Professor, Medicine, Boston University School of Medicine

Pulmonology

Avrum Spira practices Pulmonology. He received 1 awards: "Elected Member". Avrum Spira is a published doctor. He published 25 publications, including: 'Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility.'

Publications

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• Update in Lung Cancer 2014.
• SubmiRine: assessing variants in microRNA targets using clinical genomic data sets.
• Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD.
• Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive Pulmonary disease.
• Translating the transcriptome into tools for the early detection and prevention of lung cancer.
• Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data.
• Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk.
• PGE2-Driven Expression of c-Myc and OncomiR-17-92 Contributes to Apoptosis Resistance in NSCLC.
• Association of Interferon- and Transforming Growth Factor β-Regulated Genes and Macrophage Activation With Systemic Sclerosis-Related Progressive Lung Fibrosis.
• Challenge and opportunity of targeted lung cancer chemoprevention.
• Key roles for interferon- and TGF-beta-regulated genes, and macrophage activation in progressive lung fibrosis associated with Systemic Sclerosis.
• MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis.
• Influence of vitamin d status and vitamin d3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial.
• Comparison of Nasal Epithelial Smoking-Induced Gene Expression on Affymetrix Exon 1.0 and Gene 1.0 ST Arrays.
• A Dynamic Bronchial Airway Gene Expression Signature of COPD and Lung Function Impairment.
• Transcription factor klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation.
• Residual expression of reprogramming factors affects the transcriptional program and epigenetic signatures of induced pluripotent stem cells.
• SIRT1 Pathway Dysregulation in the Smoke-Exposed Airway Epithelium and Lung Tumor Tissue.
• Gene-expression patterns in peripheral blood classify familial breast cancer susceptibility.
• Updates and controversies in the rapidly evolving field of lung cancer screening, early detection, and chemoprevention.
• Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era.
• Promoting interdisciplinary research in departments of medicine: results from two models at Boston university school of medicine.
• The Case for a Pre-Cancer Genome Atlas (PCGA).
• Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility.

Schools

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• McGill University Faculty of Medicine

• St Michaels Hospital

• Sunnybrook Health Science Center University Toronto

• Boston Med Center Boston University

Procedures Preformed

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• Bronchoscopy
• Thoracentesis
• Ventilation Management

Conditions Treated

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• Acidosis
• Alkalosis
• Bronchitis
• Pneumonia
• View All

Doctors Specialties

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• Critical Care Medicine
• Pulmonology

Accepted Insurances

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Awards

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• Elected Member

Hospital

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• Boston Medical Center

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