Professor of Medicine, Vanderbilt University
Endocrinology
Dr. Alvin C. Powers Jr., MD
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Dr. Alvin C. Powers Jr. works in the field of Endocrinology. He went to University of Tennessee College of Medicine. He received 4 awards: "America's Top Doctors", "Nashville Lifestyles Magazine", "Women's Health" and "Men's Health". Alvin C. Powers Jr. is a published physician as well. He has 101 publications published. The latest was: Different functional domains of GLUT2 glucose transporter are required for glucose affinity and substrate specificity. Alvin Powers is registered with Medicare.
Publications
- Pathogenic CD4 T cells in type 1 Diabetes recognize epitopes formed by peptide fusion.
- Inactivating the permanent neonatal Diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-c...
- Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish.
- The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice.
- The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth.
- Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but not Insulin Action in High Fat-Fed Mice.
- Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding.
- Islet Microenvironment, Modulated by Vascular Endothelial Growth Factor-A Signaling, Promotes β Cell Regeneration.
- Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets.
- Pancreatic islet vasculature adapts to insulin resistance through dilation and not angiogenesis.
- The diagnosis of insulitis in human type 1 Diabetes.
- Bioluminescence Imaging Reveals Dynamics of Beta Cell Loss in the Non-Obese Diabetic (NOD) Mouse Model.
- A fall in portal vein insulin does not cause the alpha-cell response to mild, non-insulin-induced hypoglycemia in conscious dogs.
- Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines.
- Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets.
- Compartmentalization of transport and phosphorylation of glucose in a hepatoma cell line.
- Ascorbic acid recycling by cultured beta cells: effects of increased glucose metabolism.
- Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis.
- Diabetes referrals at a Veterans Administration tertiary facility: who are the patients and why are they referred?
- Factors influencing quantification of in vivo bioluminescence imaging: application to assessment of pancreatic islet transplants.
- Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging.
- Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy.
- Proteomic exploration of pancreatic islets in mice null for the alpha2A adrenergic receptor.
- Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene.
- A feasible approach to evaluate the relative reactivity of NHS-ester activated group With primary amine-derivatized DNA analogue and non-derivatized impurity.
- Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo?
- Generation of islet-like hormone-producing cells in vitro from adult human pancreas.
- Reovirus delays Diabetes onset but does not prevent insulitis in nonobese diabetic mice.
- A novel method of monitoring response to islet transplantation: bioluminescent imaging of an NF-kB transgenic mouse model.
- Current status of imaging pancreatic islets.
- Polymer scaffolds as synthetic microenvironments for extrahepatic islet transplantation.
- In vivo monitoring of pancreatic beta-cells in a transgenic mouse model.
- Complementation rescue of Pdx1 null phenoType demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression.
- Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function.
- Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells.
- Validation of luminescent source reconstruction using single-view spectrally resolved bioluminescence images.
- Glucose metabolism in vivo in four commonly used inbred mouse strains.
- Factor XI protein in human pancreas and kidney.
- Revascularization of transplanted islets: can it be improved?
- Insulin therapy versus cell-based therapy for type 1 Diabetes mellitus: what lies ahead?
- Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets.
- Molecular imaging of the pancreas in small animal models.
- Bioluminescence imaging in mouse models quantifies beta cell mass in the pancreas and after islet transplantation.
- PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression.
- Glucose-dependent blood flow dynamics in murine pancreatic islets in vivo.
- Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice.
- G?o represses insulin secretion by reducing vesicular docking in pancreatic beta-cells.
- Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.
- Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion.
- Pancreatic islet beta-cells transiently metabolize pyruvate.
- Assessment of insulin secretion in the mouse.
- Impact of medical student research in the development of physician-scientists.
- Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice.
- Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands.
- Humanized mice for the study of type 1 and type 2 Diabetes.
- Glucose uptake and metabolism by cultured human skeletal muscle cells: rate-limiting steps.
- Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization.
- Permeability assessment of capsules for islet transplantation.
- Coupling of glucose transport and phosphorylation in Xenopus oocytes and cultured cells: determination of the rate-limiting step.
- Transport and metabolism of glucose in an insulin-secreting cell line, beta TC-1.
- Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.
- Engineering physiologically regulated insulin secretion in non-beta cells by expressing glucagon-like peptide 1 receptor.
