Professor of Medicine, Beth Israel Deaconess Medical Center
Hematology
Dr. Bruce Furie, MD
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Bruce Furie, MD practices Hematology. He went to medical school at SUNY Upstate Medical University. He over the years received 2 awards: "Regional Top Doctor" and "Elected Member". Bruce Furie is a published doctor and has 101 publications published. The lastest was: 'Proteins of the exocytotic core complex mediate platelet alpha-granule secretion. Roles of vesicle-associated membrane protein, SNAP-23, and syntaxin 4.' He accepts all Medicare patients.
Publications
- Extracellular Thiol Isomerases and Their Role in Thrombus Formation.
- Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria.
- Both platelet- and endothelial cell-derived ERp5 supports thrombus formation in a laser-induced mouse model of Thrombosis.
- How I treat: poisoning with vitamin K antagonists.
- Platelets are required for enhanced activation of the endothelium and fibrinogen in a mouse Thrombosis model of APS.
- Do Pharmacogenetics Have a Role in the Dosing of Vitamin K Antagonists?
- Formation of the clot.
- Separation of human plasma factor IX from HTLV-I or HIV by immunoaffinity chromatography using conformation-specific antibodies.
- The second kringle domain of prothrombin promotes factor Va-mediated prothrombin activation by prothrombinase.
- Des-gamma-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma.
- Binding of human factor VIII to phospholipid vesicles.
- Thrombus imaging in a primate model with antibodies specific for an external membrane protein of activated Platelets.
- Proteins of the exocytotic core complex mediate Platelet alpha-granule secretion. Roles of vesicle-associated membrane protein, SNAP-23, and syntaxin 4.
- Propeptide processing during factor IX biosynthesis. Effect of point mutations adjacent to the propeptide cleavage site.
- Molecular Defects of factor IX Chicago-2 (Arg 145----His) and prothrombin Madrid (Arg 271----cys): arginine mutations that preclude zymogen activation.
- Surreptitious ingestion of a long-acting vitamin K antagonist/rodenticide, brodifacoum: clinical and metabolic studies of three cases.
- Effect of propeptide mutations on post-translational processing of factor IX. Evidence that beta-hydroxylation and gamma-carboxylation are independent events.
- Thrombus formation: direct real-time observation and digital analysis of thrombus assembly in a living mouse by confocal and widefield intravital microscopy.
- Structure determination of two conotoxins from Conus textile by a combination of matrix-assisted laser desorption/ionization time-of-flight and electrospray ionization...
- Randomized prospective trial comparing the native prothrombin antigen with the prothrombin time for monitoring oral anticoagulant therapy.
- P-selectin induction of tissue factor biosynthesis and expression.
- Histidine phosphorylation of P-selectin upon stimulation of human Platelets: a novel pathway for activation-dependent signal transduction.
- Refinement of the NMR solution structure of the gamma-carboxyglutamic acid domain of Coagulation factor IX using molecular dynamics simulation with initial Ca2+ positi...
- The interaction of prothrombin with phospholipid membranes is independent of either kringle domain.
- Metal binding sites of a gamma-carboxyglutamic acid-rich fragment of bovine prothrombin.
- Distribution of gamma-carboxyglutamic acid residues in partially carboxylated human prothrombins.
- PADGEM: an adhesion receptor for leukocytes on stimulated Platelets and endothelial cells.
- Detection of distinct isoform patterns of the beta-amyloid precursor protein in human Platelets and lymphocytes.
- Molecular basis of gamma-carboxylation. Role of the propeptide in the vitamin K-dependent proteins.
- Role of phosphatidylethanolamine in assembly and function of the factor IXa-factor VIIIa complex on membrane surfaces.
- Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent Platelets.
- Hepatic vitamin K-dependent carboxylation of blood-clotting proteins.
- PADGEM protein: a receptor that mediates the interaction of activated Platelets with neutrophils and monocytes.
- Structure of the propeptide of prothrombin containing the gamma-carboxylation recognition site determined by two-dimensional NMR spectroscopy.
- Localization of labile posttranslational modifications by electron capture dissociation: the case of gamma-carboxyglutamic acid.
- Conformation-specific monoclonal antibodies directed against the calcium-stabilized structure of human prothrombin.
- Recombinant blood clotting proteins for Hemophilia therapy.
- Leukocyte crosstalk at the vascular wall.
- Antibodies directed against a gamma-carboxyglutamic acid-rich region of bovine prothrombin. Preparation, isolation, and characterization.
- PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells.
- gamma-Carboxyglutamic acids 36 and 40 do not contribute to human factor IX function.
- P-selectin and E-selectin. Distinct but overlapping leukocyte ligand specificities.
- P-selectin, a granule membrane protein of Platelets and endothelial cells, follows the regulated secretory pathway in AtT-20 cells.
- Conformation-specific antibodies as probes of the gamma-carboxyglutamic acid-rich region of bovine prothrombin. Studies of metal-induced structural changes.
- Antifibrinolytic activity of apolipoprotein(a) in vivo: human apolipoprotein(a) transgenic mice are resistant to tissue plasminogen activator-mediated thrombolysis.
- Comparison of the native prothrombin antigen and the prothrombin time for monitoring oral anticoagulant therapy.
- PADGEM-dependent adhesion of Platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15).
- Metal binding properties of gamma-carboxyglutamic acid. Implications for the vitamin K-dependent blood Coagulation proteins.
