Physician
Anesthesiology
Dr. Anne M. Fagan, MD
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Doctor Anne M. Fagan, MD practices Anesthesiology. She graduated from University of Louisville School of Medicine. University of Louisville School of Medicine is ranked 83 in research and 0 in primary care medicine Anne Fagan is a published doctor as well. She has 100 publications published. The latest was: Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury.
Publications
- Suspected non-Alzheimer disease pathophysiology - concept and controversy.
- Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease.
- Associations Between Biomarkers and Age in the Presenilin 1 E280A Autosomal Dominant Alzheimer Disease Kindred: A Cross-sectional Study.
- Factors associated with the onset and persistence of post-lumbar puncture headache.
- Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory.
- Decreased Platelet APP Isoform Ratios in Autosomal Dominant Alzheimer's Disease: Baseline Data from a DIAN Cohort Subset.
- Task-evoked fMRI changes in attention networks are associated with preclinical Alzheimer's disease biomarkers.
- Unrecognized preclinical Alzheimer disease confounds rs-fcMRI studies of normal aging.
- Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research.
- Functional connectivity in autosomal dominant and late-onset Alzheimer disease.
- Progress Update: Fluid and Imaging Biomarkers in Alzheimer's Disease.
- Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer's Disease.
- A Novel PSEN1 Mutation (I238M) associated with Early-Onset Alzheimer's Disease in an African-American Woman.
- Missense variant in TREML2 protects against Alzheimer's disease.
- Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease.
- Functional connectivity and graph theory in preclinical Alzheimer's disease.
- Preclinical trials in autosomal dominant AD: Implementation of the DIAN-TU trial.
- Relationship between Stroop performance and resting state functional connectivity in cognitively normal older adults.
- Preclinical Alzheimer's disease criteria.
- The PSEN1, p.E318G Variant Increases the Risk of Alzheimer's Disease in APOE-ε4 Carriers.
- Impaired default network functional connectivity in autosomal dominant Alzheimer disease.
- Cerebrospinal Fluid Aβ42, Phosphorylated Tau181, and Resting-State Functional Connectivity.
- Preclinical Alzheimer disease and risk of falls.
- Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later.
- Sleep quality and preclinical Alzheimer disease.
- CSF biomarker variability in the Alzheimer's Association quality control program.
- GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer's Disease.
- SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy.
- Toward a multifactorial model of Alzheimer disease.
- Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition.
- 11C-PiB Imaging of Human Immunodeficiency Virus-Associated Neurocognitive Disorder.
- Cerebrospinal Fluid Proteins Predict Longitudinal Hippocampal Degeneration in Early-stage Dementia of the Alzheimer Type.
- Cerebrospinal fluid biomarkers, education, brain volume, and future cognition.
- Visinin-like protein-1: Diagnostic and prognostic biomarker in Alzheimer disease.
- The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.
- Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
- Comparison of Analytical Platforms for Cerebrospinal Fluid Measures of {beta}-Amyloid 1-42, Total tau, and P-tau181 for Identifying Alzheimer Disease Amyloid Plaque Pa...
- Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic gu...
- Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease.
- Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis.
- YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease.
- Exercise and Alzheimer's disease biomarkers in cognitively normal older adults.
- Cortical binding of pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease.
- APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging.
- Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case...
- Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease.
- The utility of intraindividual variability in selective attention tasks as an early marker for Alzheimer's disease.
- Biomarkers of Alzheimer's disease.
- Cerebrospinal fluid biomarkers and rate of cognitive decline in very mild dementia of the Alzheimer type.
- Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.
- Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly.
- Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition.
- Cerebral amyloid-beta protein accumulation with aging in cotton-top tamarins: a model of early Alzheimer's disease?
- Extreme cerebrospinal fluid amyloid beta levels identify family with late-onset Alzheimer's disease presenilin 1 mutation.
- Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults.
- Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease.
- Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia.
- Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.
- Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid.
- P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model.
- Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta.
- ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral ...
- Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia.
- Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content.
- Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.
- Quantitative Label-Free Proteomics for Discovery of Biomarkers in Cerebrospinal Fluid: Assessment of Technical and Inter-Individual Variation.
- Normal olfactory discrimination learning set and facilitation of reversal learning after medial-temporal damage in rats: implications for an account of preserved learn...
- Normal learning set and facilitation of reversal learning in rats with combined fornix-amygdala lesions: implications for preserved learning abilities in amnesia.
- Nerve growth factor function in the central nervous system.
- Effects of brain-derived neurotrophic factor and nerve growth factor on remaining neurons in the lesioned nucleus basalis magnocellularis.
- Mechanisms of sprouting in the adult central nervous system: cellular responses in areas of terminal degeneration and reinnervation in the rat hippocampus.
- Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder.
- Endogenous FGF-2 is important for cholinergic sprouting in the denervated hippocampus.
- Potential role of apoE in structural plasticity in the nervous system; implications for disorders of the central nervous system.
- Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice.
- Alzheimer Research Forum live discussion: insulin resistance: a common axis linking Alzheimer''s, depression, and metabolism?
- Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB: a case-control study.
- Lipoproteins in the central nervous system.
- Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and...
- Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury.
- No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo.
- A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo.
- Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice.
- Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-beta deposition in vivo.
- Improving CSF biomarker accuracy in predicting prevalent and incident Alzheimer disease.
- Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.
- Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice.
- Alternative processing of ?-secretase substrates in common forms of mild cognitive impairment and alzheimer's disease: Evidence for ?-secretase dysfunction.
- Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype.
- Role of family history for Alzheimer biomarker abnormalities in the adult children study.
- APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF A?42.
- CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease.
- High density lipoprotein decreases beta-amyloid toxicity in cortical cell culture.
- Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.
- Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.
- Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease.
- Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein.
- Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein.
- The search for antecedent biomarkers of Alzheimer''s disease.
Schools
University of Louisville School of Medicine
Louisville Genl Hospital
Milwaukee Co Genl Hospital
Doctors Specialties
- Anesthesiology
Accepted Insurances
Education
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Medical College of Wisconsin Affiliated Hospitals -
University of Louisville School of Medicine
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