Physician
Endocrinology
Dr. Aldo A. Rossini, MD
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Aldo Rossini is an expert in the field of Endocrinology. He went to medical school at Saint Louis University School of Medicine. Saint Louis University School of Medicine is ranked 67 in research and 57 in primary care medicine He over the years received 1 awards: "Elected Member". Aldo A. Rossini is also a published doctor. He has 55 publication published. The most recent publication is: Blockade of the Programmed Death-1 (PD1) Pathway Undermines Potent Genetic Protection from Type 1 Diabetes.
Publications
- Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish.
- Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of m...
- NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection.
- A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells.
- TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.
- Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.
- Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.
- CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.
- Humanized mice for the study of type 1 diabetes and beta cell function.
- Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes.
- TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.
- Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice.
- A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
- Viral infection: a potent barrier to transplantation tolerance.
- Role of innate immunity in transplantation tolerance.
- Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.
- Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research.
- Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.
- Diabetes research in jeopardy: the extinction of clinical diabetes researchers.
- Passing the baton--to whom?
- Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice.
- TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat.
- A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3.
- ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose).
- Costimulatory blockade induces hyporesponsiveness in T cells that recognize alloantigen via indirect antigen presentation.
- Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.
- TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.
- A comprehensive review of interventions in the NOD mouse and implications for translation.
- Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
- TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats.
- Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.
- Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells.
- Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody.
- Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms.
- Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.
- Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.
- Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody.
- Deficiencies in gut NK cell number and function precede diabetes onset in BB rats.
- Autoimmune diabetes and the circle of tolerance.
- Rat models of type 1 diabetes: genetics, environment, and autoimmunity.
- Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
- Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microg...
- Ian4 is required for mitochondrial integrity and T cell survival.
- Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning.
- Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.
- Induction of tolerance for islet transplantation for type 1 diabetes.
- Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
- Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections.
- Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations.
- Blockade of CD40-mediated signaling is sufficient for inducing islet but not skin transplantation tolerance.
- NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.
- Viral abrogation of stem cell transplantation tolerance causes graft rejection and host death by different mechanisms.
- Treatment with anti-CD154 antibody and donor-specific transfusion prevents acute rejection of myoblast transplantation.
- Blockade of the Programmed Death-1 (PD1) Pathway Undermines Potent Genetic Protection from Type 1 Diabetes.
Schools
Saint Louis University School of Medicine
St Louis University Grp Hosps
Harvard Med School
Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- Elected Member
Education
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Brigham and Women's Hospital -
St Louis University School of Medicine -
Saint Louis University School of Medicine
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