Professor, Internal Medicine, Yale University School of Medicine

Hematology

Bernard Forget works in the field of Hematology. He over the years received 2 awards: "Elected Member" and "Whos Who in Medicine and Healthcare". Bernard Forget is a published doctor. He published 99 publications, including: 'Molecular basis of hereditary persistence of fetal hemoglobin.'

Publications

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• Classification of the disorders of hemoglobin.
• Massive splenic infarction in an adolescent with hemoglobin S-HPFH.
• A de novo band 3 mutation in hereditary spherocytosis.
• Progress in understanding the hemoglobin switch.
• Preface. Thalassemia.
• Downstream targets of HOXB4 in a cell line model of primitive hematopoietic progenitor cells.
• Ankyrin-linked hereditary spherocytosis in an African-American kindred.
• De novo and acquired forms of alpha thalassemia.
• Expression of Pitx2 in stromal cells is required for normal hematopoiesis.
• A novel splicing mutation of the alpha-spectrin gene in the original hereditary pyropoikilocytosis kindred.
• Sequences downstream of the erythroid promoter are required for high level expression of the human alpha-spectrin gene.
• Mutation of a highly conserved isoleucine disrupts hydrophobic interactions in the alpha beta spectrin self-association binding site.
• Marrow stem cells shift gene expression and engraftment phenotype with cell cycle transit.
• A novel mutation in the erythropoietin receptor gene is associated with familial erythrocytosis.
• Studies of globin chain synthesis and globin mRNA content in a patient homozygous for hemoglobin Lepore.
• Nucleotide sequence of human beta globin messenger RNA.
• Gene mapping by fluorescent in situ hybridization.
• Cotransfer of circular and linear prokaryotic and eukaryotic DNA sequences into mouse cells.
• Structure and organization of the human globin genes.
• The aminoacyl-tRNA population of human reticulocytes.
• The structure of hemoglobin Indianapolis [beta112(G14) arginine]. An unstable variant detectable only by isotopic labeling.
• Cloning and nucleotide sequence analysis of human embryonic zeta-globin cDNA.
• The biosynthesis of hemoglobin.
• Use of globin cDNA as a hybridization probe for globin mRNA.
• Embryonic-fetal erythroid characteristics of a human leukemic cell line.
• Physicochemical measurement of the base composition of mRNA-related sequences of the human alpha and beta globin genes.
• The thalassemias: molecular mechanisms of human genetic disease.
• Potentiation of human erythropoiesis in vitro by thyroid hormone.
• Molecular pathology of the thalassemias.
• Assignment of the gene for beta-spectrin (SPTB) to chromosome 14q23----q24.2 by in situ hybridization.
• Heterogeneity in the molecular basis of hereditary persistence of fetal haemoglobin.
• Synthesis of DNA complementary to separated human alpha and beta globin messenger RNAs.
• The molecular genetics of the thalassemia syndromes.
• Variability in the amount of beta-globin mRNA in beta0 thalassemia.
• beta-globin mRNA in Ferrara betao-thalassaemia.
• Molecular genetics of human hemoglobin synthesis.
• Prenatal diagnosis of homozygous alpha-thalassemia.
• Hemoglobin Indianapolis (beta 112[G14] arginine). An unstable beta-chain variant producing the phenotype of severe beta-thalassemia.
• The structure of human globin messenger RNA: functional, genetic, and evolutionary implications.
• Globin chain electrophoresis for prenatal diagnosis of beta thalassemia.
• Prenatal diagnosis of hemoglobinopathies: the New England approach.
• Analysis of beta-globin genes in beta 0 thalassemia.
• Heterogeneity of messenger RNA defects in the thalassemia syndromes.
• Quantitative deficiency of chain-specific globin messenger ribonucleic acids in the thalassemia syndromes.
• The molecular basis of thalassemia.
• Absence of messenger RNA for beta globin chain in beta(0) thalassaemia.
• Three RFLPs are detected by an alpha spectrin genomic clone.
• Pitfalls of genetic testing.
• Hemoglobin synthesis in human BFU-E and CFU-E-derived erythroid colonies.
• Prenatal diagnosis of classic hemophilia.
• Induction of erythropoietic colonies in a human chronic myelogenous leukemia cell line.
• Hemin control of heme biosynthesis and catabolism in a human leukemia cell line.
• The thalassemia syndromes: models for the molecular analysis of human disease.
• Erythroid cell differentiation.
• Cloning of a portion of the chromosomal gene for human erythrocyte alpha-spectrin by using a synthetic gene fragment.
