Physician
Internal Medicine
Dr. Alfred Singer, MD
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Alfred Singer practices Internal Medicine. He received 1 awards: "Whos Who in Medicine and Healthcare". Alfred Singer is a published physician. He has 10 papers published. The most current publication "T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1."
Publications
- The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling.
- Regulation of MHC Class I Expression by Foxp3 and Its Effect on Regulatory T Cell Function.
- Basis of Treg development in the thymus.
- Lck Availability during Thymic Selection Determines the Recognition Specificity of the T Cell Repertoire.
- IL-7 signaling must be intermittent, not continuous, during CD8(+) T cell homeostasis to promote cell survival instead of cell death.
- MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection.
- Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.
- Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic.
- T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1.
Schools
Columbia University College of Physicians And Surgeons
Doctors Specialties
- Internal Medicine
Accepted Insurances
Awards
- Whos Who in Medicine and Healthcare
Education
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New York Presbyterian Hospital - Columbia Campus
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