Professor, Medicine, University of Washington School of Medicine
Internal Medicine
Dr. Barry J. Cusack, MD
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Doctor Barry J. Cusack, MD works in the field of Internal Medicine. Dr. Barry J. Cusack is also published. He has 56 publications published. The lastest publication: "Age-related pharmacokinetics of daunorubicin and daunorubicinol following intravenous bolus daunorubicin administration in the rat.'
Publications
- Investigations of calsequestrin as a target for anthracyclines: comparison of functional effects of daunorubicin, daunorubicinol, and trifluoperazine.
- Doxorubicin cardiac dysfunction: effects on calcium regulatory proteins, sarcoplasmic reticulum, and triiodothyronine.
- Reduction of 13-deoxydoxorubicin and daunorubicinol anthraquinones by human carbonyl reductase.
- Pharmacokinetics in older persons.
- Anthracycline cardiotoxicity in transgenic mice overexpressing SR Ca2+-ATPase.
- Doxorubicin and C-13 deoxydoxorubicin effects on ryanodine receptor gene expression.
- Decreased sensitivity of neonatal rabbit sarcoplasmic reticulum to anthracycline cardiotoxicity.
- Effect of aging on cardiac contractility in a rat model of chronic daunorubicin cardiotoxicity.
- Physical activity and cognitive function in individuals over 60 years of age: a systematic review.
- Chimeric rat/human neurotensin receptors localize a region of the receptor sensitive to binding of a novel, species-specific, picomolar affinity peptide.
- Effects of caffeine on anterior pituitary and thyroid function in the rat.
- Tangier disease (alpha-lipoprotein deficiency).
- Salicylate intoxication in the elderly. Recognition and recommendations on how to prevent it.
- Pharmacological studies on novel neurotensin mimetics: discovery of a pharmacologically unique agent exhibiting concentration-dependent dual effects as antagonist and ...
- Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer's disease.
- A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist.
- A novel neurotensin peptide analog given extracranially decreases food intake and weight in rodents.
- Drug metabolism in the elderly.
- Overcoming problems with polypharmacy and drug misuse in the elderly.
- Individual and combined effects of cimetidine and ciprofloxacin on theophylline metabolism in male nonsmokers.
- Problems in the use of anticancer drugs in the elderly.
- Therapeutic concentrations of theophylline and enprofylline potentiate catecholamine effects and inhibit leukocyte activation.
- Cigarette smoking and theophylline metabolism: effects of cimetidine.
- Additive effect of theophylline on the cardiac response to isoproterenol.
- Theophylline clearance in patients with severe chronic obstructive pulmonary disease receiving supplemental oxygen and the effect of acute hypoxemia.
- Cigarette smoking and theophylline metabolism: effects of phenytoin.
- Evaluation of a proposed method for phenytoin maintenance dose prediction following an intravenous loading dose.
- Aging and drug interactions. I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men.
- Hepatic drug metabolism and aging.
- Management of drug therapy in the elderly.
- Pharmacokinetic optimisation of drug therapy in elderly patients.
- Phenytoin pharmacokinetics in the rabbit: evidence of rapid autoinduction.
- Aging and drug interactions. II. Effect of phenytoin and smoking on the oxidation of theophylline and cortisol in healthy men.
- Taurine deficiency and doxorubicin: interaction with the cardiac sarcolemmal calcium pump.
- Doxorubicin cardiomyopathy is associated with a decrease in calcium release channel of the sarcoplasmic reticulum in a chronic rabbit model.
- Aging and the response to inhibition and induction of theophylline metabolism.
- Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female ...
- Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol.
- Aging alters the force-frequency relationship and toxicity of oxidative stress in rabbit heart.
- Time-related increases in cardiac concentrations of doxorubicinol could interact with doxorubicin to depress myocardial contractile function.
- Doxorubicin and doxorubicinol pharmacokinetics and tissue concentrations following bolus injection and continuous infusion of doxorubicin in the rabbit.
- Effect of a low-protein diet on doxorubicin pharmacokinetics in the rabbit.
- Effect of phenytoin on the pharmacokinetics of doxorubicin and doxorubicinol in the rabbit.
- Daunorubicin-induced cardiac injury in the rabbit: a role for daunorubicinol?
- Aging increases the cardiotoxicity of daunorubicin and daunorubicinol in the rat.
- Sarcoplasmic reticulum calcium release is stimulated and inhibited by daunorubicin and daunorubicinol.
- Daunorubicin cardiotoxicity: evidence for the importance of the quinone moiety in a free-radical-independent mechanism.
- Prevention by dexrazoxane of down-regulation of ryanodine receptor gene expression in anthracycline cardiomyopathy in the rat.
- Age-related pharmacokinetics of daunorubicin and daunorubicinol following intravenous bolus daunorubicin administration in the rat.
- Daunorubicin and daunorubicinol pharmacokinetics in plasma and tissues in the rat.
- Prevention of chronic anthracycline cardiotoxicity in the adult Fischer 344 rat by dexrazoxane and effects on iron metabolism.
- Blood pressure control and factors predicting control in a treatment-compliant male veteran population.
- Arginine to lysine 108 substitution in recombinant CYP1A2 abolishes methoxyresorufin metabolism in lymphoblastoid cells.
- Randomized, controlled trial of phytoestrogen in the prophylactic treatment of menstrual migraine.
- Effect of dexrazoxane on doxorubicin pharmacokinetics in young and old rats.
Doctors Specialties
- Geriatric Medicine
- Internal Medicine
Accepted Insurances
- Aetna
- Commercial Insurance Company
- Mail Handlers Benefit Plan (MHBP)
- Medicare MCR
- Wells Fargo Insurance
Education
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University College of Dublin National Univ SOM
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