• Independence of dysplastic nevi from total nevi in determining risk for nonfamilial melanoma.
• Nucleotide sequence of KB cell 5S RNA.
• Low molecular weight RNA components from KB cells.
• RNA of low molecular weight in KB cells infected with adenovirus type 2.
• Molecular basis of hereditary persistence of fetal hemoglobin.
• YAC transgenes: bigger is probably better.
• Beta-thalassemia resulting from a single nucleotide substitution in an acceptor splice site.
• Defective processing of beta mRNA in different forms of beta +-thalassemia.
• Molecular studies of genetic disorders affecting the expression of the human beta-globin gene: a model system for the analysis of inborn errors of metabolism.
• Clinical and molecular correlations in the sickle/beta+-thalassemia syndrome.
• An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells.
• New amber mutation in a beta-thalassemic gene with nonmeasurable levels of mutant messenger RNA in vivo.
• Two elliptocytogenic alpha I/74 variants of the spectrin alpha I domain. Spectrin Culoz (GGT----GTT; alpha I 40 Gly----Val) and spectrin Lyon (CTT----TTT; alpha I 43 L...
• Identification of a beta-thalassemia mutation associated with a novel haplotype of RFLPs.
• Absence of functional messenger RNA activity for beta globin chain synthesis in beta 0-thalassemia.
• Beta-thalassemia due to two novel nucleotide substitutions in consensus acceptor splice sequences of the beta-globin gene.
• A novel basis for delta beta-thalassemia in a Chinese family.
• Globin messenger RNA in hemoglobin H disease.
• Gamma-beta thalassemia: a cause of hemolytic disease of the newborn.
• Beta globin messenger RNA content of bone marrow erythroblasts in heterozygous beta-thalassemia.
• Intranuclear defect in beta-globin mRNA accumulation due to a premature translation termination codon.
• Point mutations or polymorphisms? A sequence analysis of the enhancer 3' to the A gamma-globin gene.
• Erythroid and nonerythroid spectrins.
• Different 3' end points of deletions causing delta beta-thalassemia and hereditary persistence of fetal hemoglobin: implications for the control of gamma-globin gene e...
• The pathophysiology and molecular genetics of beta thalassemia.
• Nucleotide sequence of 3'' untranslated portion of human alpha globin mRNA.
• Imbalanced globin chain synthesis in cultured erythroid progenitor cells from thalassemic bone marrow and peripheral blood.
• A conserved gene 3' to the HPFH-1 deletion breakpoint may have an effect on fetal globin gene expression in HPFH-1.
• Nucleotide sequences of the 3''-terminal untranslated region of messenger RNA for human beta globin chain.
• Sequences of human repetitive DNA, non-alpha-globin genes, and major histocompatibility locus genes.
• The nucleotide sequence of ribosomal 5 S ribonucleic acid from KB cells.
• Oligonucleotides produced by digestion of KB cell ribosomal 5 S ribonucleic acid with specific nucleases.
• Human beta-globin messenger RNA. II. nucleotide sequences derived from 125I-labeled globin messenger RNA.
• Reverse transcription and direct amplification of cellular RNA transcripts by Taq polymerase.
• Nucleotide sequence of human G gamma globin messenger RNA.
• Human globin messenger RNA: importance of cloning for structural analysis.
• RNA polymerase III transcriptional units are interspersed among human non-alpha-globin genes.
• Insertion of synthetic copies of human globin genes into bacterial plasmids.
• Nucleotide sequences of human globin messenger RNA.
• Complete nucleotide sequence of the human delta-globin gene.
• Short interspersed repetitive DNA elements in eucaryotes: transposable DNA elements generated by reverse transcription of RNA pol III transcripts?
• Interspersed repetitive DNA sequences of the human genome: are they transposons?
• [Research on genetic abnormality in the hemolytic form of hereditary elliptocytosis with homozygosity for the spectrin alpha I/74 variant].

Schools

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• McGill University Faculty of Medicine

• Massachusetts General Hospital

• Peter Bent Brigham HospChldns Hospital

Doctors Specialties

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• Hematology

Accepted Insurances

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Awards

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• Elected Member
• Whos Who in Medicine and Healthcare

Education

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• Boston Children's Hospital
• Massachusetts General Hospital
• McGill University Faculty of Medicine

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