Professor of Pediatrics, Kosair Chair Pediatric Heart Research, Vice Chair, Pediatric Research, University of Louisville Physicians
Pediatric Cardiology
Dr. Bradley B. Keller, MD
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Bradley B. Keller is an expert in the field of Pediatric Cardiology. He went to medical school at Penn State College of Medicine. Bradley Keller has written publications. He has 93 publications published with PubMed. The lastest paper is: 'Heart rate and flow velocity variability as determined from umbilical Doppler velocimetry at 10-20 weeks of gestation.'
Publications
- Effects of physiologic mechanical stimulation on embryonic chick cardiomyocytes using a microfluidic cardiac cell culture model.
- Challenges in implementing a pediatric cardiovascular home telehealth project.
- Simulation of dilated Heart failure with continuous flow circulatory support.
- Gene expression profiles in engineered cardiac tissues respond to mechanical loading and inhibition of tyrosine kinases.
- Cardiac cell culture model as a left ventricle mimic for cardiac tissue generation.
- Maternal hypoxia and caffeine exposure depress fetal cardiovascular function during primary organogenesis.
- Human Skeletal Muscle Cells With a Slow Adhesion Rate After Isolation and an Enhanced Stress Resistance Improve Function of Ischemic Hearts.
- Engineered fetal cardiac graft preserves its cardiomyocyte proliferation within postinfarcted myocardium and sustains cardiac function.
- Placental Inflammation and Fetal Hemodynamics in a Rat Model of Chorioamnionitis.
- A three-dimensional gel bioreactor for assessment of cardiomyocyte induction in skeletal muscle-derived stem cells.
- Optimization of inflow waveform phase-difference for minimized total cavoPulmonary power loss.
- The learning curve for a fetal cardiac intervention team.
- Pulsatile in vitro simulation of the pediatric univentricular circulation for evaluation of cardioPulmonary assist scenarios.
- Aortic arch morphogenesis and flow modeling in the chick embryo.
- Engineered early embryonic cardiac tissue increases cardiomyocyte proliferation by cyclic mechanical stretch via p38-MAP kinase phosphorylation.
- Naive rat amnion-derived cell transplantation improved left ventricular function and reduced myocardial scar of postinfarcted Heart.
- Sex of muscle stem cells does not influence potency for cardiac cell therapy.
- Antioxidant levels represent a major determinant in the regenerative capacity of muscle stem cells.
- Myogenic endothelial cells purified from human skeletal muscle improve cardiac function after transplantation into infarcted myocardium.
- Modest maternal caffeine exposure affects developing embryonic cardiovascular function and growth.
- The role of cardiac troponin T quantity and function in cardiac development and dilated Cardiomyopathy.
- A relationship between vascular endothelial growth factor, angiogenesis, and cardiac repair after muscle stem cell transplantation into ischemic Hearts.
- An elastic, biodegradable cardiac patch induces contractile smooth muscle and improves cardiac remodeling and function in subacute myocardial infarction.
- New insights into the developmental biomechanics of the atrioventricular Valves.
- Cardiovascular developmental insights from embryos.
- Engineered early embryonic cardiac tissue retains proliferative and contractile properties of developing embryonic myocardium.
- Increased arterial load alters Aortic structural and functional properties during embryogenesis.
- Preterminal gasping during hypoxic cardiac arrest increases cardiac function in immature rats.
- Impact of hypoxia on early chick embryo growth and cardiovascular function.
- The PediaFlow pediatric ventricular assist device.
- Differential myocardial infarct repair with muscle stem cells compared to myoblasts.
- Developmental structure-function insights from Tbx5(del/+) mouse model of Holt-Oram syndrome.
- Three-dimensional myofiber architecture of the embryonic left ventricle during normal development and altered mechanical loads.
- Usefulness of plasma B-type natriuretic peptide to identify ventricular dysfunction in pediatric and adult patients with congenital heart Disease.
- Quality of life and social outcomes in adults with congenital heart Disease living in rural areas of Kentucky.
- Differential cardiovascular regulatory activities of the alpha 1B- and alpha 1D-adrenoceptor subtypes.
- Microtubule involvement in the adaptation to altered mechanical load in developing chick myocardium.
- Cellular changes in experimental left Heart hypoplasia.
- Regional passive ventricular stress-strain relations during development of altered loads in chick embryo.
- Dorsal Aortic impedance in stage 24 chick embryo following acute changes in circulating blood volume.
- In vivo assessment of embryonic cardiovascular dimensions and function in day-10.5 to -14.5 mouse embryos.
- Nitroprusside selectively reduces ventricular preload in the stage 21 chick embryo.
- Ventricular-vascular uncoupling by acute conotruncal occlusion in the stage 21 chick embryo.
- Diastolic filling characteristics in the stage 12 to 27 chick embryo ventricle.
- End-systolic myocardial stiffness is a load-independent index of contractility in stage 24 chick embryonic Heart.
- Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse Heart.
