Associate Professor, Internal Medicine, Washington University School of Medicine
Gastroenterology
Dr. Brian K. Dieckgraefe, MD
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Brian Dieckgraefe works in the field of Gastroenterology. He researched medicine at Washington University School of Medicine in St. Louis. Brian Dieckgraefe is also a published doctor. He has 48 publication published. The most recent publication is: Epithelial injury induces egr-1 and fos expression by a pathway involving protein kinase C and ERK.
Publications
- Reg4-induced mitogenesis involves Akt-GSK3β-β-Catenin-TCF-4 signaling in human Colorectal cancer.
- Toll-like receptor-7 ligand imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium sulfate-induced acute Colitis.
- RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic Cancer cells.
- NOD2 status and human ileal gene expression.
- Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues.
- Reg IV regulates normal intestinal and Colorectal cancer cell susceptibility to radiation-induced apoptosis.
- Loss of p21Waf1/Cip1/Sdi1 enhances Intestinal stem cell survival following radiation injury.
- REG1A expression is a prognostic marker in Colorectal cancer and associated with peritoneal carcinomatosis.
- Knockdown of RNA binding protein musashi-1 leads to tumor regression in vivo.
- Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms.
- Diphenyl difluoroketone: a curcumin derivative with potent in vivo antiCancer activity.
- Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental Colitis.
- Characterization of cecal gene expression in a differentially susceptible mouse model of bacterial-induced inflammatory bowel Disease.
- Functional antagonism between RNA binding proteins HuR and CUGBP2 determines the fate of COX-2 mRNA translation.
- Dysregulation of Reg gene expression occurs early in gastroIntestinal tumorigenesis and regulates anti-apoptotic genes.
- Growth factors as treatment options for Intestinal inflammation.
- Molecular biology of the small intestine.
- Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas.
- PEGylated murine Granulocyte-macrophage colony-stimulating factor: production, purification, and characterization.
- What does football have in common with Crohn's Disease? The best "defense-in" is a good offense.
- Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice.
- Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage.
- CUGBP2 plays a critical role in apoptosis of breast Cancer cells in response to genotoxic injury.
- Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2.
- Expression of the regenerating gene family in inflammatory bowel Disease mucosa: Reg Ialpha upregulation, processing, and antiapoptotic activity.
- Application of genome-wide gene expression profiling by high-density DNA arrays to the treatment and study of inflammatory bowel Disease.
- Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV.
- Analysis of mucosal gene expression in inflammatory bowel Disease by parallel oligonucleotide arrays.
- Is Crohn's Disease an immunodeficiency? A hypothesis suggesting possible early events in the pathogenesis of Crohn's Disease.
- Angiomyolipoma of the large intestine: report of a case.
- Epithelial injury induces egr-1 and fos expression by a pathway involving protein kinase C and ERK.
- ERK and p38 MAP kinase pathways are mediators of Intestinal epithelial wound-induced signal transduction.
- Immunolocalization of alpha-integrin subunits and extracellular matrix components during human colonic organogenesis.
- Isolation and structural characterization of a cDNA clone encoding rat gastric intrinsic factor.
- Developmental regulation of rat intrinsic factor mRNA.
- Association of glycogen storage Disease 1b and Crohn Disease: results of a North American survey.
- Isolation and characterization of rabbit single chain antibodies to human Reg Ialpha protein.
- Treatment of active Crohn''s Disease with recombinant human granulocyte-macrophage colony-stimulating factor.
- An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn''s Disease.
- Expression of a novel regenerating gene product, Reg IV, by high density fermentation in Pichia pastoris: production, purification, and characterization.
- Sargramostim for active Crohn''s Disease.
- Azoxymethane protects Intestinal stem cells and reduces crypt epithelial mitosis through a COX-1-dependent mechanism.
- Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis.
- Expression of the genes dual oxidase 2, lipocalin 2 and regenerating islet-derived 1 alpha in Crohn''s Disease.
- Translation regulatory factor RBM3 is a proto-oncogene that prevents mitotic catastrophe.
- Clostridium difficile-associated Disease in allogeneic hematopoietic stem-cell transplant recipients: risk associations, protective associations, and outcomes.
- Dextran sodium sulfate inhibition of real-time polymerase chain reaction amplification: a poly-A purification solution.
Schools
Washington Center School of Medicine
Barnes Jewish Hospital
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
Conditions Treated
- Anemia
- Cholecystitis and Gallstones
- Colorectal Cancer
- Crohn's Disease (Regional Enteritis)
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Doctors Specialties
- Gastroenterology
Accepted Insurances
Education
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Washington University - Barnes-Jewish Hospital -
Washington University School of Medicine in St. Louis
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