Physician

Anesthesiology

Anisar Akbar works in the field of Anesthesiology. He went to medical school at Medical College of Wisconsin Affiliated Hospitals. Dr. Anisar Akbar is a published MD. He published 101 publications, including: 'IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire.'

Publications

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• IL-15--friend or foe in transplantation rejection?
• Memory T cells constitute a subset of the human CD8+CD45RA+ pool with distinct phenotypic and migratory characteristics.
• Human tenon's fibroblast-produced ifnbeta and the prevention of t-cell apoptosis.
• The flow cytometric analysis of telomere length in antigen-specific CD8+ T cells during acute Epstein-Barr virus infection.
• Regulation of apoptosis and replicative senescence in CD8+ T cell following acute viral infection.
• Type 1 IFN maintains the survival of anergic CD4+ T cells.
• The role of the immune system in conjunctival wound healing after glaucoma surgery.
• Virus-induced CD8+ T cell clonal expansion is associated with telomerase up-regulation and telomere length preservation: a mechanism for rescue from replicative senesc...
• IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire.
• The role of apoptosis in the resolution of T cell-mediated cutaneous inflammation.
• Role for Bcl-xL in delayed eosinophil apoptosis mediated by granulocyte-macrophage colony-stimulating factor and interleukin-5.
• Antimetabolite-induced apoptosis in Tenon's capsule fibroblasts.
• Upregulation of intracellular glutathione by fibroblast-derived factor(s): enhanced survival of activated T cells in the presence of low Bcl-2.
• Dissociation of T cell anergy from apoptosis by blockade of Fas/Apo-1 (CD95) signaling.
• In situ immune responses in Crohn's disease: a comparison with acute and persistent measles virus infection.
• Inhibition of T cell apoptosis in the rheumatoid synovium.
• Induction of apoptosis following antigen presentation by T cells: anergy and apoptosis are two separate phenomena.
• Regulation of bcl-2 and fas expression in primary activation of human peripheral lymphocytes is not sensitive to dexamethasone or cyclosporin-A.
• Neurocirculatory responses to intubation with either an endotracheal tube or laryngeal mask airway in humans.
• Presence of CD3+CD8+Bcl-2(low) lymphocytes undergoing apoptosis and activated macrophages in lymph nodes of HIV-1+ patients.
• Patient preference in choosing biological therapy in Crohn's disease.
• A five-year clinical study of formocresol treatment in 120 cases of pulpotomy in permanent molars.
• Immunological abnormalities in thalassaemia major. I. A transfusion-related increase in circulating cytoplasmic immunoglobulin-positive cells.
• Review article: visceral hypersensitivity in irritable bowel syndrome: molecular mechanisms and therapeutic agents.
• Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain.
• Anisakiasis--a neglected diagnosis in the West.
• Interpretation of Mycobacterium tuberculosis antigen-specific IFN-gamma release assays (T-SPOT.TB) and factors that may modulate test results.
• Transfusion-related immunologic abnormalities in beta-thalassemia major.
• Spontaneous and Concanavalin A-induced suppressor activity in control and Hodgkin''s disease patients.
• HTLV-III neutralizing antibody development in transfusion-dependent seropositive patients with beta-thalassemia.
• Disproportionate lymphoid cell subsets in thalassaemia major: the relative contributions of transfusion and splenectomy.
• Immunosenescence and Cytomegalovirus: where do we stand after a decade?
• Aminoglycoside-associated hypomagnesaemia in children with cystic fibrosis.
• Vulval Crohn's disease: a tertiary center experience of 23 patients.
• Decreased natural killer activity in thalassemia major: a possible consequence of iron overload.
• Modulation of the defective natural killer activity seen in thalassaemia major with desferrioxamine and alpha-interferon.
• Type I interferons inhibit the resolution of chronic inflammation.
• Kinetics of T lymphocyte development.
• Patients with B cell chronic lymphocytic leukaemia have an expanded population of CD4 perforin expressing T cells enriched for human cytomegalovirus specificity and an...
• Immunological reason for chronic ill health after infectious mononucleosis.
• The use of the inhibitory receptors for modulating the immune responses.
• Life (and death) in the Fas lane.
• Polyfunctional T cells accumulate in large human cytomegalovirus-specific T cell responses.
• Human immunosenescence: is it infectious?
• Suppression of the mixed lymphocyte reaction by alloantigen-primed and -stimulated human spleen lymphocytes.
• Telomere-dependent senescence.
• Anti-CD28 enhances defective mitogen responses by mononuclear cells from patients with common variable immunodeficiency.
• Cytotoxic CD4+ T cells in patients with B cell chronic lymphocytic leukemia kill via a perforin-mediated pathway.
• A study of the immunology of the chronic fatigue syndrome: correlation of immunologic parameters to health dysfunction.
• Follicular dendritic cells share a membrane-bound protein with fibroblasts.
• Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation.
• [Role of Bcl-xL in cytokine-induced delay of eosinophilia apoptosis].
