Physician
Family Medicine
Dr. Betsy J. Longenecker, MD
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Betsy Longenecker works in the field of Family Medicine. He went to University of Kansas School of Medicine. Betsy Longenecker is also a published MD. He has 101 publication published. The most recent publication is: Evidence of a cellular immune response against sialyl-Tn in breast and ovarian cancer patients after high-dose chemotherapy, stem cell rescue, and immunization with Th...
Publications
- Glycosylations versus conformational preferences of cancer associated mucin core.
- Association of MUC-1 and SPGL-1 with low-density microdomain in T-lymphocytes: a preliminary note.
- Anti-MUC-1 immunoliposomal doxorubicin in the treatment of murine models of metastatic breast cancer.
- A low-level expression of human MUC1 mucin enhances lethality of murine tumor cells.
- Clinical outcome of breast and ovarian cancer patients treated with high-dose chemotherapy, autologous stem cell rescue and THERATOPE STn-KLH cancer vaccine.
- Anti-T antibodies and peanut-agglutinin-binding glycoproteins in sera of patients with gastric cancer.
- Vaccines prepared with sialyl-Tn and sialyl-Tn trimers using the 4-(4-maleimidomethyl)cyclohexane-1-carboxyl hydrazide linker group result in optimal antibody titers a...
- Evidence of a cellular immune response against sialyl-Tn in breast and ovarian cancer patients after high-dose chemotherapy, stem cell rescue, and immunization with Th...
- Rapid induction of primary human CD4+ and CD8+ T cell responses against cancer-associated MUC1 peptide epitopes.
- MUC1 synthetic peptide inhibition of intercellular adhesion molecule-1 and MUC1 binding requires six tandem repeats.
- The anti-MUC1 monoclonal antibody BCP8 can be used to isolate and identify putative major histocompatibility complex class I associated amino acid sequences.
- The biological role of mucins in cellular interactions and immune regulation: prospects for cancer immunotherapy.
- Expression of MUC1 mucin on activated human T cells: implications for a role of MUC1 in normal immune regulation.
- Liposomal formulations of synthetic MUC1 peptides: effects of encapsulation versus surface display of peptides on immune responses.
- Anti-MUC1 class I restricted CTLs in metastatic breast cancer patients immunized with a synthetic MUC1 peptide.
- Different modes of sialyl-Tn expression during malignant transformation of human colonic mucosa.
- Immunogenicity and antitumor activity of a liposomal MUC1 peptide-based vaccine.
- Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2.
- Analysis of the role of type 1 core O-glycans in the binding of anti-MUC1 antibodies by cytofluorometry and synthetic peptide/glycopeptide binding inhibition studies.
- Specificities of anti-sialyl-Tn and anti-Tn monoclonal antibodies generated using novel clustered synthetic glycopeptide epitopes.
- Prognostic significance of preimmunotherapy serum CA27.29 (MUC-1) mucin level after active specific immunotherapy of metastatic adenocarcinoma patients.
- Specificity analysis of murine monoclonal antibodies reactive with Tn, sialylated Tn, T, and monosialylated (2-->6) T antigens.
- A randomised phase II study of sialyl-Tn and DETOX-B adjuvant with or without cyclophosphamide pretreatment for the active specific immunotherapy of breast cancer.
- Enhancing the effect of THERATOPE STn-KLH cancer vaccine in patients with metastatic breast cancer by pretreatment with low-dose intravenous cyclophosphamide.
- CD30 expression on human CD8+ T cells isolated from peripheral blood lymphocytes of normal donors.
- Antibodies against mucin-associated sialyl-Tn epitopes correlate with survival of metastatic adenocarcinoma patients undergoing active specific immunotherapy with synt...
- The breast mucin MUCI as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer.
- In vitro induction of MUC-1 peptide-specific type 1 T lymphocyte and cytotoxic T lymphocyte responses from healthy multiparous donors.
- Pre-immunotherapy serum CA27.29 (MUC-1) mucin level and CD69+ lymphocytes correlate with effects of Theratope sialyl-Tn-KLH cancer vaccine in active specific immunothe...
