William B. Knapp Professor of Medicine and Physiology
Cardiology
Dr. Allen M. Samarel, MD
|
|
Give Review
Allen Samarel is an expert in the field of Cardiology. He went to medical school at Harvard Medical School. Harvard Medical School is a top medical university. Harvard Medical School has a rank of 1 in research and a 12 in primary care Doctor Allen M. Samarel, MD has written publications. He has 101 publications published with PubMed. The lastest publication is: 'Identification of a contractile-responsive element in the cardiac alpha-myosin heavy chain gene.'
Publications
- Connective tissue growth factor regulates cardiac function and tissue remodeling in a mouse model of dilated cardiomyopathy.
- Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated c...
- Focal adhesion signaling in heart failure.
- Detection of differentially methylated gene promoters in failing and nonfailing human left ventricle myocardium using computation analysis.
- Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation.
- Regulation of connective tissue growth factor gene expression and fibrosis in human heart failure.
- Syndecan-4: A component of the mechanosensory apparatus of cardiac fibroblasts.
- Talin1 Has Unique Expression versus Talin 2 in the Heart and Modifies the Hypertrophic Response to Pressure Overload.
- Chronic fluoxetine reduces autonomic control of cardiac rhythms in rats with congestive heart failure.
- Microdomain heterogeneity in 3D affects the mechanics of neonatal cardiac myocyte contraction.
- Contractile Activity Regulates Inducible Nitric Oxide Synthase Expression and NO(i) Production in Cardiomyocytes via a FAK-Dependent Signaling Pathway.
- Serine 910 Phosphorylation of Focal Adhesion Kinase is Critical for Sarcomere Reorganization In Cardiomyocyte Hypertrophy.
- Focal Adhesion Kinase-Related Nonkinase Inhibits Vascular Smooth Muscle Cell Invasion by Focal Adhesion Targeting, Tyrosine 168 Phosphorylation, and Competition for p1...
- Protein Kinase C-{varepsilon} Activation Induces Mitochondrial Dysfunction and Mitochondrial Fragmentation in Renal Proximal Tubules.
- Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes.
- FRNK inhibition of focal adhesion kinase-dependent signaling and migration in vascular smooth muscle cells.
- CapZ dynamics are altered by endothelin-1 and phenylephrine via PIP2- and PKC-dependent mechanisms.
- Physiological replacement of T3 improves left ventricular function in an animal model of myocardial infarction-induced congestive heart failure.
- PICOT: a multidomain scaffolding inhibitor of hypertrophic signal transduction.
- A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2.
- Deoxycholic acid differentially regulates focal adhesion kinase phosphorylation: role of tyrosine phosphatase ShP2.
- Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability.
- Phosphorylation and binding of AUF1 to the 3'-untranslated region of cardiomyocyte SERCA2a mRNA.
- Costameres, focal adhesions, and cardiomyocyte mechanotransduction.
- Distinct pathways regulate expression of cardiac electrical and mechanical junction proteins in response to stretch.
- PYK2 regulates SERCA2 gene expression in neonatal rat ventricular myocytes.
- Protein kinase C-alpha-induced hypertrophy of neonatal rat ventricular myocytes.
- Restoration of resting sarcomere length after uniaxial static strain is regulated by protein kinase Cepsilon and focal adhesion kinase.
- Activation of focal adhesion kinase by protein kinase C epsilon in neonatal rat ventricular myocytes.
- Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and...
- Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a prot...
- Isoenzyme-selective regulation of SERCA2 gene expression by protein kinase C in neonatal rat ventricular myocytes.
- PYK2 expression and phosphorylation increases in pressure overload-induced left ventricular hypertrophy.
- GFP-FRNK disrupts focal adhesions and induces anoikis in neonatal rat ventricular myocytes.
- Targeted myocardial transgenic expression of HIV Tat causes cardiomyopathy and mitochondrial damage.
- IGF-1 Overexpression rescues the failing heart.
- Agranulocytosis associated with aprindine therapy.
- Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy.
- Protein kinase C epsilon-dependent activation of proline-rich tyrosine kinase 2 in neonatal rat ventricular myocytes.
- A role for proteinase-activated receptor 2 and PKC-epsilon in thrombin-mediated induction of decay-accelerating factor on human endothelial cells.
- PKCepsilon induces astrocyte stellation by modulating multiple cytoskeletal proteins and interacting with Rho A signalling pathways: implications for neuroinflammation.
- Signalling mechanisms in contraction-mediated stimulation of intracellular NO production in cat ventricular myocytes.
- Protein kinase Cepsilon-dependent MARCKS phosphorylation in neonatal and adult rat ventricular myocytes.
- Beta(1)-integrins modulate beta-adrenergic receptor signaling.
- An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic.
- Laminin acts via focal adhesion kinase/phosphatidylinositol-3'' kinase/protein kinase B to down-regulate beta1-adrenergic receptor signalling in cat atrial myocytes.
- CRNK gene transfer improves function and reverses the myosin heavy chain isoenzyme switch during post-myocardial infarction left ventricular remodeling.
- Persistent alterations in heart rate variability, baroreflex sensitivity, and anxiety-like behaviors during development of heart failure in the rat.
- Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: roles of Ras, p38, and CCAAT/enhancer-binding protein.
