Professor, Pediatrics, University of Wisconsin School of Medicine and Public Health
Pediatric Rheumatology
Dr. Anna Huttenlocher, MD
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Dr. Anna Huttenlocher practices Pediatric Rheumatology. She went to medical school at Harvard Medical School. Harvard Medical School is a one of the best medicals schools. Harvard Medical School has a rank of 1 in research and a 12 in primary care She has 3 awards "Elected Member", "Fellow (FACR)" and "Fellow". Anna Huttenlocher is a published doctor and has 99 publications published. The lastest was: 'Microfluidic device for simultaneous analysis of neutrophil extracellular traps and production of reactive oxygen species.'
Publications
- Microfluidic device for simultaneous analysis of neutrophil extracellular traps and production of reactive oxygen species.
- Neutrophils in host defense: new insights from zebrafish.
- Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration.
- Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.
- Inflammation and wound repair.
- Distinct Innate Immune Phagocyte Responses to Aspergillus fumigatus Conidia and Hyphae in Zebrafish Larvae.
- Choosing Wisely: The American College of Rheumatology's Top 5 for Pediatric Rheumatology.
- Characterizing asthma from a drop of blood using neutrophil chemotaxis.
- Peptidylarginine deiminase 4 contributes to tumor necrosis factor alpha induced inflammatory Arthritis.
- The F-bar protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages.
- Neutrophil migration: moving from zebrafish models to human autoimmunity.
- Interstitial leukocyte migration in vivo.
- WRAMPing Up Calcium in Migrating Cells by Localized ER Transport.
- The focal adhesion kinase inhibitor PF-562,271 impairs primary CD4+ T cell activation.
- Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish.
- Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites.
- Rational design of a ligand-controlled protein conformational switch.
- Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging.
- ECM: chemoattraction but not adhesion.
- Kit-On-A-Lid-Assays for accessible self-contained cell assays.
- Innate Immune Response to Streptococcus iniae Infection in Zebrafish Larvae.
- Neutrophil Reverse Migration Becomes Transparent with Zebrafish.
- Spatiotemporal regulation of Src and its substrates at invadosomes.
- The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis.
- In vivo imaging and characterization of actin microridges.
- Live Imaging and Gene Expression Analysis in Zebrafish Identifies a Link between Neutrophils and Epithelial to Mesenchymal Transition.
- Spinning disk confocal imaging of neutrophil migration in zebrafish.
- Heat shock modulates neutrophil motility in zebrafish.
- Lyn is a redox sensor that mediates leukocyte wound attraction in vivo.
- Contact-dependent T cell activation and T cell stopping require talin1.
- Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue.
- Live imaging of LFA-1-dependent T-cell motility and stop signals.
- A live imaging cell motility screen identifies prostaglandin E2 as a T cell stop signal antagonist.
- Integrins in cell migration.
- Imaging podosome dynamics and matrix degradation.
- Hax1 regulates neutrophil adhesion and motility through RhoA.
- CalPain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration.
- Rapid prototyping of arrayed microfluidic systems in polystyrene for cell-based assays.
- Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish.
- Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia.
- Introduction to the mechanisms of directed cell migration themed issue.
- An arrayed high-content chemotaxis assay for patient diagnosis.
- PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells.
- Live imaging of neutrophil motility in a zebrafish model of WHIM Syndrome.
- Impaired podosome formation and invasive migration of macrophages from patients with a PSTPIP1 mutation and PAPA Syndrome.
- CalPain 4 is not necessary for LFA-1-mediated function in CD4+ T cells.
- Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish.
- Regulation of adhesion dynamics by calPain-mediated proteolysis of focal adhesion kinase (FAK).
- Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation.
- Erythrocyte scaffolding protein p55/MPP1 functions as an essential regulator of neutrophil polarity.
- CalPain inhibition impairs TNF-alpha-mediated neutrophil adhesion, arrest and oxidative burst.
- Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T cell/antigen-presenting cell interactions.
- Neutrophil motility in vivo using zebrafish.
- Innate immunity: wounds burst H2O2 signals to leukocytes.
- Characterization of zebrafish larval inflammatory macrophages.
- The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish.
- Selective and tunable gradient device for cell culture and chemotaxis study.
- FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion.
- Modulation of neutrophil function by a secreted mucinase of Escherichia coli O157:H7.
- Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin.
- Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos.
- Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24.
- The calPain small subunit regulates cell-substrate mechanical interactions during fibroblast migration.
- Neutrophil dysfunction in a family with a SAPHO Syndrome-like phenotype.
- A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment.
- Natural killer T-cell autoreactivity leads to a specialized activation state.
- The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration.
- Reverse leukocyte migration can be attractive or repulsive.
- Analysis of neutrophil polarization and chemotaxis.
- Adhesions ring: a structural comparison between podosomes and the immune synapse.
- CalPain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.
- Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish.
- Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis.
- Live imaging of chronic inflammation caused by mutation of zebrafish Hai1.
- RACK1 regulates Src activity and modulates paxillin dynamics during cell migration.
- Analysis of neutrophil chemotaxis.
- Wound healing with electric potential.
- Asymmetric localization of calPain 2 during neutrophil chemotaxis.
- Talin1 regulates TCR-mediated LFA-1 function.
- Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish.
- The conserved C-terminal I/LWEQ module targets Talin1 to focal adhesions.
- Characterization of a membrane-based gradient generator for use in cell-signaling studies.
- TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calPain.
- Proteolysis of cortactin by calPain regulates membrane protrusion during cell migration.
- Neutrophil chemotaxis in a patient with neonatal-onset multisystem inflammatory disease and Muckle-Wells Syndrome.
- Regulating cell migration: calPains make the cut.
- CalPain proteases in cell adhesion and motility.
- TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway.
- Cell polarization mechanisms during directed cell migration.
- Thalidomide for severe systemic onset juvenile Rheumatoid arthritis: A multicenter study.
- CalPain-mediated proteolysis of talin regulates adhesion dynamics.
- Extracellular matrix molecules regulate endothelial cell migration stimulated by lysophosphatidic acid.
- Isoform specific function of calPain 2 in regulating membrane protrusion.
- Filopodial calcium transients regulate growth cone motility and guidance through local activation of calPain.
- Cytokine abnormalities in a patient with eosinophilic fasciitis.
- Ligand density modulates eosinophil signaling and migration.
- CalPain regulates neutrophil chemotaxis.
- Dynamic imaging of cell-substrate contacts.
Schools
Harvard Medical School
Boston Chldns Hospital
Conditions Treated
- Patellofemoral Pain Syndrome or Knee Pain
- Rheumatoid Arthritis
- Still's Disease
Doctors Specialties
- Pediatric Rheumatology
Accepted Insurances
Awards
- Elected Member
- Fellow (FACR)
- Fellow
Education
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UCSF Medical Center -
Boston Children's Hospital -
Harvard Medical School
Hospital
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University of Wisconsin Hospital and Clinics
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