Assistant Professor, Pathology-Brigham and Women's Hospital, Harvard Medical School
Medical Genetics
Dr. Azra H. Ligon, PHD
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Azra H. Ligon, PHD is an expert in the field of Medical Genetics. Azra Ligon has written publications. She has 60 publications published with PubMed. The lastest publication is: 'ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases.'
Publications
- Genetic Basis for PD-L1 Expression in Squamous Cell Carcinomas of the Cervix and Vulva.
- Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype.
- Integrated genomic characterization of a pineal parenchymal tumor of intermediate differentiation.
- Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma.
- Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas.
- Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma.
- High-Resolution Array CGH and Gene Expression Profiling of Alveolar Soft Part Sarcoma.
- Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02.
- Complex cytogenetic rearrangements at the DURS1 locus in syndromic Duane retraction syndrome.
- FOXO3a loss is a frequent early event in high-grade pelvic serous carcinogenesis.
- Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.
- BRAF Duplications and MAPK Pathway Activation Are Frequent in Gliomas of the Optic Nerve Proper.
- DNA Fragmentation Simulation Method (FSM) and Fragment Size Matching Improve aCGH Performance of FFPE Tissues.
- Detection of KIAA1549-BRAF Fusion Transcripts in Formalin-Fixed Paraffin-Embedded Pediatric Low-Grade Gliomas.
- Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
- Reporting of diagnostic cytogenetic results.
- Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.
- Potocki-Lupski syndrome: an inherited dup(17)(p11.2p11.2) with hypoplastic left heart.
- BRAF V600E Mutations Are Common in Pleomorphic Xanthoastrocytoma: Diagnostic and Therapeutic Implications.
- Recurrent BRAF mutations in Langerhans cell histiocytosis.
- Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis.
- Improving the yield of circulating tumour cells facilitates molecular characterisation and recognition of discordant HER2 amplification in breast cancer.
- Establishment and genomic characterization of mouse xenografts of human primary prostate tumors.
- The landscape of somatic copy-number alteration across human cancers.
- Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors.
- Overexpression of elafin in ovarian carcinoma is driven by genomic gains and activation of the nuclear factor kappaB pathway and is associated with poor overall survival.
- Polysomy for chromosomes 1 and 19 predicts earlier recurrence in anaplastic oligodendrogliomas with concurrent 1p/19q loss.
- FOXA1 is a potential oncogene in anaplastic thyroid carcinoma.
- A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors.
- CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity.
- Focal gains of VEGFA and molecular classification of hepatocellular carcinoma.
- Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.
- Disruption of chromodomain helicase DNA binding protein 2 (CHD2) causes scoliosis.
- Characterization of apparently balanced chromosomal rearrangements from the developmental genome anatomy project.
- Molecular studies of segmental aneusomy: FISHing for the atypical cry in del(5)(p15.3).
- NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects.
- Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice.
- Disruption of a synaptotagmin (SYT14) associated with neurodevelopmental abnormalities.
- Candidate loci for Zimmermann-Laband syndrome at 3p14.3.
- Isochromosome of a deleted 20q may be a relatively common abnormality in myeloid malignancies.
- Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas.
- HMGA2 expression in uterine leiomyomata and myometrium: quantitative analysis and tissue culture studies.
- Human chromosome 7: DNA sequence and biology.
- PCOLCE deletion and expression analyses in uterine leiomyomata.
- Spindle cell lipoma and 13q deletion: diagnostic utility of cytogenetic analysis.
- Leiomyomata: heritability and cytogenetic studies.
- Integration of cytogenetic landmarks into the draft sequence of the human genome.
- Genetics of uterine leiomyomata.
- Identification of female carriers for Duchenne and Becker muscular dystrophies using a FISH-based approach.
- Dysregulation of HMGIC in a uterine lipoleiomyoma with a complex rearrangement including chromosomes 7, 12, and 14.
- Expression of HMGIY in three uterine leiomyomata with complex rearrangements of chromosome 6.
- ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases.
- Differentially expressed gene products in glioblastoma cells suppressed for tumorigenicity.
- Gene for multiple exostoses (EXT2) maps to 11(p11.2p12) and is deleted in patients with a contiguous gene syndrome.
- Suppression of transformed phenotype and tumorigenicity after transfer of chromosome 4 into U251 human glioma cells.
- Simultaneous, multilocus FISH analysis for detection of microdeletions in the diagnostic evaluation of developmental delay and mental retardation.
- Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.
- Identification of a novel gene product, RIG, that is down-regulated in human glioblastoma.
- Two tumor suppressive loci on chromosome 10 involved in human glioblastomas.
Doctors Specialties
- Clinical Cytogenetics
- Medical Genetics
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