Professor of Surgery, University Mich Medical School
General Surgery
Dr. Alfred E. Chang, MD
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Alfred Chang works in the field of General Surgery. He graduated from Harvard Medical School. Harvard Medical School is a one of the best medicals schools. Harvard Medical School is ranked 1 in research and 12 in primary care medicine He has 5 awards "America's Top Doctors", "America's Top Doctors for Cancer", "CMS Meaningful Use Stage 1 Certification", "Redbook Magazine: Top Breast Cancer Doctors" and "Fellow (FACS)". Alfred Chang is also a published physician. He has 88 paper published. The most recent paper is: A phase I clinical trial utilizing autologous tumor-infiltrating lymphocytes in patients with primary hepatocellular carcinoma. Doctor Alfred E. Chang, MD is registered with Medicare.
Publications
- A phase I clinical trial utilizing autologous tumor-infiltrating lymphocytes in patients with primary hepatocellular Carcinoma.
- Antitumor effector B cells directly kill tumor cells via the Fas/FasL pathway and are regulated by IL-10.
- Activating STAT6 mutations in follicular lymphoma.
- Mutations in linker histone genes HIST1H1 B, C, D and E, OCT2 (POU2F2), IRF8 and ARID1A underlying the pathogenesis of follicular lymphoma.
- OK-432 synergizes with IFN-γ to confer dendritic cells with enhanced antitumor immunity.
- IL-17A Promotes Immune Cell Recruitment in Human Esophageal Cancers and the Infiltrating Dendritic Cells Represent a Positive Prognostic Marker for Patient Survival.
- Cancer immunotherapy: current status and future directions.
- Effects of tumor irradiation on host T-regulatory cells and systemic immunity in the context of adoptive T-cell therapy in mice.
- Targeting Cancer stem cells via dendritic-cell vaccination.
- Interleukin-6 Inhibits Regulatory T Cells and Improves the Proliferation and Cytotoxic Activity of Cytokine-induced Killer Cells.
- Is Duct Excision Still Necessary for All Cases of Suspicious Nipple Discharge?
- Defining the Critical Hurdles in Cancer Immunotherapy.
- B lymphocytes as effector cells in the immunotherapy of Cancer.
- Is a level III Dissection necessary for a positive sentinel lymph node in melanoma?
- Validation of Statistical Predictive Models Meant to Select Melanoma Patients for Sentinel Lymph Node Biopsy.
- Adoptive transfer of tumor reactive B cells confers host T cell immunity and tumor regression.
- Surgical options for localized and advanced gastroIntestinal stromal tumors.
- Rate of freeze alters the immunologic response after cryoablation of breast Cancer.
- From the guest editors: introduction to local therapies in the treatment of liver Cancer.
- Is there a benefit to sentinel lymph node biopsy in patients with T4 melanoma?
- Gemcitabine-based combination chemotherapy followed by radiation with capecitabine as adjuvant therapy for resected pancreas Cancer.
- Prognostic significance of a positive nonsentinel lymph node in cutaneous melanoma.
- In vivo sensitized and in vitro activated B cells mediate tumor regression in Cancer adoptive immunotherapy.
- Radiotherapy combined with intratumoral dendritic cell vaccination enhances the therapeutic efficacy of adoptive T-cell transfer.
- Residual disease after re-excision Lumpectomy for close margins.
- Determinants of breast conservation rates: reasons for mastectomy at a comprehensive Cancer center.
- Dendritic cells pulsed with keyhole limpet hemocyanin and cryopreserved maintain anti-tumor activity in a murine melanoma model.
- Axillary staging prior to neoadjuvant chemotherapy for breast Cancer: predictors of recurrence.
- Intratumoral dendritic cells and chemoradiation for the treatment of murine squamous cell Carcinoma.
- Do micromorphometric features of metastatic deposits within sentinel nodes predict nonsentinel lymph node involvement in melanoma?
- Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta.
- Phase Ib trial assessing autologous, tumor-pulsed dendritic cells as a vaccine administered with or without IL-2 in patients with metastatic melanoma.
- Interleukin-21 augments the efficacy of T-cell therapy by eliciting concurrent cellular and humoral responses.
- Mechanisms involved in radiation enhancement of intratumoral dendritic cell therapy.
- Sentinel lymph node biopsy for breast Cancer: how many nodes are enough?
- Generation of a tumor-specific systemic response after intratumoral injection of IL-12 and IL-18-loaded polylactic acid microspheres.
- Synergistic effect of intratumoral IL-12 and TNF-alpha microspheres: systemic anti-tumor immunity is mediated by both CD8+ CTL and NK cells.
- The registry case finding engine: an automated tool to identify Cancer cases from unstructured, free-text pathology reports and clinical notes.
- Phase I study of oxaliplatin, full-dose gemcitabine, and concurrent radiation therapy in pancreatic Cancer.
- Sentinel lymph node biopsy performed after neoadjuvant chemotherapy is accurate in patients with documented node-positive breast Cancer at presentation.
- CCL19 and CXCL13 synergistically regulate interaction between B cell acute lymphocytic leukemia CD23+CD5+ B Cells and CD8+ T cells.
- What is a sentinel node? Re-evaluating the 10% rule for sentinel lymph node biopsy in melanoma.
- Radiation-induced apoptosis along with local and systemic cytokine elaboration is associated with DC plus radiotherapy-mediated renal cell tumor regression.
- Inguinal node Dissection for melanoma in the era of sentinel lymph node biopsy.
- 4-1BB costimulation of effector T cells for adoptive immunotherapy of Cancer: involvement of Bcl gene family members.
- Improving surgical outcomes for Cancer in the United States.
- The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanoma.