- Expression of completely gamma-carboxylated recombinant human prothrombin.
- Amino acid sequence of a Platelet-binding human anti-DNA monoclonal autoantibody.
- Profactor IX: the propeptide inhibits binding to membrane surfaces and activation by factor XIa.
- A Platelet membrane protein expressed during Platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin-activated Platelets.
- Conformation-specific antibodies directed against the bovine prothrombin . calcium complex.
- Substitution of lanthanide ions for calcium ions in the activation of bovine prothrombin by activated factor X. High affinity metal-binding sites of prothrombin and th...
- PADGEM protein in human erythroleukemia cells.
- Sulfated glycolipids are the Platelet autoantigens for human Platelet-binding monoclonal anti-DNA autoantibodies.
- A Platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of Platelet activ...
- Structural transitions in bovine factor X associated with metal binding and zymogen activation. Studies using conformation-specific antibodies.
- Acquired vitamin K-dependent carboxylation deficiency in liver Disease.
- Prothrombin requires two sequential metal-dependent conformational transitions to bind phospholipid. Conformation-specific antibodies directed against the phospholipid...
- Computer-generated models of blood Coagulation factor Xa, factor IXa, and thrombin based upon structural homology with other serine proteases.
- Interaction of lanthanide ions with bovine factor X and their use in the affinity chromatography of the venom coagulant protein of Vipera russelli.
- Spectral changes in bovine factor X associated with activation by the venom coagulant protein of Vipera russelli.
- Monoclonal antibodies against human abnormal (des-gamma-carboxy)prothrombin specific for the calcium-free conformer of prothrombin.
- Molecular defect of prothrombin Barcelona. Substitution of cysteine for arginine at residue 273.
- Antibodies specific for bovine abnormal (des-gamma-carboxy-)prothrombin.
- Syndrome of acquired factor X deficiency and systemic amyloidosis in vivo studies of the metabolic fate of factor X.
- Recognition site directing vitamin K-dependent gamma-carboxylation resides on the propeptide of factor IX.
- Conformation-specific antibodies: approach to the study of the vitamin K-dependent blood Coagulation proteins.
- Molecular and cellular biology of blood Coagulation.
- Gamma-carboxyglutamic acid.
- Interactions of neutrophils and Coagulation proteins.
- Defects in vitamin K-dependent carboxylation associated with moxalactam treatment.
- Out on first.
- The molecular basis of blood Coagulation.
- Prothrombin fragment 1 X 2 X 3, a major product of prothrombin activation in human plasma.
- Mechanism of factor X deficiency in systemic amyloidosis.
- Localization of the metal-induced conformational transition of bovine prothrombin.
- Metal and phospholipid binding properties of partially carboxylated human prothrombin variants.
- In vivo thrombus formation.
- Homology of the NH2-terminal amino acid sequences of the heavy and light chains of human monoclonal lupus autoantibodies containing the dominant 16/6 idiotype.
- Activation of bovine factor X by the venom coagulant protein of Vipera russelli: complex formation of the activation fragments.
- Interactive computer surface graphics approach to study of the active site of bovine trypsin.
- Active site of bovine factor Xa. Characterization using substituted benzamidines as competitive inhibitors and affinity-labeling reagents.
- A computer-generated three-dimensional model of the B chain of bovine alpha-thrombin.
- Approaches to the study of prothrombin conformation and activation in biological fluids.
- PADGEM protein.
- Production of autoantibodies by human-human hybridomas.
- Coagulant protein of Russell's viper venom.
- Platelet binding properties of monoclonal lupus autoantibodies produced by human hybridomas.
- Circulating inhibitors of blood Coagulation associated with procainamide-induced lupus erythematosus.
- On the construction of computer models of proteins by the extension of crystallographic structures.
- Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins.
- Real time in vivo imaging of tissue factor-induced thrombus formation.
- Initial accumulation of Platelets during arterial thrombus formation in vivo is inhibited by elevation of basal cAMP levels.
- Peritoneal macrophages express both P-selectin and PSGL-1.
- Crystal structure of the calcium-stabilized human factor IX Gla domain bound to a conformation-specific anti-factor IX antibody.
- Role of Platelet P-selectin and microparticle PSGL-1 in thrombus formation.
- The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus.
- The metal-free and calcium-bound structures of a gamma-carboxyglutamic acid-containing contryphan from Conus marmoreus, glacontryphan-M.
Schools
Perelman School of Medicine University of Pennsylvania
University Penn Hospital
SUNY Syracuse
Conditions Treated
- Anemia
- Antiphospholipid Syndrome (APS)
- Coagulation Disorders (incl. Hemophilia)
- Deep Vein Thrombosis (DVT)
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Doctors Specialties
- Hematology
Accepted Insurances
Awards
- Regional Top Doctor
- Elected Member
Education
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SUNY Upstate Medical University -
University of Pennsylvania Health System -
Perelman School of Medicine at the University of Pennsylvania
Hospital
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Beth Israel Deaconess Medical Center
Drug Facts
| NPI NUMBER | 1134246903 | |
| NPPES Provider LastName | FURIE | |
| NPPES Provider FirstName | BRUCE | |
| NPPES Provider ZIPCode | 022155400 | |
| NPPES Provider State | MA | |
| Specialty Description | Hematology/Oncology | |
| Total Claim Count | 14.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1134246903 |
| Last Name Of The Provider | FURIE |
| First Name Of The Provider | BRUCE |
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