- Influence of acute alterations in cycle length on ventricular function in chick embryos.
- Passive stress-strain measurements in the stage-16 and stage-18 embryonic chick Heart.
- Relationship of simultaneous Atrial and ventricular pressures in stage 16-27 chick embryos.
- Effects of mechanical interaction between two rabbit cardiac muscles connected in parallel.
- Hemodynamic response to anesthesia in pregnant and nonpregnant ICR mice.
- Assessment of fetal heart rate variability and velocity variability by Doppler velocimetry of the descending Aorta at 10-20 weeks of gestation.
- Cardiac mechanics in the stage-16 chick embryo.
- Epicardial strains in embryonic chick ventricle at stages 16 through 24.
- Linearity of pulsatile pressure-flow relations in the embryonic chick vascular system.
- Developmental changes in flow-wave propagation velocity in embryonic chick vascular system.
- Fetal Heart rate and umbilical artery velocity variability in pregnancies complicated by insulin-dependent diabetes mellitus.
- Do Heart rate and velocity variability derived from umbilical artery velocity waveforms change prior to clinical pregnancy-induced hypertension?
- [Contraction-relaxation dynamics and mechanical restitution in the developing myocardium of the chick embryo].
- Lumped parameter estimation for the embryonic chick vascular system: a time-domain approach using MLAB.
- Characterization of embryonic Aortic impedance with lumped parameter models.
- [The role of intra- and extracellular calcium sources in the rhythmic inotropic regulation of isometric contractions in the chick embryo myocardium].
- Umbilical arterial blood flow in the mouse embryo during development and following acutely increased Heart rate.
- Dynamic, electronically switchable surfaces for membrane protein microarrays.
- [Experimental-theoretical study of the force-interval relationship in the developing chicken myocardium].
- Characterization of passive embryonic myocardium by quasi-linear viscoelasticity theory.
- Umbilical artery waveform analysis based on maximum, mean and mode velocity in early human pregnancy.
- Heart rate and flow velocity variability as determined from umbilical Doppler velocimetry at 10-20 weeks of gestation.
- Power spectrum analysis of Heart rate and blood flow velocity variability measured in the umbilical and uterine arteries in early pregnancy: a comparative study.
- Systematic determination of the packaging limit of lentiviral vectors.
- Homozygous mutation of MYBPC3 associated with severe infantile hypertrophic Cardiomyopathy at high frequency among the Amish.
- Thresholds for premature ventricular contractions in frog Hearts exposed to lithotripter fields.
- Increased mortality after coronary artery bypass graft surgery is associated with increased levels of postoperative creatine kinase-myocardial band isoenzyme release: ...
- Incidence of childhood malignancies in the vicinity of west German nuclear power plants.
- Effects of pulsed ultrasound on the frog heart: I. Thresholds for changes in cardiac rhythm and Aortic pressure.
- Critical transitions in early embryonic Aortic arch patterning and hemodynamics.
- Investigating developmental cardiovascular biomechanics and the origins of Congenital heart defects.
- Human embryonic stem cell-derived hematoendothelial progenitors engraft chicken embryos.
- Morphological and mechanical characteristics of the reconstructed rat abdominal wall following use of a wet electrospun biodegradable polyurethane elastomer scaffold.
- Computer-assisted navigation applied to fetal cardiac intervention.
- Hemodynamic vulnerability to acute hypoxia in day 10.5-16.5 murine embryos.
- Arterial hemodynamics and mechanical properties after circulatory intervention in the chick embryo.
- Cellular antioxidant levels influence muscle stem cell therapy.
- Correlation of ventricular area, perimeter, and conotruncal diameter with ventricular mass and function in the chick embryo from stages 12 to 24.
- Analysis of dynamic Atrial dimension and function during early cardiac development in the chick embryo.
- Maturation of end-systolic stress-strain relations in chick embryonic myocardium.
- Right and left ventricular wall deformation patterns in normal and left Heart hypoplasia chick embryos.
- Effect of Atrial natriuretic peptide on diastolic filling in the stage 21 chick embryo.
- Ventricular pressure-area loop characteristics in the stage 16 to 24 chick embryo.
- In vitro hemodynamic investigation of the embryonic Aortic arch at late gestation.
- Towards the development of a pediatric ventricular assist device.
- Residual strain in the ventricle of the stage 16-24 chick embryo.
Schools
Pennsylvania State University College Of Medicine
Johns Hopkins Hospital
Strong Memorial Hospital
Procedures Preformed
- Cardiac Imaging
- Tilt Testing or Cardiac Event Monitors
Conditions Treated
- Aortic Valve Disease
- Arrhythmias (incl. Atrial Fibrillation)
- Cardiomegaly
- Cardiomyopathy
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Doctors Specialties
- Pediatric Cardiology
Accepted Insurances
Education
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University of Rochester -
Johns Hopkins University -
Penn State College of Medicine
Hospital
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University of Louisville Hospital -
Kosair Children's Hospital
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