- Adoptive immunotherapy of breast Cancer with lymph node cells primed by cryoablation of the primary tumor.
- Changes in surgical management resulting from case review at a breast Cancer multidisciplinary tumor board.
- CXC chemokine ligand 13 and CC chemokine ligand 19 cooperatively render resistance to apoptosis in B cell lineage acute and chronic lymphocytic leukemia CD23+CD5+ B ce...
- Neoadjuvant intratumoral cytokine-loaded microspheres are superior to postoperative autologous cellular vaccines in generating systemic anti-tumor immunity.
- Significance of multiple lymphatic basin drainage in truncal melanoma patients undergoing sentinel lymph node biopsy.
- Ex vivo culture with interleukin (IL)-12 improves CD8(+) T-cell adoptive immunotherapy for murine leukemia independent of IL-18 or IFN-gamma but requires perforin.
- Does the method of biopsy affect the incidence of sentinel lymph node metastases?
- Lymphatic mapping and sentinel lymph node biopsy for patients with local recurrence after Breast-conservation therapy.
- Clinicopathologic features associated with having four or more metastatic axillary nodes in breast Cancer patients with a positive sentinel lymph node.
- Capecitabine and radiation therapy preceded and followed by combination chemotherapy in advanced pancreatic Cancer.
- Wide excision without radiation for desmoplastic melanoma.
- Comprehensive axillary evaluation in neoadjuvant chemotherapy patients with ultrasonography and sentinel lymph node biopsy.
- Is blue dye indicated for sentinel lymph node biopsy in breast Cancer patients with a positive lymphoscintigram?
- Simultaneous targeting of CD3 on T cells and CD40 on B or dendritic cells augments the antitumor reactivity of tumor-primed lymph node cells.
- Predictors of nonsentinel lymph node positivity in patients with a positive sentinel node for melanoma.
- Synergistic effects of IL-12 and IL-18 in skewing tumor-reactive T-cell responses towards a type 1 pattern.
- Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines.
- An academic health center cost Analysis of screening mammography: creating a financially viable service.
- Mastectomy and concomitant sentinel lymph node biopsy for invasive breast Cancer.
- Efficacy of sentinel lymph node biopsy in male breast Cancer.
- Donor cell cycling, trafficking, and accumulation during adoptive immunotherapy for murine Lung metastases.
- Mitotic rate and younger age are predictors of sentinel lymph node positivity: lessons learned from the generation of a probabilistic model.
- Exaggerated pigmented granulomatous reaction to the artificial joint implant mimics metastatic melanoma.
- Intratumoral IL-12 and TNF-alpha-loaded microspheres lead to regression of breast Cancer and systemic antitumor immunity.
- Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration.
- Clinicopathologic features of metastasis in nonsentinel lymph nodes of Breast carcinoma patients.
- Sentinel node biopsy prior to neoadjuvant chemotherapy.
- Polarization effects of 4-1BB during CD28 costimulation in generating tumor-reactive T cells for Cancer immunotherapy.
- Antitumor reactivity of anti-CD3/anti-CD28 bead-activated lymphoid cells: implications for cell therapy in a murine model.
- Generation of vaccine-primed lymphocytes for the treatment of head and neck Cancer.
- Phase II trial of autologous tumor vaccination, anti-CD3-activated vaccine-primed lymphocytes, and interleukin-2 in stage IV renal cell Cancer.
- Melanoma and human leukocyte antigen status: the missing link?
- Applications of gene transfer to cellular immunotherapy.
- Mammographic screening of TRAM flap breast reconstructions for detection of nonpalpable recurrent Cancer.
- Therapeutic effects of tumor reactive CD4+ cells generated from tumor-primed lymph nodes using anti-CD3/anti-CD28 monoclonal antibodies.
- A phase I trial of tumor lysate-pulsed dendritic cells in the treatment of advanced Cancer.
- Comparison of attenuation-corrected and non-corrected FDG-PET images for axillary nodal staging in newly diagnosed breast Cancer.
- Generation of a novel dendritic-cell vaccine using melanoma and squamous Cancer stem cells.
- A nomogram for predicting the benefit of adjuvant cytokine-induced killer cell immunotherapy in patients with hepatocellular Carcinoma.
- Characterization of a Novel Transgenic Mouse Tumor Model for Targeting HER2+ Cancer Stem Cells.
Schools
Harvard Medical School
Duke University Med Center
Hospital Of The University Of Pennsylvania
National Cancer Institute
Procedures Preformed
- Adrenalectomy
- Appendectomy, Laparoscopic
- Biopsy of Breast
- Breast Reconstruction
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Conditions Treated
- Abdominal Pain
- Adrenal Gland Cancer
- Anal and Rectal Cancer
- Atelectasis
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Doctors Specialties
- General Surgery
Accepted Insurances
Awards
- America's Top Doctors
- America's Top Doctors for Cancer
- CMS Meaningful Use Stage 1 Certification
- Redbook Magazine: Top Breast Cancer Doctors
- Fellow (FACS)
Education
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University of Pennsylvania Health System -
Duke University Hospital -
Harvard Medical School
Hospital
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University of Michigan Hospitals and Health Centers
Drug Facts
| NPI NUMBER | 1104924372 | |
| NPPES Provider LastName | CHANG | |
| NPPES Provider FirstName | ALFRED | |
| NPPES Provider ZIPCode | 481095916 | |
| NPPES Provider State | MI | |
| Specialty Description | General Surgery | |
| Total Claim Count | 118.0 | |
| Distinct Opioid Count | 1.0 | |
| Opioid Claim Count | 18.0 | |
| Percent Opioid Claims | 15.25 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1104924372 |
| Last Name Of The Provider | CHANG |
| First Name Of The Provider | ALFRED |
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