- Structurally defined synthetic cancer vaccines: analysis of structure, glycosylation and recognition of cancer associated mucin, MUC-1 derived peptides.
- Immunization of breast cancer patients using a synthetic sialyl-Tn glycoconjugate plus Detox adjuvant.
- GM2-KLH conjugate vaccine: increased immunogenicity in melanoma patients after administration with immunological adjuvant QS-21.
- Immune responses of mice and human breast cancer patients following immunization with synthetic sialyl-Tn conjugated to KLH plus detox adjuvant.
- Monoclonal antibodies directed against a widespread oncofetal antigen: the alpha-fetoprotein receptor.
- Immune sera and monoclonal antibodies define two configurations for the sialyl Tn tumor antigen.
- Development of active specific immunotherapeutic agents based on cancer-associated mucins.
- CD69+ and HLA-DR+ activation antigens on peripheral blood lymphocyte populations in metastatic breast and ovarian cancer patients: correlations with survival following...
- Does pregnancy immunize against breast cancer?
- Specificity of the IgG response in mice and human breast cancer patients following immunization against synthetic sialyl-Tn, an epitope with possible functional signif...
- New possibilities for cancer therapy with advances in cancer immunology.
- Active specific immunotherapy against adenocarcinomas.
- Detection of a cell-surface antigen correlated with organ-specific metastasis.
- Selection for virulence and organ-specific metastasis of herpesvirus-transformed lymphoma cells.
- Clonal variation and functional correlation of organ-specific metastasis and an organ-specific metastasis-associated antigen.
- "Natural" antibodies to chicken MHC antigens are present in mice, rats, humans, alligators and allogeneic chickens.
- Restricted expression of an MHC alloantigen in cells of the erythroid series: a specific marker for erythroid differentiation.
- Nomenclature for chicken major histocompatibility (B) complex.
- Radioimmunotechnology for cancer diagnosis and treatment.
- Major histocompatibility complex of chickens: genes, antigens, differential features, and special contributions to our knowledge of the advantages of polymorphism of c...
- Immune response of the mouse to gram-negative bacterial outer membrane extracts as assessed with monoclonal antibodies.
- Antibody-mediated cellular cytotoxicity against Raji cells ADCC(Raji): evaluation of false positives in the detection of circulating immune complexes by Raji-cell assay.
- A new model for leukemia-lymphoma metastasis: differential growth and rejection of murine lymphoid-leukemia cell lines in the bone marrow.
- Biochemical characterization of human carcinoma surface antigen associated with protein kinase activity.
- Human tumor cell membrane glycoprotein associated with protein kinase activity.
- Radiolabelled peanut lectin for the scintigraphic detection of cancer.
- Homing receptors as functional markers for classification, prognosis, and therapy of leukemias and lymphomas.
- Correlation of erythrocytic peripheral blood chimaerism and putative bone marrow precursors bearing erythroid differentiation (B-G) antigens using monoclonal antibodie...
- A monoclonal antibody detecting a 39,000 m.w. molecule that is present on B lymphocytes and chronic lymphocytic leukemia cells but is rare on acute lymphocytic leukemi...
- Organ specific metastasis with special reference to avian systems.
- Genetic resistance to herpesvirus-induced lymphoma at the level of the target cell determined by the thymic microenvironment.
- Structure and properties of the major histocompatibility complex of the chicken. Speculations on the advantages and evolution of polymorphism.
- Monoclonal antibody against a cryptic carbohydrate antigen of murine and human lymphocytes. I. Antigen expression in non-cryptic or unsubstituted form on certain murin...
- Preparation and properties of monoclonal antibodies against cell surface polymorphic or allelic determinants: their use in blood typing and the study of cell different...
- Preference of the early murine immune response for polymorphic determinants on human lymphoid-leukemia cells and the potential use of monoclonal antibodies to these de...
- A monoclonal antibody specific for the Thomsen-Friedenreich cryptic T antigen.
- Antigenic heterogeneity of human colorectal cancer cell lines analyzed by a panel of monoclonal antibodies. I. Heterogeneous expression of Ia-like and HLA-like antigen...
