Associate Professor, Orthopaedic Surgery, University of Arizona College of Medicine

Orthopaedic Surgery

Alexander McLaren works in the field of Orthopaedic Surgery. Alexander McLaren is a published MD. He has 33 publications published. The most current publication "Salvage of infected total knee components."

Publications

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• Liposomal Formulation Decreases Toxicity of Amphotericin B In Vitro and In Vivo.
• Antimicrobial Release From Prefabricated Spacers Is Variable and the Dose Is Low.
• Local Gentamicin Delivery From Resorbable Viscous Hydrogels Is Therapeutically Effective.
• Biofilm Growth Has a Threshold Response to Glucose in Vitro.
• Antimicrobial Distribution From Local Delivery Depends on Dose : A Pilot Study With MRI.
• Distribution of molecules locally delivered from bone cement.
• Have Levels of Evidence Improved the Quality of Orthopaedic Research?
• Voriconazole Is Cytotoxic at Locally Delivered Concentrations: A Pilot Study.
• Distribution of Locally Delivered Antimicrobials Is Limited by Cortical Bone: A Pilot Study.
• Voriconazole is delivered from antifungal-loaded bone cement.
• Jeannette Wilkins Award: Can Locally Delivered Gadolinium Be Visualized on MRI? A Pilot Study.
• Surfactant-stabilized Emulsion Increases Gentamicin Elution From Bone Cement.
• Amphotericin B Delivery From Bone Cement Increases With Porosity but Strength Decreases.
• Amphotericin B Is Cytotoxic at Locally Delivered Concentrations.
• Hand-mixed and premixed antibiotic-loaded bone cement have similar homogeneity.
• Sucrose, xylitol, and erythritol increase PMMA permeability for depot antibiotics.
• Xylitol and glycine fillers increase permeability of PMMA to enhance elution of daptomycin.
• Phenolphthalein used to assess permeability of antibiotic-laden polymethylmethacrylate: a pilot study.
• Is aseptic loosening truly aseptic?
• The effect of glycine filler on the elution rate of gentamicin from acrylic bone cement: a pilot study.
• Alternative materials to acrylic bone cement for delivery of depot antibiotics in orthopaedic infections.
• The effect of sampling method on the elution of tobramycin from calcium sulfate.
• Spatiotemporal quantification of local drug delivery using MRI.
• A virtual reality simulator for orthopedic basic skills: a design and validation study.
• Cauda equina syndrome: a complication of lumbar discectomy.
• Anterolateral compression fracture of the thoracolumbar spine. A seat belt injury.
• Locked intramedullary fixation for metaphyseal malunion and nonunion.
• Open reduction internal fixation of supracondylar fractures above total knee arthroplasties using the intramedullary supracondylar rod.
• Salvage of infected total knee components.
• Generic tobramycin elutes from bone cement faster than proprietary tobramycin.
• Strength of antimicrobial bone cement decreases with increased poragen fraction.
• Particle size of fillers affects permeability of polymethylmethacrylate.

Doctors Specialties

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• Orthopedic Surgery
• Orthopaedic Surgery

Accepted Insurances

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Education

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• Queen's University at Kingston

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