Professor, Surgery, University of Washington School of Medicine

General Surgery

Doctor Alexander W. Clowes, MD practices General Surgery. He received awards:"Fellow (FACS)". Alexander Clowes is a published doctor and has 46 publications published. The lastest was: 'Tissue Factor Activity in Dialysis AccessGrafts.'

Publications

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• Efficient Gene Transfer and Durable Transgene Expression in Grafted Rabbit Veins.
• Low levels of a natural IgM antibody are associated with Vein graft stenosis and failure.
• VASP increases hepatic fatty acid oxidation by activating AMPK in mice.
• Endothelial NO/cGMP/VASP Signaling Attenuates Kupffer Cell Activation and Hepatic Insulin Resistance Induced by High-Fat Feeding.
• Reduced Vascular Nitric Oxide-cGMP Signaling Contributes to Adipose Tissue Inflammation During High-Fat Feeding.
• A link between smooth muscle cell death and extracellular matrix degradation during Vascular atrophy.
• VASP phosphorylation at serine239 regulates the effects of NO on smooth muscle cell invasion and contraction of collagen.
• Cell death-associated ADAMTS4 and versican degradation in Vascular tissue.
• Syndecan-1: an inhibitor of Arterial smooth muscle cell growth and intimal hyperplasia.
• Proliferative capacity of Vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis.
• Disparity in outcomes of surgical revascularization for limb salvage: race and gender are synergistic determinants of Vein graft failure and limb loss.
• Retrovirally mediated overexpression of glycosaminoglycan-deficient biglycan in Arterial smooth muscle cells induces tropoelastin synthesis and elastic fiber formation...
• Twentieth anniversary of American Vascular Association/Lifeline Foundation: a celebration.
• Effects of external wrapping and increased blood flow on atrophy of the baboon iliac Artery.
• Induction of Vascular atrophy as a novel approach to treating restenosis. A review.
• Female gender and oral anticoagulants are associated with wound complications in lower extremity Vein bypass: an analysis of 1404 operations for critical limb ischemia.
• Technical factors affecting autogenous Vein graft failure: observations from a large multicenter trial.
• Surgical and endovascular revision of infrainguinal Vein bypass grafts: analysis of midterm outcomes from the PREVENT III trial.
• Reviving the Vascular surgeon-scientist: an interim assessment of the jointly sponsored Lifeline Foundation/National Heart, Lung, and Blood Institute William J. von Li...
• Resource utilization in the treatment of critical limb ischemia: The effect of tissue loss, comorbidities, and graft-related events.
• Dacron patch infection after Carotid endarterectomy: case report and review of the literature.
• Images in cardioVascular medicine. Serial high-spatial-resolution, multisequence magnetic resonance imaging studies identify fibrous cap rupture and penetrating ulcer ...
• Inhibition of versican synthesis by antisense alters smooth muscle cell phenotype and induces elastic fiber formation in vitro and in neointima after vessel injury.
• Bone morphogenetic protein 4: potential regulator of shear stress-induced graft neointimal atrophy.
• Platelet-derived growth factor-BB transactivates the fibroblast growth factor receptor to induce proliferation in human smooth muscle cells.
• Risk factors, medical therapies and perioperative events in limb salvage surgery: observations from the PREVENT III multicenter trial.
• Syndecan-4 is required for thrombin-induced migration and proliferation in human Vascular smooth muscle cells.
• Commentary. Circulating monocytes and in-stent neointima after coronary stent implantation.
• Platelet-derived growth factor-BB-induced human smooth muscle cell proliferation depends on basic FGF release and FGFR-1 activation.
• Accumulation and loss of extracellular matrix during shear stress-mediated intimal growth and regression in baboon Vascular grafts.
• Design and rationale of the PREVENT III clinical trial: edifoligide for the prevention of infrainguinal Vein graft failure.
• Vasodilator-stimulated phosphoprotein regulates proliferation and growth inhibition by nitric oxide in Vascular smooth muscle cells.
• Pharmacologic inhibition of nitric oxide synthases and cyclooxygenases enhances intimal hyperplasia in balloon-injured rat Carotid arteries.
• Arterial injury repair in nonhuman primates-the role of PDGF receptor-beta.
• Interleukin-1beta inhibits PDGF-BB-induced migration by cooperating with PDGF-BB to induce cyclooxygenase-2 expression in baboon Aortic smooth muscle cells.
• Cleavage of focal adhesion kinase in Vascular smooth muscle cells overexpressing membrane-type matrix metalloproteinases.
• Thrombin- and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human Vascular smooth muscle cells.
• Concomitant blockade of platelet-derived growth factor receptors alpha and beta induces intimal atrophy in baboon PTFE grafts.
• Blockade of the epidermal growth factor receptor decreases intimal hyperplasia in balloon-injured rat Carotid artery.
• The prevalence and natural history of aortic aneurysms in heart and Abdominal organ transplant patients.
• Flow-induced neointimal regression in baboon polytetrafluoroethylene grafts is associated with decreased cell proliferation and increased apoptosis.
• Interleukin-1beta inhibits expression of p21(WAF1/CIP1) and p27(KIP1) and enhances proliferation in response to platelet-derived growth factor-BB in smooth muscle cells.
• Retrovirally mediated overexpression of versican v3 by Arterial smooth muscle cells induces tropoelastin synthesis and elastic fiber formation in vitro and in neointim...
• Increased plasmin and serine proteinase activity during flow-induced intimal atrophy in baboon PTFE grafts.
• Tissue Factor Activity in Dialysis Access Grafts.

Schools

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• Harvard Medical School

• University Hosps

• Peter B Brigham Hospital

Procedures Preformed

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• Aortic Repair, Open or Repair of Arterial Aneurysm, Open
• Carotid Endarterectomy (CEA) or Excision of Infected Graft
• Dressing and-or Debridement of Wound, Infection, or Burn (incl. Negative Pressure Wound Therapy)
• Embolectomy, Thrombectomy, or Vessel Exploration
• View All

Conditions Treated

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• Abdominal Aortic Aneurysm (AAA)
• Aortic Aneurysm
• Aortic Dissection
• Aortic Ectasia
• View All

Doctors Specialties

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• General Surgery
• Vascular Surgery

Accepted Insurances

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Awards

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• Fellow (FACS)

Hospital

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• UW Medicine/Harborview Medical Center
• University of Washington Medical Center

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