Henry Mallinckrodt Professor of Anesthesiology, Developmental Biology and Internal Medicine Washington University in St. Louis Anesthesiologist-in-Chief Barnes-Jewish Hospital
Anesthesiology
Dr. Alex S. Evers, MD
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Alex Evers is an expert in the field of Anesthesiology. He studied medicine at NYU School of Medicine. He over the years received 3 awards: "Elected Member", "Top MD" and "Whos Who in Medicine and Healthcare". Dr. Alex S. Evers is a published doctor and has 83 publications published. The lastest was: 'Double-edged swords: volatile anesthetics both enhance and inhibit ligand-gated ion channels.'
Publications
- Persistent Postoperative Cognitive Decline?: The Pyramid of Evidence.
- The Fallacy of Persistent Postoperative Cognitive Decline.
- Anesthetic neurotoxicity--clinical implications of animal models.
- The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors.
- 11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.
- Neurosteroid Analogues. 18. Structure-Activity Studies of ent-Steroid Potentiators of γ-Aminobutyric Acid Type A Receptors and Comparison of Their Activities with Thos...
- Neurosteroid Analogues. 17. Inverted Binding Orientations of Androsterone Enantiomers at the Steroid Potentiation Site on ?-Aminobutyric Acid Type A Receptors.
- Ketamine-induced Neuroapoptosis in the Fetal and Neonatal Rhesus Macaque Brain.
- Relationship between Bispectral Index Values and Volatile Anesthetic Concentrations during the Maintenance Phase of Anesthesia in the B-Unaware Trial.
- Memories and Dreams: Building an Academic Department at Washington University in St. Louis.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Characteristics of ?4/?-containing concatemeric GABA(A) receptors expressed in Xenopus oocytes.
- Congratulations from the IARS!
- Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic...
- Postoperative cognitive decline: the unsubstantiated phenotype.
- Leadership in postgraduate medical education.
- A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors.
- Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain.
- Long-term cognitive decline in older subjects was not attributable to noncardiac surgery or major illness.
- Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors.
- Performance of certified registered nurse anesthetists and anesthesiologists in a simulation-based skills assessment.
- Anesthesia awareness and the bispectral index.
- Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes.
- Performance of residents and anesthesiologists in a simulation-based skill assessment.
- Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis.
- Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light.
- Can we get there if we don't know where we're going?
- Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the alpha1beta2gamma2L GABAA receptor.
- Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes.
- Intrapatient reproducibility of the BISxp monitor.
- Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and ...
- Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors.
- Isoflurane inhibits transmitter release and the presynaptic action potential.
- Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia.
- Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and an...
- Mervyn Maze, M.B., Ch.B., F.R.C.P.: recipient of the 2003 Excellence in Research Award.
- Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain.
- Effects on gamma-aminobutyric acid (GABA)(A) receptors of a neuroactive steroid that negatively modulates glutamate neurotransmission and augments GABA neurotransmission.
- Enantioselectivity of steroid-induced gamma-aminobutyric acidA receptor modulation and anesthesia.
- Steroid inhibition of rat neuronal nicotinic alpha4beta2 receptors expressed in HEK 293 cells.
- Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetate.
- Neuroactive steroids have multiple actions to potentiate GABAA receptors.
- Relevant concentrations of inhaled anesthetics for in vitro studies of anesthetic mechanisms.
- Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3alpha, 5alpha)- and (3alpha,5beta)-3-h...
- Direct observation of a fluorinated anticonvulsant in brain tissue using 19F-NMR techniques.
- Isoflurane uptake and elimination are delayed by absorption of anesthetic by the Scimed membrane oxygenator.
- Recent developments in structure-activity relationships for steroid modulators of GABA(A) receptors.
- Postoperative cognitive dysfunction: overinterpretation of data?
- Elimination kinetics of sevoflurane and halothane from blood, brain, and adipose tissue in the rat.
- Volatile anesthetic-induced efflux of calcium from IP3-gated stores in clonal (GH3) pituitary cells.
- 19F-NMR spin-spin relaxation (T2) method for characterizing volatile anesthetic binding to proteins. Analysis of isoflurane binding to serum albumin.
- Volatile anesthetic effects on inositol trisphosphate-gated intracellular calcium stores in GH3 cells.
- Volatile anesthetics compete for common binding sites on bovine serum albumin: a 19F-NMR study.
- Supersensitive sites in the central nervous system. Anesthetics block brain nicotinic receptors.
- Postanesthesia care unit length of stay: quantifying and assessing dependent factors.
- Double-edged swords: volatile anesthetics both enhance and inhibit ligand-gated ion channels.
- Impact of anesthesia management characteristics on severe morbidity and mortality: are we convinced?
- 19F-nuclear magnetic resonance spectroscopy. Its use in defining molecular sites of anesthetic action.
- The potency of fluorinated ether anesthetics correlates with their 19F spin-spin relaxation times in brain tissue.
- Halothane inhibits two components of calcium current in clonal (GH3) pituitary cells.
- The action of halothane on stimulus-secretion coupling in clonal (GH3) pituitary cells.
- Altered phosphoinositide fatty acid composition, mass and metabolism in brain essential fatty acid deficiency.
- Manipulation of rat brain fatty acid composition alters volatile anesthetic potency.
- Anion exchange chromatographic separation of inositol phosphates and their quantification by gas chromatography.
- Role of invading leukocytes in enhanced atrial eicosanoid production following rabbit left ventricular myocardial infarction.
- Enhanced inositol trisphosphate response to alpha 1-adrenergic stimulation in cardiac myocytes exposed to hypoxia.
- Anesthesia and chemical second messenger generation in the adrenergic nervous system.
- fMet-Leu-Phe receptor expression by an interstitial cell in rabbit right atrium following left ventricular myocardial infarction.
- Effect of endogenously produced leukotrienes and thromboxane on renal vascular resistance in rabbit hydronephrosis.
- Management of the postpubertal patient with cryptorchidism: an updated analysis.
- Successful treatment of accelerated junctional rhythm with propranolol: possible role of sympathetic stimulation in the genesis of this rhythm disturbance.
- Deep amino acid sequencing of native brain GABAA receptors using high-resolution mass spectrometry.
- Perspective: hospital support for anesthesiology departments: aligning incentives and improving productivity.
- Prevention of intraoperative awareness in a high-risk surgical population.
- Review of clinical evidence for persistent cognitive decline or incident dementia attributable to surgery or general anesthesia.
- Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids.
- Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues.
- The influence of the membrane on neurosteroid actions at GABA(A) receptors.
- Mechanisms of neurosteroid interactions with GABA(A) receptors.
- Potential of xenon to induce or to protect against neuroapoptosis in the developing mouse brain.
- Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens.
- Enantioselectivity of pregnanolone-induced gamma-aminobutyric acid(A) receptor modulation and anesthesia.
Schools
New York University
Michael Reese Hospital and Med Center
Massachusetts General Hospital
Michael Reese
Doctors Specialties
- Critical Care Medicine
- Anesthesiology
Accepted Insurances
Awards
- Elected Member
- Top MD
- Whos Who in Medicine and Healthcare
Education
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Massachusetts General Hospital -
NYU School of Medicine
Hospital
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Barnes-Jewish Hospital -
St. Louis Children's Hospital
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