Poth Professor of Cutaneous Oncology; Professor, Departments of Dermatology and Cell and Developmental Biology, University of Michigan Medical School
Dermatology
Dr. Andrzej A. Dlugosz, MD
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Andrzej Dlugosz practices Dermatology. He studied medicine at Penn State College of Medicine. He has 14 awards "Member", "The William Montagna Lectureship", "7th Annual Jeffrey Schechner Memorial Lecturer", "CMS Meaningful Use Stage 1 Certification", "27th Annual Pillsbury Lecturer", "Marion B. Sulzberger, MD, Memorial Award and Lectureship", "Acne Research Award", "Best Doctors in America", "Elected Member", "Howard Fox Lecturer", "29th Annual Louis A. Duhring Memorial Lecturer", "Proctor and Gamble Lectureship", "Research Award" and "Fellow (FAAD)". Dr. Andrzej A. Dlugosz is a published MD. He published 99 publications, including: 'Essential role for Sonic hedgehog during hair follicle morphogenesis.' He accepts all Medicare patients.
Publications
- Next generation sequencing of Cytokeratin 20-negative Merkel Cell carcinoma reveals ultraviolet-signature mutations and recurrent TP53 and RB1 inactivation.
- The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma.
- Hedgehog pathway blockade with the cancer drug LDE225 disrupts taste organs and taste sensation.
- Merkel Cell Polyomavirus Small T Antigen is Oncogenic in Transgenic Mice.
- The sonic hedgehog-induced type 3 deiodinase facilitates tumorigenesis of Basal cell carcinoma by reducing Gli2 inactivation.
- Merkel Cell Carcinoma Dependence on Bcl-2 Family Members for Survival.
- Keratin 79 identifies a novel population of migratory epithelial Cells that initiates hair canal morphogenesis and regeneration.
- Multiple Shh signaling centers participate in fungiform papilla and taste bud formation and maintenance.
- Harnessing hedgehog for the treatment of Basal cell carcinoma.
- Distinct Gene Expression Profiles of Viral- and Nonviral-Associated Merkel Cell Carcinoma Revealed by Transcriptome Analysis.
- Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia.
- Transgenic Expression of Interferon-γ in Mouse Stomach Leads to Inflammation, Metaplasia, and Dysplasia.
- Vismodegib.
- Montagna symposium 2011: 60th anniversary-advances in science and medicine catalyzed by pioneering Skin research.
- Huntingtin-Interacting Protein 1: A Merkel Cell Carcinoma Marker that Interacts with c-Kit.
- Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations.
- Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in Skin.
- TRP channel regulates EGFR signaling in hair morphogenesis and Skin barrier formation.
- Following the hedgehog to new cancer therapies.
- Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.
- Dual and opposing roles of primary cilia in medulloblastoma development.
- Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning.
- A susceptibility locus on 1p32-1p34 for conGenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation.
- Lack of evidence for activation of the hedgehog pathway in psoriasis.
- Pathological responses to oncogenic Hedgehog signaling in Skin are dependent on canonical Wnt/beta3-catenin signaling.
- Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis.
- Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes.
- Intrinsic differences among spatially distinct neural crest stem Cells in terms of migratory properties, fate determination, and ability to colonize the enteric nervou...
- Wnt-beta-catenin signaling initiates taste papilla development.
- Hedgehog/Ras interactions regulate early stages of pancreatic cancer.
- Odontogenic keratocysts arise from quiescent epithelial rests and are associated with deregulated hedgehog signaling in mice and humans.
- Sustained Hedgehog signaling is required for Basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle.
- Hedgehog signaling regulates sebaceous gland development.
- Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the Hair cycle in mice.
- Sonic hedgehog-dependent activation of Gli2 is essential for embryonic Hair follicle development.
- Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters Skin tumor phenotype.
- Bone morphogenetic protein antagonist noggin promotes Skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways.
- Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion.
- Activation of beta-catenin signaling programs embryonic epidermis to Hair follicle fate.
- Reduced pepsin A processing of sonic hedgehog in parietal Cells precedes gastric atrophy and transformation.
- Common activation of canonical Wnt signaling in pancreatic adenoCarcinoma.
- A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2.
- Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.
- Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in Skin leading to neonatal death.
- Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1.
- Gli proteins up-regulate the expression of basonuclin in Basal cell carcinoma.
- Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in Hair follicle morphogenesis.
- The magnitude of hedgehog signaling activity defines Skin tumor phenotype.
- Progress in cutaneous cancer research.
- Basal cell carcinomas in mice overexpressing Gli2 in skin.
- Essential role for Sonic hedgehog during Hair follicle morphogenesis.
- Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the Hair follicle and normal Hair development.
- Differentiation of cultured human epidermal keratinocytes at high Cell densities is mediated by endogenous activation of the protein kinase C signaling pathway.
- Cross-talk between epidermal growth factor receptor and protein kinase C during calcium-induced differentiation of keratinocytes.
- Multistage carcinogenesis in the Skin.
- Protein kinase C regulates keratinocyte transglutaminase (TGK) gene expression in cultured primary mouse epidermal keratinocytes induced to terminally differentiate by...
- Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-ras(Ha) oncogene but does not block in vitro keratin...
- Staurosporine induces protein kinase C agonist effects and maturation of normal and neoplastic mouse keratinocytes in vitro.
- Analysis of phospholipid metabolism in murine keratinocytes transformed by the v-ras oncogene: relationship of phosphatidylinositol turnover and cytokine stimulation t...
- Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alpha.
- Definition by specific antisense oligonucleotides of a role for protein kinase C alpha in expression of differentiation markers in normal and neoplastic mouse epiderma...
- Staurosporine induces a complete program of terminal differentiation in neoplastic mouse keratinocytes via activation of protein kinase C.
- The role of growth factors in mouse Skin tumor promotion and premalignant progression.
- Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subCellular distribution of Gli1.
- Keratinocyte growth factor receptor ligands induce transforming growth factor alpha expression and activate the epidermal growth factor receptor signaling pathway in c...
- Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ...
- Epidermal growth factor receptor ligands regulate keratin 8 expression in keratinocytes, and transforming growth factor alpha mediates the induction of keratin 8 by th...
- Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta.
- Staurosporine induces a sequential program of mouse keratinocyte terminal differentiation through activation of PKC isozymes.
- The Hedgehog and the Hair follicle: a growing relationship.
- Differentiation of mouse keratinocytes is accompanied by PKC-dependent changes in AP-1 proteins.
- Basal cell carcinoma, hedgehog signaling, and targeted therapeutics: the long and winding road.
- Alterations in the biology and biochemistry of keratinocytes induced by the ras oncogene.
- Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation.
- Activation of human squamous Cell carcinoma ornithine decarboxylase activity by guanosine triphosphate.
- Production of infectious bovine papillomavirus from cloned viral DNA by using an organotypic raft/xenograft technique.
- Isolation and utilization of epidermal keratinocytes for oncogene research.
- The in vitro analysis of biochemical changes relevant to Skin carcinogenesis.
- Coordinate changes in gene expression which mark the spinous to granular Cell transition in epidermis are regulated by protein kinase C.
- Transcripts encoding protein kinase C-alpha, -delta, -epsilon, -zeta, and -eta are expressed in Basal and differentiating mouse keratinocytes in vitro and exhibit quan...
- Role of oncogenes and tumor suppressor genes in multistage carcinogenesis.
- Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium.
- Inhibition of tumor formation from grafted murine papilloma Cells by treatment of grafts with staurosporine, an inducer of squamous differentiation.
- Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C delta.
- Differential regulation by anti-tumor-promoting 12-deoxyphorbol-13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biologi...
- Regulation of ornithine decarboxylase in normal and neoplastic mouse and human epidermis.
- Macrophage-stimulating protein induces proliferation and migration of murine keratinocytes.
- Signal transduction in normal and neoplastic keratinocytes.
- Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype.
- TPA reversibly blocks the differentiation of chick myogenic, chondrogenic, and melanogenic Cells.
- Hepatocanalicular injury associated with vitamin A derivative etretinate. An idiosyncratic hypersensitivity reaction.
- Effects of 12-O-tetradecanoyl-phorbol-13-acetate on Myofibril integrity and Ca2+ content in developing myotubes.
- Verrucous annular ulcerated hip plaques. Diagnosis: superficial Granulomatous pyoderma form of pyoderma gangrenosum.
- Effects of phorbol 12-myristate 13-acetate on the differentiation program of embryonic chick skeletal myoblasts.
- Development of ''revertant'' myotubes in cultures of Rous sarcoma virus transformed avian myogenic Cells.
- Immunocytochemical evaluation of gastric mucosal cathepsin D in peptic ulcer.
- Synthesis and biological activity of pyrimidobenzodiazepine derivatives. New ring systems: triazolo- and tetrazolo-pyrimido-benzodiazepines.
- Selective effects of phorbol 12-myristate 13-acetate on myofibrils and 10-nm filaments.
Schools
Pennsylvania State University College Of Medicine
Roger Williams Genl Hospital
University Of Pennsylvania
National Cancer Institute
Procedures Preformed
- Acne Surgery
- Destruction of Benign Skin Lesion
- Destruction of Malignant Skin Lesion
- Skin Tag Removal
Conditions Treated
- Acanthosis Nigricans
- Acne
- Actinic Keratosis
- Athlete's Foot
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Doctors Specialties
- Dermatology
Accepted Insurances
Awards
- Member
- The William Montagna Lectureship
- 7th Annual Jeffrey Schechner Memorial Lecturer
- CMS Meaningful Use Stage 1 Certification
- 27th Annual Pillsbury Lecturer
- Marion B. Sulzberger, MD, Memorial Award and Lectureship
- Acne Research Award
- Best Doctors in America
- Elected Member
- Howard Fox Lecturer
- 29th Annual Louis A. Duhring Memorial Lecturer
- Proctor and Gamble Lectureship
- Research Award
- Fellow (FAAD)
Education
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University of Pennsylvania Health System -
Penn State College of Medicine
Hospital
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University of Michigan Hospitals and Health Centers
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1295822047 |
| Last Name Of The Provider | DLUGOSZ |
| First Name Of The Provider | ANDRZEJ |
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