Director of Commonwealth Spine; Director of Brandywine Valley Neurosurgery and Spine; Director of Neurosurgery at Brandywine Hospital; CEO of FreeseTEC
Neurosurgery
Dr. Andrew Freese, MD
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Andrew Freese works in the field of Neurosurgery. He went to medical school at Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. He has 17 awards "Patients Choice Award", "Vitals Compassionate Doctor Recognition", "Top Doc Neurosurgeon in the Philadelphia region", "Physician/Scientist of the Year Award", "Strawbridge Research Fund Award", "Who's Who in Science and Engineering", "Who's Who in America", "Who's Who in Healthcare and Medicine", "DeHillebranth Foundation Research Award", "American Men and Women of Science", "Nemir Research Foundation Award", "High Honors Thesis (Biochemistry)", "Harvard University Scholarships", "Dean's List", "Fellow (FAANS)", "Sigma Xi" and "Recognized Physician". Andrew Freese is also published. He has 39 publications published. The lastest publication: "In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector.'
Publications
- Long-term follow-up after gene therapy for canavan Disease.
- Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression.
- Efficacy of nonviral gene transfer in the canine Brain.
- Optimization of adenoviral vector-mediated transgene expression in the canine Brain in vivo, and in canine glioma cells in vitro.
- Adenoviral-mediated gene transfer into the canine Brain in vivo.
- Natural history of Canavan Disease revealed by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted MRI.
- Immune responses to AAV in a phase I study for Canavan Disease.
- Nonviral vectors for Cancer gene therapy: prospects for integrating vectors and combination therapies.
- Mild-onset presentation of Canavan's Disease associated with novel G212A point mutation in aspartoacylase gene.
- Combinatorial antiangiogenic gene therapy by nonviral gene transfer using the sleeping beauty transposon causes tumor regression and improves survival in mice bearing...
- Emerging concepts in glioma biology: implications for clinical protocols and rational treatment strategies.
- Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan Disease.
- Effect of altering titer, serotype, and promoter in recombinant adenoassociate virus gene therapy expression of Spinal cord neurons and astrocytes.
- Clinical protocol. Gene therapy of Canavan disease: AAV-2 vector for neurosurgical delivery of aspartoacylase gene (ASPA) to the human Brain.
- Viral-based gene transfer to the mammalian CNS for functional genomic studies.
- Aspartoacylase gene transfer to the mammalian central Nervous system with therapeutic implications for Canavan disease.
- Multi-site partitioned delivery of human tyrosine hydroxylase gene with phenotypic recovery in Parkinsonian rats.
- Restorative gene therapy approaches to Parkinson's Disease.
- In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector.
- Direct gene transfer into human epileptogenic hippocampal tissue with an adeno-associated virus vector: implications for a gene therapy approach to Epilepsy.
- Adenovirus vector-mediated gene transfer into human epileptogenic Brain slices: prospects for gene therapy in epilepsy.
- Analysis of harvest morbidity and radiographic outcome using autograft for anterior Cervical fusion.
- Parkinson's Disease: the case for novel treatment strategies.
- MR of thoracic cord compression caused by epidural extramedullary hematopoiesis in myelodysplastic Syndrome.
- Outcome analysis for adults with Spondylolisthesis treated with posterolateral fusion and transpedicular screw fixation.
- Prospects for gene therapy in Parkinson's Disease.
- Transfection of human lactotroph adenoma cells with an adenovirus vector expressing tyrosine hydroxylase decreases prolactin release.
- Hippocampal cell distributions in temporal lobe Epilepsy: a comparison between patients with and without an early risk factor.
- An HSV-1 vector expressing tyrosine hydroxylase causes production and release of L-dopa from cultured rat striatal cells.
- Biochemical and behavioral recovery in a rodent model of Parkinson's Disease following stereotactic implantation of dopamine-containing liposomes.
- Infection of cultured striatal neurons with a defective HSV-1 vector: implications for gene therapy.
- Extended levodopa release from a subcutaneously implanted polymer matrix in rats.
- Levodopa delivery from controlled-release polymer matrix: delivery of more than 600 days in vitro and 225 days of elevated plasma levels after subcutaneous implantatio...
- HSV-1 vector mediated neuronal gene delivery. Strategies for molecular neuroscience and neurology.
- Controlled-release dopamine polymers as a novel approach to the treatment of Parkinson's Disease.
- Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors.
- Infection of cultured central Nervous system neurons with a defective herpes simplex virus 1 vector results in stable expression of Escherichia coli beta-galactosidase.
- Controlled release of dopamine from a polymeric Brain implant: in vivo characterization.
Schools
Harvard Medical School
University Of Pennsylvanis
University Of Pennsylvania
Massachusettes Institute Of Technology
Procedures Preformed
- Craniectomy, Craniotomy, Surgery of Skull Base, Neuroendoscopy
- Dural Repair or Other Spinal Spinal Cord Repair
- Epidural Lysis of Adhesions (LOA)
- Herniated Disc Surgery
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Conditions Treated
- Ankylosing Vertebral Hyperostosis
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
- Brain Aneurysm
- Brain Cancer
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Doctors Specialties
- Neurosurgery
Accepted Insurances
Awards
- Patient’s Choice Award
- Vitals Compassionate Doctor Recognition
- ‘Top Doc’ Neurosurgeon in the Philadelphia region
- Physician/Scientist of the Year Award
- Strawbridge Research Fund Award
- Who's Who in Science and Engineering
- Who's Who in America
- Who's Who in Healthcare and Medicine
- DeHillebranth Foundation Research Award
- American Men and Women of Science
- Nemir Research Foundation Award
- High Honors Thesis (Biochemistry)
- Harvard University Scholarships
- Dean's List
- Fellow (FAANS)
- Sigma Xi
- Recognized Physician
Education
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University of Pennsylvania Health System -
Harvard Medical School -
Harvard University
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