Professor, Medicine, Stony Brook University SOM

Gastroenterology

Basil Rigas practices Gastroenterology. Basil Rigas is a published physician. He published 99 publications, including: 'Cytologically normal cells from neoplastic cervical samples display extensive structural abnormalities on IR spectroscopy: implications for tumor biology.'

Publications

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• The novel agent phospho-glycerol-ibuprofen-amide (MDC-330) inhibits glioblastoma growth in mice: an effect mediated by cyclin D1.
• The evolving role of NSAIDs in colon Cancer prevention: A cause for optimism.
• Phospho-NSAIDs Have Enhanced Efficacy in Mice Lacking Plasma Carboxylesterase: Implications for their Clinical Pharmacology.
• Pegylation improves the pharmacokinetics and bioavailability of Small-molecule drugs hydrolyzable by esterases: a study of phospho-Ibuprofen.
• A novel ibuprofen derivative with anti-lung Cancer properties: Synthesis, formulation, pharmacokinetic and efficacy studies.
• The in vitro metabolism of phospho-sulindac amide, a novel potential antiCancer agent.
• Phospho-sulindac inhibits pancreatic Cancer growth: NFATc1 as a drug resistance candidate.
• A Novel Ras Inhibitor (MDC-1016) Reduces Human Pancreatic Tumor Growth in Mice.
• Curcumin enhances the lung Cancer chemopreventive efficacy of phospho-sulindac by improving its pharmacokinetics.
• Aerosol administration of phospho-sulindac inhibits lung tumorigenesis.
• Topically Applied Phospho-Sulindac Hydrogel is Efficacious and Safe in the Treatment of Experimental Arthritis in Rats.
• Comparative in vitro metabolism of phospho-tyrosol-indomethacin by mice, rats and humans.
• The antiCancer effect of phospho-tyrosol-indomethacin (MPI 621), a novel phospho-derivative of indomethacin: In vitro and in vivo studies.
• Platinum folate nanoparticles toxicity: Cancer vs. normal cells.
• FT-IR microspectroscopy of mouse colon tissues: insight into the chemistry of carcinogenesis and diagnostic potential.
• MC-12, an Annexin A1-Based Peptide, Is Effective in the Treatment of Experimental Colitis.
• In Vitro and In Vivo Metabolic Studies of Phospho-aspirin (MDC-22).
• Phospho-Sulindac (OXT-328) Inhibits the Growth of Human Lung Cancer Xenografts in Mice: Enhanced Efficacy and Mitochondria Targeting by its Formulation in Solid Lipid ...
• Preclinical predictors of antiCancer drug efficacy: critical assessment with emphasis on whether nanomolar potency should be required of candidate agents.
• Phospho-ibuprofen (MDC-917) incorporated in nanocarriers: anti-Cancer activity in vitro and in vivo.
• Sterically stabilized liposomes incorporating the novel antiCancer agent phospho-ibuprofen (MDC-917): preparation, characterization, and in vitro/in vivo evaluation.
• Phosphosulindac (OXT-328) Selectively Targets Breast Cancer Stem Cells In vitro and in Human Breast Cancer Xenografts.
• Regioselective oxidation of phospho-NSAIDs by human cytochrome P450 and flavin monooxygenase isoforms: Implications for their pharmacokinetic properties and safety.
• Repurposing the antipsychotic trifluoperazine as an antimetastasis agent.
• Phospho-Aspirin-2 (MDC-22) Inhibits Estrogen Receptor Positive Breast Cancer Growth Both In Vitro and In Vivo by a Redox-Dependent Effect.
• Phospho-aspirin (MDC-22) inhibits breast Cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress.
• Targeting Mitochondrial STAT3 with the Novel Phospho-Valproic Acid (MDC-1112) Inhibits Pancreatic Cancer Growth in Mice.
• Effect on treatment outcome of coinfection with SEN viruses in patients with hepatitis C.
• Decreased expression of DNA-dependent protein kinase, a DNA repair protein, during human colon carcinogenesis.
• Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) alter the kinetics of human colon Cancer cell lines more effectively than traditional NSAIDs: impl...
• The retinoid fenretinide inhibits proliferation and downregulates cyclooxygenase-2 gene expression in human colon adenocarcinoma cell lines.
• Role of diet and NSAIDs in the chemoprevention of Colorectal cancer.
• Is inhibition of cyclooxygenase required for the chemopreventive effect of NSAIDs in colon Cancer? A model reconciling the current contradiction.
• The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis: differential effect on apoptosis in the presence of a co...
• Nonsteroidal anti-inflammatory drugs (NSAIDs), cyclooxygenases, and the cell cycle. Their interactions in colon Cancer.
• Infrared spectroscopic study of cervical smears in patients with HIV: implications for cervical carcinogenesis.
• Altered gastric epithelial cell kinetics in Helicobacter pylori-associated Intestinal metaplasia: implications for gastric carcinogenesis.
• Aspirin for Cancer.
• John Lykoudis: an unappreciated discoverer of the cause and treatment of peptic ulcer Disease.
• The role of cyclooxygenase inhibition in the antineoplastic effects of nonsteroidal antiinflammatory drugs (NSAIDs).
• Cytologically normal cells from neoplastic cervical samples display extensive structural abnormalities on IR spectroscopy: implications for tumor biology.
• A simplified urea breath test for the diagnosis of Helicobacter pylori infection using the LARA System. Laser Assisted Ratio Analyzer.
• Sulindac sulfide alters the expression of cyclin proteins in HT-29 colon adenocarcinoma cells.
• Sulindac sulfide induces several subpopulations of colon Cancer cells, defined by PCNA/Ki-67 and DNA strand breaks.
• Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-inde...
• Effect of aspirin on induction of apoptosis in HT-29 human colon adenocarcinoma cells.
