Assistant Professor of Radiation Oncology, Brigham and Women's Hospital
Radiation Oncology
Dr. Alec C. Kimmelman, MD
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Alec Kimmelman works in the field of Radiation Oncology. He went to medical school at Icahn School of Medicine at Mount Sinai. Icahn School of Medicine at Mount Sinai is ranked 20/62 in Research/PrimaryCare. Alec Kimmelman is a published doctor and has 30 publications published. The lastest was: 'Mechanisms of selective autophagy in normal physiology and cancer.'
Publications
- Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.
- Inhibition of autophagy attenuates pancreatic cancer growth independent of TP53/TRP53 status.
- Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma.
- The Complex Landscape of Pancreatic Cancer Metabolism.
- Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.
- D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.
- Efficacy of BET Bromodomain Inhibition in Kras-Mutant Non-Small Cell Lung Cancer.
- Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance.
- SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism.
- Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
- PARI Overexpression Promotes Genomic Instability and Pancreatic Tumorigenesis.
- DNA Damage Enhancement from Gold Nanoparticles for Clinical MV Photon Beams.
- Inhibition of non-homologous end joining repair impairs pancreatic cancer growth and enhances radiation response.
- Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism.
- Targeting Autophagy Addiction in Cancer.
- The dynamic nature of autophagy in cancer.
- A critical role for autophagy in pancreatic cancer.
- Pten is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-?B-cytokine network.
- Pancreatic cancers require autophagy for tumor growth.
- Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.
- Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types.
- Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.
- Stromal biology of pancreatic cancer.
- Characterization of R-ras3/m-ras null mice reveals a potential role in trophic factor signaling.
- Genetics and biology of pancreatic ductal adenocarcinoma.
- R-Ras3/M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade.
- Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit.
- Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models.
- Mechanisms of selective autophagy in normal physiology and cancer.
Schools
Mount Sinai School Of Medicine Of New York University
Mt Sinai At Cabrini Med Center
Harvard Radiation Oncology Prg
Doctors Specialties
- Radiation Oncology
Accepted Insurances
Education
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Brigham and Women's Hospital -
Mount Sinai School of Medicine -
Icahn School of Medicine at Mount Sinai
Hospital
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Brigham and Women's Hospital -
Massachusetts General Hospital -
Dana-Farber Cancer Institute
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1891729877 |
| Last Name Of The Provider | KIMMELMAN |
| First Name Of The Provider | ALEC |
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