- An encapsulation system for the immunoisolation of pancreatic islets.
- Differential expression of glutamate receptor subTypes in rat pancreatic islets.
- Role of the C-terminal tail of the GLUT1 glucose transporter in its expression and function in Xenopus laevis oocytes.
- Glucose intolerance due to insulin resistance in patients With spinal cord injuries.
- Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets.
- Two regions of GLUT 2 glucose transporter protein are responsible for its distinctive affinity for glucose.
- New capsule With tailored properties for the encapsulation of living cells.
- Identification of glutamic acid decarboxylase autoantibody heterogeneity and epitope regions in type I Diabetes.
- A "cysteineless" GLUT1 glucose transporter has normal function when expressed in Xenopus oocytes.
- Different functional domains of GLUT2 glucose transporter are required for glucose affinity and substrate specificity.
- Glutamic acid decarboxylase autoantibodies in stiff-man syndrome and insulin-dependent Diabetes mellitus exhibit similarities and differences in epitope recognition.
- Non-Invasive Bioluminescence Imaging of β-Cell Function in Obese-Hyperglycemic [ob/ob] Mice.
- Proglucagon processing similar to normal islets in pancreatic alpha-like cell line derived from transgenic mouse tumor.
- Insulin degradation by mononuclear cells.
- Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel Diabetes-associated autoantigen.
- Expression of peptide hormone genes in human islet cell tumors.
- Sodium butyrate increases glucagon and insulin gene expression by recruiting immunocytochemically negative cells to produce hormone.
- Phospholipid and glutamic acid decarboxylase autoantibodies in diabetic neuropathy.
- Somatostatin gene expression in pancreatic islet cells is directed by cell-specific DNA control elements and DNA-binding proteins.
- Evaluation of microcapsule permeability via inverse size exclusion chromatography.
- Control and measurement of permeability for design of microcapsule cell delivery system.
- Comparative analysis of epitope recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different autoimmune Disorders.
- Gene-based neurotransmitter modulation in cerebellar granule neurons.
- Two distinct glutamic acid decarboxylase auto-antibody specificities in IDDM target different epitopes.
- Practical management of Diabetes in critically ill patients.
- Increased insulin-like growth factor II production and consequent suppression of growth hormone secretion: a dual mechanism for tumor-induced hypoglycemia.
- Murine monoclonal glutamic acid decarboxylase (GAD)65 antibodies recognize autoimmune-associated GAD epitope regions targeted in patients with type 1 Diabetes mellitus...
- Glucose transport activity and ligand binding (cytochalasin B, IAPS-forskolin) of chimeric constructs of GLUT2 and GLUT4 expressed in COS-7-cells.
- Characterization of monoclonal antibody 3G5 and utilization of this antibody to immobilize pancreatic islet cell gangliosides in a solid phase radioassay.
- Human B cells secreting immunoglobulin G to glutamic acid decarboxylase-65 from a nondiabetic patient With multiple autoantibodies and Graves' disease: a comparison wi...
- Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity.
- Prediabetic markers in children With stress hyperglycemia.
- Autoimmunity to islet cells in Diabetes mellitus.
- Unique strains of SV40 in commercial poliovaccines from 1955 not readily identifiable With current testing for SV40 infection.
- SV40 and the pathogenesis of mesothelioma.
- Enhancer and promoter element interactions dictate cyclic adenosine monophosphate mediated and cell-specific expression of the glycoprotein hormone alpha-gene.
- Intestinal absorption of immune complexes by neonatal rats: a route of antigen transfer from mother to young.
- Affordable Care Act Implementation: Challenges and Opportunities to Impact Patients With Diabetes.
Schools
University of Tennessee Memphis College of Medicine amp Surgery
Duke University Med Center
Joslin Diabetes Center
Massachusetts General Hospital
Conditions Treated
- Adrenal Incidentaloma
- Adrenal Insufficiency
- Craniopharyngioma
- Diabetes Type 1
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Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- America's Top Doctors
- Nashville Lifestyles Magazine
- Women's Health
- Men's Health
Education
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Massachusetts General Hospital -
Duke University Hospital -
University of Tennessee College of Medicine
Hospital
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Vanderbilt Hospital and Clinics -
Williamson Medical Center
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