- Role of FRNK tyrosine phosphorylation in vascular smooth muscle spreading and migration.
- Laminin enhances beta(2)-adrenergic receptor stimulation of L-type Ca(2+) current via cytosolic phospholipase A(2) signalling in cat atrial myocytes.
- FRNK overexpression limits the depth and frequency of vascular smooth muscle cell invasion in a three-dimensional fibrin matrix.
- Mechanical stress-induced sarcomere assembly for cardiac muscle growth in length and width.
- Identification of a contractile-responsive element in the cardiac alpha-myosin heavy chain gene.
- Prolyl hydroxylation regulates intracellular procollagen degradation in cultured rat cardiac fibroblasts.
- Contractile activity modulates actin synthesis and turnover in cultured neonatal rat heart cells.
- Hemodynamic overload and the regulation of myofibrillar protein degradation.
- Cyclosporine A has no direct effect on collagen metabolism by cardiac fibroblasts in vitro.
- Regulation of procollagen metabolism in the pressure-overloaded rat heart.
- Formation of fetal rat cardiac cell clones by retroviral transformation: retention of select myocyte characteristics.
- Catecholamines modulate protein turnover in cultured, quiescent rabbit cardiac myocytes.
- Contractile arrest increases sarcoplasmic reticulum calcium uptake and SERCA2 gene expression in cultured neonatal rat heart cells.
- Regulation of rat ventricular myosin heavy chain expression by serum and contractile activity.
- Histomorphometric and biochemical correlates of arterial procollagen gene expression during vascular repair after experimental angioplasty.
- Mechanical regulation of cardiac myofibrillar structure.
- Rabbit cardiac immunoreactive cathepsin D content during starvation-induced atrophy.
- A double antibody radioimmunoassay for canine cardiac cathepsin D.
- Regulation of cathepsin D metabolism in rabbit heart: evidence for a role for precursor processing in the control of enzyme activity.
- Determination of 35S-aminoacyl-transfer ribonucleic acid specific radioactivity in small tissue samples.
- Susceptibilities of cardiac myofibrillar proteins to cathepsin D-catalyzed degradation.
- Primary structure similarities in canine cardiac cathepsin D polypeptide chains.
- Biosynthesis of the multiple forms of rabbit cardiac cathepsin D.
- Release of unassembled rat cardiac myosin light chain 1 following the calcium paradox.
- Identification of artifactual cathepsin D activity in cardiac subcellular fractions related to formation of an iron-EDTA complex.
- Transport and proteolytic processing of rabbit cardiac cathepsin D.
- Quantitative analysis of myofibrillar protein subunits: demonstration of large molar excesses of myosin light chains in rabbit ventricular myocardium.
- Protein synthesis and degradation during starvation-induced cardiac atrophy in rabbits.
- Nonrandom turnover of actin and tubulin in cultured rabbit cardiac fibroblasts.
- Attachment and maintenance of adult rabbit cardiac myocytes in primary cell culture.
- Lysosomal changes during thyroxine-induced left ventricular hypertrophy in rabbits.
- Cardiac protein synthesis and degradation during thyroxine-induced left ventricular hypertrophy.
- Regional differences in the in vivo synthesis and degradation of myosin subunits in rabbit ventricular myocardium.
- Effects of cysteine protease inhibitors on rabbit cathepsin D maturation.
- Protein synthesis and degradation during regression of thyroxine-induced cardiac hypertrophy.
- Regional differences in in vivo myocardial protein synthesis in the neonatal rabbit heart.
- In vivo measurements of protein turnover during muscle growth and atrophy.
- Asparaginyl deamidation-methylation of rat ventricular myosin light chains.
- In vivo collagen turnover during development of thyroxine-induced left ventricular hypertrophy.
- Hemodynamic regulation of myosin heavy chain gene expression. Studies in the transplanted rat heart.
- Contractile activity modulates myosin heavy chain-beta expression in neonatal rat heart cells.
- Heterotopic cardiac transplantation decreases the capacity for rat myocardial protein synthesis.
- Thyroid hormone effects on cardiac gene expression independent of cardiac growth and protein synthesis.
- Contractile arrest accelerates myosin heavy chain degradation in neonatal rat heart cells.
- Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice.
- Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase C epsilon and delta in neonatal rat ventricular myocytes.
- Gq-coupled receptor signaling in pathological ventricular remodeling.
- Pyk2 expression and phosphorylation in neonatal and adult cardiomyocytes.
- Role of protein kinase C-epsilon in hypertrophy of cultured neonatal rat ventricular myocytes.
- Brief rapid pacing depresses contractile function via Ca(2+)/PKC-dependent signaling in cat ventricular myocytes.
- Focal adhesion kinase is involved in angiotensin II-mediated protein synthesis in cultured vascular smooth muscle cells.
Schools
Harvard Medical School
Doctors Specialties
- Cardiology
Accepted Insurances
Education
-
McGaw Medical Center of Northwestern University -
Mount Sinai School of Medicine -
Harvard Medical School
Helpful Reviews
Similar Doctors
|
|
Dr. Mark Rabbat, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Joseph Cytron, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Max Liebo, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Khaled Dajani, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Michael J. Ryan, MD |
|
|
Dr. Christopher A. Henry, MD |
|
|
Dr. Kim H. Chan, MD |