• Nonsteroidal anti-inflammatory drugs and Colorectal cancer: evolving concepts of their chemopreventive actions.
• Fenretinide inhibits phorbol ester-induced cyclooxygenase-2 expression in human colon adenocarcinoma cells.
• Infrared spectroscopy of normal and abnormal cervical smears: evaluation by principal component analysis.
• Colon adenomatous polyps--do they grow inward?
• Sulindac sulfide inhibits the proliferation of colon Cancer cells: diminished expression of the proliferation markers PCNA and Ki-67.
• The effect of eicosanoids on the expression of MHC genes in cultured human colon Cancer cells and mouse colonocytes in vivo.
• Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells.
• PAI-1 gene expression is growth state-regulated in cultured human epidermal keratinocytes during progression to confluence and postwounding.
• Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon Cancer cells by a prostaglandin-independent pathway.
• HLA and disease association: the case of gastric Cancer.
• The effect of leukotrienes B and selected HETEs on the proliferation of colon Cancer cells.
• The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon Cancer cells: alterations in tumor suppressor and cell cycle-regulatory proteins.
• Prostaglandins and the pathophysiology of Esophagitis.
• Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis.
• Expression of HLA class I antigens in sporadic adenomas and histologically normal mucosa of the colon.
• Distinct infrared spectroscopic patterns of human basal cell carcinoma of the skin.
• Breast-feeding and maternal smoking in the etiology of Crohn's Disease and ulcerative colitis in childhood.
• Altered eicosanoid levels in human colon Cancer.
• Molecular gastroenterology--implications for medical practice.
• Lithocholic acid inhibits the expression of HLA class I genes in colon adenocarcinoma cells. Differential effect on HLA-A, -B and -C loci.
• Detection of biotinylated nucleic acids directly on agarose gels.
• The effect of ethanol on the expression of HLA class I genes in human colon adenocarcinoma cell lines.
• Fecal occult blood testing in hospitalized patients.
• The effect of bile acids and piroxicam on MHC antigen expression in rat colonocytes during colon Cancer development.
• Prostaglandin E2 down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell lines.
• Can nonsteroidal anti-inflammatory drugs be recommended to prevent colon Cancer in high risk elderly patients?
• Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells.
• RecA-assisted rapid enrichment of specific clones from model DNA libraries.
• Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo.
• Bipolar electrocautery as an alternative to Nd:YAG laser for the treatment of the watermelon Stomach.
• Concentrations of arachidonic-acid metabolites in human mixed saliva are independent of flow rate.
• Human salivary eicosanoids: circadian variation.
• Identification and quantitation of arachidonic-acid metabolic products in rabbit, rat and human saliva.
• Amiodarone hepatotoxicity. A clinicopathologic study of five patients.
• Eicosanoids and the gastroIntestinal tract: promising but no verdict yet.
• Molecular approaches to the characterization of megabase regions of DNA: applications to the human major histocompatibility complex.
• Rapid plasmid library screening using RecA-coated biotinylated probes.
• Prostaglandins E2 and E2 alpha are elevated in saliva of cystic fibrosis patients.
• The evolving spectrum of amiodarone hepatotoxicity.
• Relative sensitivity and specificity of salivary and serum cotinine in identifying tobacco-smoking status of self-reported nonsmokers and smokers of tobacco and/or mar...
• The circadian rhythm of biliary colic.
• TGF-alpha and TGF-beta expression during sodium-N-butyrate-induced differentiation of human keratinocytes: evidence for subpopulation-specific up-regulation of TGF-bet...
• Human Colorectal cancers display abnormal Fourier-transform infrared spectra.
• Oncogenes and suppressor genes: their involvement in colon Cancer.
• Circadian periodicity of the time of onset of acute lower gastroIntestinal bleeding.
• Reduced expression of HLA class I and II antigens in colon Cancer.
• Infrared spectroscopy of exfoliated human cervical cells: evidence of extensive structural changes during carcinogenesis.
• Circadian periodicity and other clinical features of biliary Pain.
• Human colon adenocarcinoma cell lines display infrared spectroscopic features of malignant colon tissues.
• Loss of colonic HLA antigens in familial adenomatous polyposis.
• NO-NSAIDs and Cancer: promising novel agents.
• Is COX-2 a ''collateral'' target in Cancer prevention?

Schools

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• University Of Athens School Of Health Sciences

• Memorial Hospital Of Rhode Island

• Rhode Island Hospital Lifespan

Procedures Preformed

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• Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
• Endoscopy (Esophagus, Stomach, Small Intestine)

Conditions Treated

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• Abdominal Pain
• Anemia
• Barrett's Esophagus
• Benign Neoplasm of the Digestive System
• View All

Doctors Specialties

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• Gastroenterology

Accepted Insurances

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Education

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• Yale New Haven Children's Center
• Brown University
• Memorial Hospital of Rhode Island
• University of Athens

Hospital

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• Stony Brook University Medical Center

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