immunization augments delayed-type hypersensitivity, shifts the subclass distribution of immunoglobulin G antibodies, and...
- Altered expression of surface protein WI-1 in genetically related strains of Blastomyces dermatitidis that differ in virulence regulates recognition of yeasts by human...
- Purification and characterization of the major antigen WI-1 from Blastomyces dermatitidis yeasts and immunological comparison with A antigen.
- WI-1, a novel 120-kilodalton surface protein on Blastomyces dermatitidis yeast cells, is a target antigen of cell-mediated immunity in human blastomycosis.
- Role of glucan and surface protein BAD1 in complement activation by Blastomyces dermatitidis yeast.
- Cluster of pulmonary blastomycosis in a rural community: evidence for multiple high-risk environmental foci following a sustained period of diminished precipitation.
- Linking fungal morphogenesis with virulence.
- Using new genetic tools to study the pathogenesis of Blastomyces dermatitidis.
- Progress in vaccination for histoplasmosis and blastomycosis: coping with cellular immunity.
- Analysis of non-adhesive pathogenic mechanisms of BAD1 on Blastomyces dermatitidis.
- Advances in combating fungal diseases: vaccines on the threshold.
- Genetic diversity in Blastomyces dermatitidis: implications for PCR detection in clinical and environmental samples.
- Fungal adaptation to the mammalian host: it is a new world, after all.
- Dimorphism and virulence in fungi.
- Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity.
Schools
Boston University School Of Medicine
Doctors Specialties
- Pediatrics
- Pediatric Infectious Disease
Accepted Insurances
Education
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University of Wisconsin -
Johns Hopkins University -
Boston University School of Medicine
Hospital
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Meriter UnityPoint Health -
University of Wisconsin Hospital and Clinics
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