• In vivo production of interferon beta by human Tenon''s fibroblasts; a possible mediator for the development of chronic conjunctival inflammation.
• Phenotypic analysis of IL-10-treated macrophages using the monoclonal antibodies RFD1 and RFD7.
• Is immunosenescence infectious?
• T-lymphocyte-fibroblast interactions.
• Relative impact of CD4+CD25+ regulatory T cells and tacrolimus on inhibition of T-cell proliferation in patients with atopic dermatitis.
• Increased adherence of CD2 peripheral blood lymphocytes to cytomegalovirus-infected fibroblasts is blocked by anti-LFA-3 antibody.
• Characterization of a human T cell-specific chimeric antibody (CD7) with human constant and mouse variable regions.
• Co-stimulation with anti-CD28 (Kolt-2) enhances DNA synthesis by defective T cells in common variable immunodeficiency.
• Herbimycin A accelerates the induction of apoptosis following etoposide treatment or gamma-irradiation of bcr/abl-positive leukaemia cells.
• Extrathymic T cell differentiation in the human intestine early in life.
• The immunomodulatory effects of regulatory T cells: implications for immune regulation in the skin.
• Active systemic lupus erythematosus is associated with the recruitment of naive/resting T cells.
• Subpopulations of primed T helper cells in rheumatoid arthritis.
• The regulation of apoptosis in resting T lymphocytes.
• Cellular environments and apoptosis: tissue microenvironments control activated T-cell death.
• Quantitative flow cytometry for the analysis of T cell receptor Vbeta chain expression.
• CD4+ CD45RA+ T cells from adults respond to recall antigens after CD28 ligation.
• The development of primed/memory CD8+ lymphocytes in vitro and in rejecting kidneys after transplantation.
• Selective migration of highly differentiated primed T cells across human umbilical vein endothelial cells.
• The synergy between naive and memory T cells during activation.
• A possible role for bcl-2 in regulating T-cell memory--a ''balancing act'' between cell death and survival.
• The inhibition of cutaneous T cell apoptosis may prevent resolution of inflammation in atopic eczema.
• Peripheral generation and function of CD4+CD25+ regulatory T cells.
• RGD peptides induce apoptosis by direct caspase-3 activation.
• IFN-alpha and IFN-beta: a link between immune memory and chronic inflammation.
• Immune regulation by CD4+CD25+ regulatory T cells: implications for transplantation tolerance.
• T lymphocyte mediated lysis of mitomycin C treated Tenon''s capsule fibroblasts.
• Loss of CD28 expression on CD8(+) T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN, and increases susceptibility to activation-induc...
• Regulation of apoptosis and replicative senescence in CD8+ T cells from patients with viral infections.
• High cell density provides potent survival signals for resting T-cells.
• Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28- T cells.
• Role of bcl-2 and apoptosis in viral infections.
• Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.
• Cellular events during memory T-cell activation in vitro: the UCHL1 (180,000 MW) determinant is newly synthesized after mitosis.
• Significance of senescence for virus-specific memory T cell responses: rapid ageing during chronic stimulation of the immune system.
• Inhibition of alloresponsive naive and memory T cells by CD7 and CD25 antibodies and by cyclosporine.
• Human cytomegalovirus infection up-regulates interleukin-8 gene expression and stimulates neutrophil transendothelial migration.
• The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis.
• The effect of a chimeric mouse-human CD7 antibody on human T, natural killer, and lymphokine-activated killer cell activity in vitro.
• Human CD4+CD45R0+ and CD4+CD45RA+ T cells synergize in response to alloantigens.
• The specific recognition by macrophages of CD8+,CD45RO+ T cells undergoing apoptosis: a mechanism for T cell clearance during resolution of viral infections.
• Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-...
• The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory.
• Immature CD45RA(low)RO(low) T cells in the human cord blood. I. Antecedents of CD45RA+ unprimed T cells.
• Factors that influence activated CD8+ T-cell apoptosis in patients with acute herpesvirus infections: loss of costimulatory molecules CD28, CD5 and CD6 but relative ma...
• Fibroblasts prevent apoptosis of IL-2-deprived T cells without inducing proliferation: a selective effect on Bcl-XL expression.
• Selective migration of highly differentiated primed T cells, defined by low expression of CD45RB, across human umbilical vein endothelial cells: effects of viral infec...
• Interferon-beta mediates stromal cell rescue of T cells from apoptosis.

Schools

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• King Edward Medical University

• Sinai Samaritan Med Center University Wisc

• Med College Wisc

Doctors Specialties

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• Anesthesiology

Accepted Insurances

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Education

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• Medical College of Wisconsin Affiliated Hospitals
• King Edward Medical University

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