- The high background immune reactivity of mice to polymorphic determinants on xenogeneic erythrocytes: theoretical and practical implications.
- A strong, specific response of mice to serotype-specific antigenic determinants of Neisseria meningitidis, analyzed with mouse monoclonal antibodies.
- Nomenclature for chicken MHC (B) antigens defined by monoclonal antibodies.
- Alteration of apparent specificity of monoclonal (hybridoma) antibodies recognizing polymorphic histocompatibility and blood group determinants.
- Tolerance and autoimmunity to erythroid differentiation (B-G) major histocompatibility complex alloantigens of the chicken.
- A monoclonal antibody against chicken MHC class I (B-F) antigens.
- In vivo localization of radioiodinated peanut lectin in a murine TA3/Ha mammary carcinoma model.
- Radioimmunodetection of murine mammary adenocarcinoma (TA3/Ha) lung and liver metastases with radioiodinated PNA.
- Radioiodinated peanut lectin: clinical use as a tumour-imaging agent and potential use in assessing renal-tubular function.
- Renal tubular receptor imaging with iodine-131-labeled peanut lectin: pharmacokinetics and renal clearance mechanism in animals.
- Monoclonal antibodies and synthetic tumor-associated glycoconjugates in the study of the expression of Thomsen-Friedenreich-like and Tn-like antigens on human cancers.
- Characterization of gp39, a B-lymphocyte associated differentiation antigen which is also present on granulocytes and macrophages.
- Comparative radiolabeling and distribution of a tumour-directed monoclonal antibody.
- Further evidence for the existence of ''homing'' receptors on murine leukemia cells which mediate adherence to normal bone marrow stromal cells.
- Experimental application of target-specific immunoconjugates containing daunomycin as the cytocidal component.
- Comparison of the 40 kDa hematopoietic cell antigens bound by monoclonal antibodies IV.3, 41H.16 and KB61.
- Immunohistochemical staining and radionuclide imaging of canine tumors, using a monoclonal antibody recognizing a synthetic carbohydrate antigen.
- A novel marker for basal (stem) cells of mammalian stratified squamous epithelia and squamous cell carcinomas.
- T cell recognition of a tumor-associated glycoprotein and its synthetic carbohydrate epitopes: stimulation of anticancer T cell immunity in vivo.
- A molecular approach to immunoscintigraphy: a study of the T-antigen conformation on the surface of tumors.
- Murine T-cell clones specific for chicken erythrocyte alloantigens.
- A phenyl-beta-galactoside-specific monoclonal antibody reactive with murine and rat NK cells.
- Active specific immunotherapy of a murine mammary adenocarcinoma using a synthetic tumor-associated glycoconjugate.
- Effective drug-antibody targeting using a novel monoclonal antibody against the proliferative compartment of mammalian squamous carcinomas.
- Analysis of human tumor associated Thomsen-Friedenreich antigen.
- Clinical evaluation of a new two-site assay for CA125 antigen.
- Possible utility of serum determinations of CA 125 and CA 27.29 in breast cancer management.
- Specific immunosuppressive activity of epiglycanin, a mucin-like glycoprotein secreted by a murine mammary adenocarcinoma (TA3-HA).
- Clinical significance of the Thomsen-Friedenreich antigen.
- Tumor cell surface alpha 4 beta 1 integrin mediates adhesion to vascular endothelium: demonstration of an interaction with the N-terminal domains of INCAM-110/VCAM-1.
- Tumour markers in the detection of opisthorchiasis-associated cholangiocarcinoma.
- Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells.
- Expression of genetic resistance to an oncogenic herpesvirus at the target cell level.
- Genetic control of resistance to Marek''s disease.
Schools
University of Kansas School of Medicine
Doctors Specialties
- Family Medicine
Accepted Insurances
- Choice Plus POS II
- Pathway X Bronze Direct CACA IN HIX
- Anthem Blue Cross Blue Shield PPO
- Blue Card PPO
- Cofinity PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Education
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Banner Good Samaritan Medical Center -
University of Kansas School of Medicine
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